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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptNIH Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
 
JAMA. Author manuscript; available in PMC Jan 31, 2013.
Published in final edited form as:
PMCID: PMC3560393
NIHMSID: NIHMS434026
Effects of a Brief Intervention for Reducing Violence and Alcohol Misuse Among Adolescents: A Randomized Trial
Rebecca M. Cunningham, MD,1,6 Stephen T. Chermack, Ph.D.,1,2 Jean T. Shope, Ph.D,3,4 C. Raymond Bingham, Ph.D,3,4 Marc A. Zimmerman, Ph.D.,3 Frederic C. Blow,1,2 and Maureen A. Walton, MPH, Ph.D
1University of Michigan, Department of Emergency Medicine, Ann Arbor, Michigan, USA University of Michigan, Department of Psychiatry, Ann Arbor, Michigan, USA
2Department of Veterans Affairs, Health Services Research and Development, Ann Arbor, Michigan, USA
3University of Michigan, School of Public Health, Ann Arbor, Michigan, USA
4University of Michigan Transportation Research Institute, Ann Arbor, Michigan
6Hurley Medical Center, Flint, Michigan, USA
Context
The Emergency Department (ED) visit presents an opportunity to deliver brief interventions (BIs) to reduce violence and alcohol misuse among urban adolescents at risk for future injury.
Objectives
To determine the efficacy of BIs addressing violence and alcohol among adolescents presenting to an urban ED.
Design, Setting, and Participants
Patients (ages 14–18; 12 pm–11 pm; 7 days/week) at a Level 1 ED in Flint, MI, completed a computerized survey. Adolescents reporting past year alcohol use and aggression were enrolled in a randomized trial (SafERteens) which included: a computerized baseline assessment, randomization to a control group, or a 35-minute brief intervention delivered by a computer or therapist in the ED, and follow-up assessments at 3 and 6 months.
Intervention
Combining motivational interviewing with skills training, the BI for violence and alcohol included: review of goals, tailored feedback, decisional balance exercise, role plays, and referrals.
Main Outcome Measures
Self-report measures included peer aggression and violence, violence consequences, alcohol use, binge drinking, alcohol consequences.
Results
3338 adolescents were screened (n=446, 12% refused): 1452 (43.5%) male; 1866 (55.9%) African-American. Of those, 829 (24.8%) screened positive for both alcohol and violence; 726 were randomized. As compared to the control, participants in the therapist intervention showed self-reported reductions in the occurrence of peer aggression (−34.3% therapist, −16.4% control; RR=0.74, CI=0.61–0.90), experience of peer violence (10.4% therapist, +4.7% control; RR=0.70, CI=0.52–0.95), and violence consequences (30.4% therapist, −13.0% control; RR=0.76, CI=0.64–0.90) at three months. At 6 months, participants in the therapist intervention showed self-reported reductions in peer aggression (−37.7% therapist, −28.4% control; RR=0.85, CI=0.68–1.06) and alcohol consequences (−32.2% therapist, −17.5% control; RR=0.56, CI=0.34–0.91) as compared to controls. At 6 months, participants in the computer intervention also showed self-reported reductions in alcohol consequences (−29.1% computer, −17.5% control; RR=0.62, CI=0.39–0.98).
Conclusions
Among adolescents identified in the ED with self-reported alcohol use and aggression, a brief intervention resulted in a decrease in the prevalence of self-reported aggression and alcohol consequences.
Trial Registration
ClinicalTrials.gov Identifier NCT00251212.
In the U.S. in 2006, there were 19,525,000 visits by patients ages 15–24.1 The ED is an important contact point for medical care for adolescents, especially underinsured and uninsured patients.2, 3 Prevention programs in the ED may reach adolescents who do not attend school regularly, or who lack a primary care physician, or who view themselves as too old to be seen by pediatricians and have not established adult medical care. Adolescents seeking care in the ED are an important population for injury prevention based on increased risk for problems related to alcohol and violence.4, 5 Despite a recent increase in ED-based interventions for youth violence69 or alcohol use,1013 few ED studies have examined brief interventions (BI)that address reductions in violence, or the combination of these co-occurring risk behaviors (e.g., violence and alcohol).14 These approaches could have substantial public health impact, especially if designed to be easily incorporated into ED practice. Computerized brief interventions are mostly untested in the ED and offer a practical solution to barriers in this setting.
