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J Virol. 1972 November; 10(5): 1075–1081.
PMCID: PMC356579

Visualization by Immune Electron Microscopy of a 27-nm Particle Associated with Acute Infectious Nonbacterial Gastroenteritis


A 27-nm particle was observed by immune electron microscopy in an infectious stool filtrate derived from an outbreak in Norwalk, Ohio, of acute infectious nonbacterial gastroenteritis. Both experimentally and naturally infected individuals developed serological evidence of infection; this along with other evidence suggested that the particle was the etiological agent of Norwalk gastroenteritis.

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Selected References

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  • Adler JL, Zickl R. Winter vomiting disease. J Infect Dis. 1969 Jun;119(6):668–673. [PubMed]
  • Almeida JD, Rubenstein D, Stott EJ. New antigen-antibody system in Australia-antigen-positive hepatitis. Lancet. 1971 Dec 4;2(7736):1225–1227. [PubMed]
  • Almeida JD, Waterson AP. The morphology of virus-antibody interaction. Adv Virus Res. 1969;15:307–338. [PubMed]
  • Acute infectious nonbacterial gastroenteritis: etiology and pathogenesis. Ann Intern Med. 1972 Jun;76(6):993–1008. [PubMed]
  • Clarke SK, Cook GT, Egglestone SI, Hall TS, Miller DL, Reed SE, Rubenstein D, Smith AJ, Tyrrell DA. A virus from epidemic vomiting disease. Br Med J. 1972 Jul 8;3(5818):86–89. [PMC free article] [PubMed]
  • Dane DS, Cameron CH, Briggs M. Virus-like particles in serum of patients with Australia-antigen-associated hepatitis. Lancet. 1970 Apr 4;1(7649):695–698. [PubMed]
  • DINGLE JH, BADGER GF, FELLER AE, HODGES RG, JORDAN WS, Jr, RAMMELKAMP CH., Jr A study of illness in a group of Cleveland families. I. Plan of study and certain general observations. Am J Hyg. 1953 Jul;58(1):16–30. [PubMed]
  • BADGER GF, CURTISS C, DINGLE JH, HODGES RG, JORDAN WS, Jr, MCCORKLE LP. A study of illness in a group of Cleveland families. XIII. Clinical description of acute nonbacterial gastroenteritis. Am J Hyg. 1956 Nov;64(3):368–375. [PubMed]
  • Dolin R, Blacklow NR, DuPont H, Buscho RF, Wyatt RG, Kasel JA, Hornick R, Chanock RM. Biological properties of Norwalk agent of acute infectious nonbacterial gastroenteritis. Proc Soc Exp Biol Med. 1972 Jun;140(2):578–583. [PubMed]
  • Dolin R, Blacklow NR, DuPont H, Formal S, Buscho RF, Kasel JA, Chames RP, Hornick R, Chanock RM. Transmission of acute infectious nonbacterial gastroenteritis to volunteers by oral administration of stool filtrates. J Infect Dis. 1971 Mar;123(3):307–312. [PubMed]
  • FUKUMI H, NAKAYA R, HATTA S, NORIKI H, YUNOKI H, AKAGI K, SAITO T, UCHIYAMA K, KOBARI K, NAKANISHI R. An indication as to identity between the infectious diarrhea in Japan and the afebrile infectious nonbacterial gastroenteritis by human volunteer experiments. Jpn J Med Sci Biol. 1957 Feb;10(1):1–17. [PubMed]
  • GORDON I. The nonamebic nonbacillary diarrheal disorders. Am J Trop Med Hyg. 1955 Jul;4(4):739–755. [PubMed]
  • GORDON I, MENEELY JK, Jr, CURRIE GD, CHICOINE A. Clinical laboratory studies in experimentally-induced epidemic nonbacterial gastroenteritis. J Lab Clin Med. 1953 Jan;41(1):133–141. [PubMed]
  • JORDAN WS, Jr, GORDON I, DORRANCE WR. A study of illness in a group of Cleveland families. VII. Transmission of acute non-bacterial gastroenteritis to volunteers: evidence for two different etiologic agents. J Exp Med. 1953 Nov;98(5):461–475. [PMC free article] [PubMed]
  • Kapikian AZ, Almeida JD, Stott EJ. Immune electron microscopy of rhinoviruses. J Virol. 1972 Jul;10(1):142–146. [PMC free article] [PubMed]
  • TATENO I, SUZUKI S, KAGAWA S, NAITO H, GOTO T. On an ECHO-like agent constantly recoverable from volunteers given Niigata strain of acute epidemic gastroenteritis. Jpn J Exp Med. 1956 Aug;26(3-4):125–138. [PubMed]

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