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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
Mol Cell. Author manuscript; available in PMC 2013 June 14.
Published in final edited form as:
Mol Cell. 2012 December 14; 48(5): 760–770.
Published online 2012 November 8. doi: 10.1016/j.molcel.2012.10.002

Figure 4

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Characteristics of non-canonical sites

(a) Variations in canonical (top) and non-canonical (bottom) motifs in miR-155-dependent sites. Number in parentheses indicates the number of miR-155-dependent AGO binding sites containing the motif. (b) Cross-linking induced deletions around canonical seed matches and non-canonical seed-like motifs. (c) Enrichment for inexact 6mer and 7mer motifs in non-canonical miR-155-dependent binding sites relative to all binding sites. (d) Enrichment of 3′ complementarity in non-canonical miR-155 binding sites. Enrichment of motifs complementary to miR-155 was examined in a 16-nucleotide regions found 3-18nt 5′ of inexact seed matches in non-canonical sites relative to equally sized regions in Argonaute binding sites lacking miR-155 seed matches. Enrichments were calculated using Fisher’s Exact Test. (e) AU content in a 100nt window centered at seed matches or non-canonical seed-like motifs.

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