This manuscript examines 3 and 6 month outcomes from a randomized control trial (RCT) (SafERteens Study) of a therapist brief intervention (assisted by a computer) or a computer brief intervention as compared to a control condition among adolescents (ages 14–18) presenting to an urban ED who screened positive for violence and alcohol use. Hypotheses were that the therapist and computer interventions would be more effective than the control on reducing violence and alcohol misuse at 3 and 6 months.
Study Setting
The SafERteens RCT took place at Hurley Medical Center in Flint, Michigan, a Level I Trauma Center. Study procedures were approved by the University of Michigan and HMC Institutional Review Boards (IRB), for Human Subjects; a NIH Certificate of Confidentiality was obtained.
Participants
ED patients (ages 14, 15, 16, 17, and 18) presenting for medical illness or injury were eligible for screening. Exclusions were: acute sexual assault or suicidal ideation, altered mental status precluding consent, or medically unstable (i.e., abnormal vital signs).
Study Protocol
Recruitment occurred from 12 pm–11 pm, seven days per week (9/06–9/09), excluding major holidays. Adolescent patients identified from electronic logs were approached by research assistants (RAs) in waiting rooms or treatment spaces. Following written consent (and assent and parent/guardian consent if < 18), participants self-administered a 15-minute computerized survey with audio, and received a $1.00 gift.
Study Eligibility
After completing the survey, participants reporting both past-year aggression (see Measures; peer, dating, weapon carriage/use) and alcohol consumption (“In the past 12 months, have you had a drink of beer, wine or liquor more than two to three times? Do not count just a sip or taste of someone else’s drink.”)15 were eligible for the RCT. Note that participants reporting only one behavior (aggression or alcohol) were not eligible.
RCT Procedures
Following written consent (and assent and parent/guardian consent if < 18), for the RCT, participants self-administered a computerized baseline assessment ($20 remuneration). As required by the IRB, participants were told they would be randomly assigned to one of three groups: computer session, counselor session, or brochure. Participants were blind to condition assignment until after the baseline assessment. After the baseline, participants were randomized and received the therapist brief intervention, computer brief intervention, or control brochure during the ED visit. Randomization was stratified by sex (male/female) and age (14–15/16–18) assigned based on computer generated algorithm and using numbered sealed envelopes. Randomization occurred blocks of 21 (7 per group).
Follow up interviews
Participants self-administered computerized assessments 3 and 6 months after the ED visit at a convenient location (e.g., home, ED, restaurant); remuneration was $25 and $30 respectively. Follow-up staff were blind to baseline condition assignment.
Measures
Previously validated measures were used; piloting (n=23) was conducted to ensure youth could understand and self-administer the assessments and interventions.1618 The time frame for questions was the past year at screening/baseline and past 3 months at follow-ups.
Demographics
Questions included: age, gender, race, ethnicity, and receipt of public assistance.15
Alcohol Use
Frequency (how often), quantity (on a typical occasion), and binge drinking (5 or more) were assessed with the Alcohol Use Disorders Identification Test-Consumption (AUDIT-C).19, 20 As recommended for adolescents,21 binge drinking quantity was five drinks instead of six. Piloting revealed that question 1 response options were misunderstood by urban teens and were replaced with the response options for question 3. An Alcohol Consumption summary variable was computed (α = 0.81); among adolescents, the cut-off is ≥3 for an alcohol use disorder.21
Alcohol Consequences
The 17-item substance abuse scale from the Problem Oriented Screening Instrument for Teenagers (POSIT)22 measured alcohol consequences (e.g., missed school, trouble getting along with friends because of drinking). An Alcohol Consequences summary variable was created (α = 0.83). Among adolescents, the cut-off is 2 for an alcohol use disorder.23
Aggression
Ten items 24, 25 assessed frequency of aggression toward peers and included moderate (e.g., pushed or shoved) and severe (e.g., hit or punched, used a knife/gun) (α = 0.86) aggression. Peer Aggression was computed by summing the mid-point of the responses.26 Knife/razor and gun carriage frequency was assessed using two items. Two items assessed frequency of moderate and severe dating aggression.5, 27
Experience of peer violence (being a victim of moderate or severe peer violence) was assessed by collapsing the moderate and severe CTS items into two questions. The score was computed by summing the mid-point of the items (α = 0.77).
