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J Virol. Nov 1972; 10(5): 1075–1081.
PMCID: PMC356579
Visualization by Immune Electron Microscopy of a 27-nm Particle Associated with Acute Infectious Nonbacterial Gastroenteritis
Albert Z. Kapikian, Richard G. Wyatt, Raphael Dolin, Thomas S. Thornhill, Anthony R. Kalica, and Robert M. Chanock
1Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014
A 27-nm particle was observed by immune electron microscopy in an infectious stool filtrate derived from an outbreak in Norwalk, Ohio, of acute infectious nonbacterial gastroenteritis. Both experimentally and naturally infected individuals developed serological evidence of infection; this along with other evidence suggested that the particle was the etiological agent of Norwalk gastroenteritis.
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