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J Radiol Case Rep. 2012 July; 6(7): 17–22.
Published online 2012 July 1. doi:  10.3941/jrcr.v6i7.1015
PMCID: PMC3558046

Esophageal Lipoma: A Rare Tumor


Esophageal lipomas are rare tumors, making up 0.4% of all digestive tract benign neoplasms. Most of these lesions are clinically silent as a result of their small size, however, the majority of lesions over 4 cm have been reported to cause dysphagia, regurgitation and/or epigastralgia. We report a case of a 53 year-old African American female who presented with dysphagia. Computed tomography of the chest and esophagram confirmed esophageal lipoma as the cause of the patient’s symptoms. Accurately diagnosing an esophageal lipoma is crucial in order to rule out potential malignant lesions, relieve patient symptoms and plan the appropriate treatment.

Keywords: Esophageal Lipoma, Esophagus


A 53 year-old African American female with Human T-lymphotropic virus Type 1 (Adult T-Cell Leukemia/Lymphoma) presented for an esophagram with a diagnosis of dysphagia. Findings were significant for an upper esophageal submucosal lesion with luminal narrowing (Figure 1). There was no evidence of a “squeeze sign”. The etiology of the filling defect was unclear at this time. Intermittent mild tertiary spasm also likely contributed to the dysphagia.

Figure 1
53-year-old African American female with dysphagia who presented for a double contrast esophagram was found to have an esophageal lipoma. Upper left image: Left posterior oblique image demonstrates an esophageal submucosal lesion extending from T1–T3, ...

Subsequently, the patient had a CT (computed tomography) of the chest. The study was originally scheduled to evaluate a left lower lung pulmonary nodule prior to the findings discovered on the esophagram, which also warranted additional evaluation with a CT of the chest. The examination showed a hypoattenuating, 4.5 × 1.4 × 1.2 cm submucosal mass in the posterior wall of the upper thoracic esophagus, with Hounsfield units ranging between -90 and -110 (Figure 2). The mass, with imaging characteristics consistent with a lipoma, corresponded to the lesion seen on the prior esophagram. The esophageal mass remained unchanged on three subsequent thoracic CT scans over a course of three years that were performed for further follow-up of the pulmonary nodule. The patient has declined endoscopy and surgical excision of the lesion.

Figure 2
53 year old African American female presents for evaluation of a left lower lobe pulmonary nodule was found to have an esophageal lipoma. Upper left image: Sagittal non-enhanced CT of the chest demonstrates a submucosal, hypoattenuating lesion with fat ...


Benign esophageal tumors are rare, representing less than 1% of all esophageal neoplasms. In decreasing order of occurrence, lesions that have been found in the esophagus include leiomyomas, fibrovascular polyps, squamous papillomas, granular cell tumors, lipomas, neurofibromas, and inflammatory fibroid polyps. Additional especially rare benign esophageal tumors include hemangiomas and hamartomas [1, 2]. These masses are usually discovered incidentally, as many of them are small and asymptomatic.

Lipomas of the alimentary tract are uncommon, making up 4.1% of all benign tumors. More specifically, lipomas of the esophagus are extremely rare, accounting for only 0.4% of all digestive tract benign neoplasms [3, 4]. They generally become symptomatic only when they are large enough to cause dysphagia, at which time they merit surgical excision [5].

The exact etiology of lipomas is uncertain, however, one theory suggests an association between previous trauma and subsequent lipoma formation [6]. Lipomas are found in all areas of the GI (Gastrointestinal) tract, most commonly in the colon, followed by the small intestine. Less common locations include the stomach and esophagus. Lipomas throughout the GI tract have an incidence of 1 in 600 necropsies [4]. Fewer than 20 surgical cases of esophageal lipomas have been reported in the literature [5].

The likelihood of a lipoma causing symptoms is related to its size. According to Hurwitz et al., no GI tract lipoma under 1 cm caused symptoms, compared with (75%) over 4 cm [7]. 85% of Lipomas in the esophagus are clinically silent, therefore the majority of them are found incidentally on radiographic imaging [8]. If symptomatic, patients can experience dysphagia, regurgitation, recurrent melena and/or epigastralgia [7, 9]. The most frequent complaint is dysphagia.

In general, gastrointestinal lipomas are more common in females, however, esophageal lipomas are more common in men than women with a reported ratio of 27:13 [8, 10]. Esophageal lipomas have been reported in patients between the ages of 4 and 80 years old, with a mean age of 50 [4, 5]. Usually esophageal lipomas originate in the cervical and upper thoracic esophagus [5].

Establishing a correct diagnosis of an esophageal lipoma demands a careful history, thorough radiographic examination and/or inspection with upper GI endoscopy. Radiographically, lipomas present as intraluminal filling defects. Useful signs to differentiate lipomas from other benign or malignant lesions include a smooth surface and “squeeze” sign manifested by changes in contour and configuration as a result of peristalsis [7]. Presentation of a lipoma on upper GI endoscopy is a lesion of yellow color, pliability and a smooth surface. Malignant lesions tend to be friable and irregular, with an ulcerated surface [5].

Leiomyomas, the most common benign esophageal tumor, has subtle differences from that of a lipoma. Radiologically they appear as a well-defined mass with muscle density and occasionally contain nodular calcifications. This translates to a hypoattenuating lesion on CT, a hypoechoic lesion with fine echoes, in the setting of calcifications, on endoscopic ultrasound and a tan mass on upper GI endoscopy [11, 12]. Of particular importance, a liposarcoma, another very rare lesion, should not be confused with a lipoma. There are multiple histologic subtypes of liposarcomas that can range from yellow to a gray-tan color. They appear heterogeneous with areas of increased echogenicity, corresponding to areas of fat, on endoscopic ultrasound [13, 14, 15]. On CT, a liposarcoma is heterogeneous, contains septa and tissue other than fat, as compared to a lipoma, which presents as a homogenous lesion with fat density [4, 5]. Therefore, a homogenous lesion containing fat density on CT is diagnostic of a lipoma [4, 16, 17]. Esophageal lipomas appear as smooth and well-defined hyperechoic lesions on endoscopic ultrasound [11, 17]. On MRI, lipomas can be identified by following fat signal as T1-weighted hyperintensity that becomes hypointense on fat-suppressed images [18]. On the contrary, liposarcomas appear heterogeneous with high signal intensity on T1 and T2 weighted images and leiomyomas are iso intense on T2 -weighted images [12, 19]. Historically, these three lesion types have been evaluated by esophagram, but because all of these lesions present as discrete masses causing filling defects, further evaluation is necessary for definitive diagnosis.

Most esophageal lipomas are small, solitary, are asymptomatic and do not require treatment. Large symptomatic lipomas, however, require surgical resection. The different surgical options include a mini-thoractomy, cervical thoracotomy, endoscopy and videothoracoscopy [5]. In conclusion, careful diagnosis of an esophageal lipoma is necessary to exclude other potential malignant lesions and relieve patient symptomatology.


Lipomas of the esophagus are rare and are usually discovered incidentally unless they are large enough to cause symptoms, most commonly dysphagia. Diagnosis of an esophageal lipoma can be safely accomplished using computed tomography, presenting as a homogeneous lesion with fat density.

Table 1
Summary table for esophageal lipoma
Table 2
Differential table for esophageal lipoma


Computed Tomography
Magnetic Resonance Imaging


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