Violence Consequences
Using a 7-item scale developed for this study, participants identified consequences of fighting (i.e., trouble at school, hurt someone, constant desire to fight, family or friends suggested you stop, arguments with family or friends, trouble getting along with friends, can’t control fighting). A Violence Consequences summary variable was created (α = 0.78).
Visit type
Current ED visit reason (i.e., chief complaint) was abstracted from the medical chart, medical illness (e.g., abdominal pain, asthma), or injury (ICD–9–intentional (E950–E969) or unintentional (E800–E869, E880–E929). Chart reviews were audited regularly to maintain reliability using established criteria.28
SafERteens Brief Interventions
Participants received their assigned condition prior to ED discharge in treatment spaces; interventions could be stopped and re-stared as needed to avoid interference with medical care. Research staff ensured that sessions were completed privately. Participants in all groups received a brochure with community resources. The SafERteens brief interventions were based on principles of motivational interviewing,29, 30 but also involved normative resetting and alcohol refusal and conflict resolution skills practice (see below and31). The therapist and computer interventions were designed to have similar sections, but with different modes of presentation. They were developed to be culturally relevant for urban youth, who at this study site were ~ 50% African-American. The sections included: goals, personalized feedback for alcohol, violence, and weapon carriage, decisional balance exercise for the potential benefit of staying away from drinking and fighting, five tailored role-plays (e.g., anger management, conflict resolution, alcohol refusals, not drinking and driving, etc.), and referral. Although both interventions reviewed these content areas in a way that was consistent with tenets of motivational interviewing (i.e., non-judgmental), the mode of delivery resulted in important differences. For example, it was not possible for the computer to provide complex interpersonal responses that a skilled therapist could deliver.
The therapist intervention was also facilitated by a tablet laptop computer which displayed tailored feedback for participants, and screens to prompt content for the therapists. Research social workers were initially trained on motivational interviewing techniques and the specific SafERteens intervention. Based on harm reduction principles, which are well suited for adolescents,32, 33 motivational interviewing emphasizes developing a discrepancy between current behavior and future goals, increasing problem recognition, motivation, and self-efficacy. To ensure fidelity, sessions were audio taped and 20% were coded based for adherence and competence; therapists received individual and group supervision and periodic re-trainings to throughout the study.
The computer intervention developed for this study was a stand-alone interactive animated program,31 with touch screens and audio via headphones to ensure privacy. The buddy guided participants through the intervention components via audio feedback for the choices made focusing on tipping the decisional balance away from risk behaviors. The entire computer program was an interaction, not passively viewed. For example, during the role-play scenarios, participants had to interact with peers and make behavioral choices about drinking and fighting.
Data analysis
Data were analyzed using SAS Version 9 (SAS Institute, Inc., Cary, NC). Descriptive statistics were computed for the total sample and by assigned condition. Because of baseline differences by condition in rates of participant school drop-out, this variable was initially included in analyses to control for group differences. Models are presented without this covariate, however, because it was unrelated to outcomes when it was included in initial analyses. For descriptive purposes, rates of occurrence of risk behaviors are presented as percents along with percent change at 3 and 6 months. At baseline, a single imputation procedure was used to complete missing alcohol misuse scores for 5 participants. Statistical significance was set at p<.05, 1-tailed, and expressed as a 95% confidence interval.
Data were analyzed using generalized estimating equations (GEE), due to the correlated structure of data from repeated measures at baseline, 3, and 6 month follow-up.34 GEE analyses allows for observed variable distributions (e.g., binary/logit, continuous/negative binomial). An intent to treat approach was used in which all randomized participants (n=726) were included because GEE analyses include all cases, even drop-outs, by using available pairs to estimate working correlation parameters for the entire sample. The study was powered to detect differences between intervention groups and the control, not between treatment conditions (e.g., therapist brief intervention and computer brief intervention); thus, analyses compared each intervention condition separately to the control condition. Based on 15% reduction in occurrence of a risk behavior and p<.05, n=107 per group is needed for power = 0.8.; thus, the analyses were adequately powered.
Because the intervention focused on decreasing the occurrence as well as the frequency of the risk behaviors, GEE analyses were conducted examining group differences over time in the occurrence (binary variables) and frequency (continuous variables) of primary outcomes(i.e., peer aggression, violence consequences, alcohol misuse (AUDIT-C score), binge drinking, and alcohol consequences] and secondary outcomes (i.e., experience of peer violence). GEE analyses produces a model group by time interaction effect, as well as specific group by time interaction effects for the therapist and computer conditions as compared to the control. For conservative purposes, only models with significant overall group by time interaction effects were examined further to determine intervention effectiveness (i.e., therapist group by time interaction, computer group by time interaction). A significant therapist group by time interaction effect indicates that the intervention condition significantly differs from the control in a specific outcome; thus, this analysis approach considers baseline values and the relative change over time in outcomes based on group assignment. Regarding effect sizes, for outcomes using binary variables percent change was computed. For continuous variables, Cohen’s effect sizes35 were calculated which indicate the strength of the relationship between the intervention and the observed outcome and allows for comparisons across studies; the prevention literature suggests that effect sizes =0.10 are clinically meaningful.36
Flow Chart
Among 4296 potentially eligible patients presenting during recruitment, 88.1% (n=3784) were approached (see Figure 1 for details). For screening, no race differences were observed in refusals; males were more likely to refuse than females (n=224, 13.0%; n=222, 10.7% respectively; X2(1)=4.72, p<0.05). For baseline, African-Americans were less likely to refuse than Other races (n=41, 9.2%; n=60, 15.8%, X2(1)=8.4, p<.01); males were more likely to refuse than females (n=56, 15.1%;n=45, 9.9%, respectively; X2(1)=5.1, p<.05). The follow-up rate exceeded 85%.
Figure 1
Figure 1
SafERteens Flowchart (September 2006 to September 2009).
Sample Description
Table 1 characterizes of the sample by assigned condition. Participants assigned to the computer intervention were more likely to have dropped out of school as compared to the therapist intervention or control. No other significant differences were observed between groups.
Table 1
Table 1
Baseline Background, Violence, and Substance use Characteristics.
Occurrence of Violence/Alcohol Use (Binary)
GEE models were computed for occurrence of violence (severe peer aggression, any experience of peer violence, any violence consequences) and alcohol (alcohol misuse ≥ 3, any binge drinking, alcohol consequences ≥2) at 3 and 6 months (see Table 2 for descriptive data and Tables 3 and and44 for GEE results). Participants in the therapist intervention were less likely to report any severe peer aggression at 3 months (model group by time interaction X2(2)=11.79, p=0.0027) and 6 months (model group by time interaction X2(2)=3.02, p=0.2208), experience of peer violence at 3 months (model group by time interaction X2(2)=6.96, p=0.0308), and violence consequences at 3 months (model group by time interaction X2(2)=14.50, p=0.0007) than controls. Models were not significant for alcohol misuse or binge drinking at 3 and 6 months or for alcohol consequences at 3 months. At 6 months, the alcohol consequences model was significant (model group by time interaction X2(2)=5.55, p=0.0624); participants in the therapist and computer conditions were less likely to report consequences than controls.
Table 2
Table 2
Self-report of alcohol and violence over time.
Table 3
Table 3
GEE analyses examining occurrence of violence and alcohol risk variables baseline to 3 months based on intervention groups.
Table 4
Table 4
GEE analyses examining occurrence of violence and alcohol risk variables baseline to 6 months based on intervention groups.
Frequency of Violence/Alcohol Use (Continuous)
GEE models were computed for frequency of violence (peer aggression, experience of peer violence, violence consequences) and alcohol (alcohol misuse, binge drinking, alcohol consequences) at 3 months and 6 months (data not presented). The models were not significant for the frequency of peer aggression or experience of peer violence at 3 and 6 months or for the frequency of violence consequences at 6 months. The model for the number of violence consequence at 3 months was significant (model group by time interaction X2(2)=8.56, p=0.0138). Participants in the therapist intervention decreased the number of violence consequences compared to controls at 3 months (therapist group by time interaction, p=0.0051; effect size 0.27; odds ratio = 0.77; confidence interval 0.65–0.93). None of the models were significant for the alcohol frequency variables.
Although replication is required, data presented provides novel findings demonstrating that a brief intervention for violence and alcohol among adolescents presenting to an urban ED shows promise, reducing peer violence and alcohol consequences over a 6 month period. Given that a leading cause of mortality and morbidity in this age group is violence, the reduction in the occurrence of severe violence following a single session brief intervention is clinically meaningful. Specifically, only 8 at-risk adolescents (with past year alcohol use and aggression) would need to receive the therapist intervention in order to prevent severe peer aggression in one adolescent. In addition, participants in the therapist intervention reported a reduction in the occurrence of experience of peer violence and frequency of violence consequences at 3 months. Clinically, a trained ED based therapist would need to deliver this 30 minute intervention to 10 at-risk adolescents to prevent one adolescent from being victimized by a peer. In a similar manner, the number of adolescents needed to treat with the therapist intervention is 6 in order to reduce violence consequences in one adolescent.
This study focused on at-risk youth seeking general ED care for a single session intervention delivered completely during the teachable moment of the acute care visit. Prior hospital and ED interventions for youth violence have focused on patients with intentional injury and have typically used multi-session case management or mentoring approaches.6, 9, 37 Additional studies with larger samples of adolescents who are seeking care following an intentional injury (i.e., assault, gun-shot) are needed to determine the effectiveness of this intervention among youth with more severe violence profiles. Few ED studies have examined alcohol brief interventions among adolescents. Adolescents in the therapist intervention and the computer intervention were less likely to report alcohol related consequences (e.g., missed school, trouble with friends) than the control condition over the 6 month follow-up. Clinically, to prevent alcohol consequences in one adolescent, 17 adolescents would need to receive the therapist intervention; alternatively, 13 adolescents would need to receive the computer intervention to prevent alcohol consequences in one adolescent. These mixed findings for reductions in alcohol consequences but not consumption is consistent with prior adolescent studies of a therapist brief intervention6 and computer brief intervention38 in the ED.11
Data from this study did not support the effectiveness of the stand alone computerized intervention for reducing violence. It is important to recognize however, that the computer played a role in the therapist condition. As recently recommended,26 assessments were computerized and the adolescent and therapist reviewed tailored feedback presented on the computer. The computer screens standardized the delivery of the intervention by the therapist; such approaches are appealing as a mechanism to prompt content for busy ED staff.
Limitations
A limitation of this study is that it is not possible for participants to be blinded to intervention condition given current IRB requirements. This concern is somewhat mitigated by blinding of follow-up staff to intervention condition assignment as well as by the self-administered nature of assessments. Findings may not generalize to patient groups not included in this single site study, such as adolescents presenting during overnight shifts, with acute suicidal ideation/attempt, or sexual assault. Although the sample reflected the ED study site composition, replication with other sites and samples (e.g., Hispanics) are needed. The self-report data is a potential limitation; however, recent reviews support the reliability and validity of self-report of risk behaviors when privacy/confidentiality is assured and when using self-administered computerized assessments.39 Although the follow-up rates exceeded 85% and analyses included all participants regardless of drop-out, attrition is a limitation of this study. Findings are limited by the six-month follow-up. Future studies are needed that examine long-term follow-up, moderators of outcome such as age, and the temporal relationship between acute alcohol consumption and violence using calendar-based assessments.40
Conclusions
Although replication is required, findings support the efficacy of a therapist brief intervention (with computerized feedback and structure) in decreasing the occurrence of adolescent peer violence and alcohol consequences in the 6 months following an ED visit. In addition, both the therapist and the computer brief intervention was effective at reducing of alcohol consequences over 6 months. Computerized approaches could assist in translating research findings into routine clinical practice by standardizing intervention delivery, and have widely applicability across other content areas and settings.
Acknowledgments
This project was supported by a grant (#014889) from the National Institute on Alcohol Abuse and Alcoholism (NIAAA). We would like to thank project staff for their work on the project; also, we would like to thank Pat Bergeron (not paid by the project) for administrative assistance and Linping Duan, M.S. for statistical support (paid analyst by the project). Finally, special thanks are owed to the patients and medical staff at Hurley Medical Center for their support of this project.
Role of Sponsor: NIAAA had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review or approval of the manuscript.
Footnotes
Financial Disclosures:
There are no conflicts of interest, including specific financial interests and relationships and affiliations relevant to the subject of this manuscript to report.
Author Contribution: Drs. Walton and Cunningham had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Drs. Walton, Cunningham, Blow, and Chermack were responsible for the acquisition of data. Drs. Walton, Cunningham, Chermack, Shope, Bingham, Zimmerman, and Blow conceptualized the study and are investigators on the grant funding this work. Drs. Walton, Cunningham and Chermack were responsible for the statistical analysis plan and wrote the initial draft of the manuscript. Drs. Shope, Bingham, Zimmerman, and Blow provided critical feedback and revision of the manuscript. All authors contributed to and have approved the final manuscript.
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