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Dialogues Clin Neurosci. 2012 December; 14(4): 381–399.
PMCID: PMC3553569

Language: English | Spanish | French

The effects of extremely low-frequency magnetic fields on melatonin and cortisol, two marker rhythms of the circadian system

Los efectos de los campos magnéticos de frecuencias extremadamente bajas en la melatonina y el cortisol, dos ritmos marcadores del slstema circadiano

Les effets des champs magnétiques de très faible fréquence sur la mélatonine et le cortisol, deux rythmes-marqueurs du système circadien

Yvan Touitou, PhD*
Yvan Touitou, Chronobiology Unit, Foundation A. de Rothschild, Paris, France;


In the past 30 years the concern that daily exposure to extremely low-frequency magnetic fields (ELF-EMF) (1 to 300 Hz) might be harmful to human health (cancer, neurobehavioral disturbances, etc) has been the object of debate, and has become a public health concern. This has resulted in the classification of ELF-EMF into category 2B, ie, agents that are “possibly carcinogenic to humans” by the International Agency for Research on Cancer. Since melatonin, a neurohormone secreted by the pineal gland, has been shown to possess oncostatic properties, a “melatonin hypothesis” has been raised, stating that exposure to EMF might decrease melatonin production and therefore might promote the development of breast cancer in humans. Data from the literature reviewed here are contradictory. In addition, we have demonstrated a lack of effect of ELF-EMF on melatonin secretion in humans exposed to EMF (up to 20 years' exposure) which rebuts the melatonin hypothesis. Currently, the debate concerns the effects of ELF-EMF on the risk of childhood leukemia in children chronically exposed to more than 0.4 μT. Further research is thus needed to obtain more definite answers regarding the potential deleterious effects of ELF-EMF.

Keywords: magnetic field, cortisol, melatonin, circadian rhythm, environment, cancer, neurobehavioral disturbances, marker rhythm, rhythm desynchronization, chronodisruption


En los últimos 30 años la preocupación acerca de que la exposición diaria a campos magnéticos de frecuencias extremadamente bajas (ELF-EMF) (1 a 300 Hz) podría ser dañina para la salud humana (cáncer, trastornos neuroconductuales, etc.) ha sido objeto de debate y ha llegado a constituir un tema de preocupación para la salud pública. Esto ha llevado a que la Agencia Internacional para la Investigación del Cáncer haya clasificado a los ELF-EMF en la categoría 2B, es decir, agentes que son “posiblemente carcinogénicos para los humanos”. Ya que se ha demostrado que la melatonina, neurohormona secretada por la glándula pineal, posee propiedades oncostáticas, ha surgido la “hipótesis melatoninérgica”, la cual plantea que la exposición a EMF podría disminuir la producción de melatonina y así promover el desarrollo de cáncer de mama en humanos. Los datos de la literatura revisados aquí son contradictorios. Además, nosotros hemos demostrado una falta de efecto de ELF-EMF en la secreción de melatonina en humanos expuestos a EMF (por exposiciones de hasta 20 años) lo que refuta la hipótesis melatoninérgica. Actualmente el debate se centra en los efectos de ELF-EMF sobre el riesgo de leucemia infantil en niños crónicamente expuestos a más de 0,4 μT. Se requiere de futuras investigaciones para obtener respuestas más definitivas relacionadas con los efectos potencialmente deletéreos de ELF-EMF.


L'exposition quotidienne aux champs électromagnétiques de basse fréquence (ELF-EMF) (1 à 300 Hz) a été l'objet dans les 30 dernières années de débats et de l'inquiétude du public sur la nocivité des ELF-EMF sur la santé (cancer, perturbations neurocomportementales) entraînant leur classification dans le groupe 2B du CIRC, groupe des agents «possiblement carcinogènes pour l'homme». Comme la mélatonine, une neurohormone sécrétée par la glande pinéale, possède des propriétés oncostatiques, «l'hypothèse de la mélatonine» a suggéré que les ELF-EMF diminuaient la synthèse de l'hormone et entraînaient ainsi le développement de cancers chez l'homme. Les articles que nous avons recensés dans la littérature sont très contradictoires. Nous avons pour notre part démontré l'absence d'effets des ELF-EMF sur la mélatonine chez des travailleurs exposés (jusqu'à 20 ans d'exposition) aux champs élecromagnétiques. Le débat porte actuellement sur le risque de leucémie chez l'enfant exposé de façon chronique à un champ supérieur à 0,4 μT. D'autres recherches sont nécessaires pour apporter une réponse définitive aux effets potentiellement dangereux des ELF-EMF sur l'homme.


We are continuously exposed in our environment to electromagnetic fields (EMF) which are either of natural origin (geomagnetic field, intense solar activity, thunderstorms) or manmade (factories, transmission lines, electric appliances at work and home), magnetic resonance imaging, medical treatment, etc. Electric and magnetic fields which exist wherever electricity is generated, transmitted, or distributed correspond to three frequency ranges: the extremely low frequency (ELF) range includes the frequencies (50 Hz in Europe, 60 Hz in North America) of the electric power supply and of electric and magnetic fields (EMF) generated by electricity power lines and electric/electronic appliances; intermediate frequency (IF, 300 Hz to <10 MHz) is used in computer monitors, industrial processes, and security systems; and finally, radiofrequency range (RF, 10 MHz to 300 GHz) includes radars, and radio and television broadcasts and telecommunications.

Biological effects of ELF-EMF and their consequences on human health have become the subject of important and recurrent public debate. The growth of electric power use in industrialized countries and the parallel increase of environmental exposure to ELF-EMF resulted in a widespread concern that ELF-EMF may have harmful effects in humans, a concern stimulated in the past decades by a number of epidemiologic studies reporting deleterious effects of ELF-EMF on human health. Wertheimer and Leeper1,2 published the first report, conducted in the Denver area, on the association between childhood cancer and exposure to ELF-EMF, with the conclusion of a higher risk of childhood leukemia at higher residential ELF-EMF exposure. Savitz et al3 gave support to this assertion with the publication of similar results in the same area (Denver). From then, several epidemiologic papers have reported a possible link, without any experimental evidence, however, between exposure of humans to ELF-EMF and diseases such as leukemia and other cancers,4-6 depression, and suicide,7 and neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis.8-11 All these results, though some of them were conflicting, resulted in a “melatonin hypothesis” as a tentative explanation, with the idea that those potential ELF-EMF deleterious effects might be a consequence of an inhibitory effect of ELF-EMF on the production of melatonin,12 a hormone whose secretion has been shown to be altered (concentration decline and/or alteration of its circadian rhythm) in some diseases including cancers (review in Hill et al, ref 13), depressive disorders,14-16 and disorders of the circadian time structure.17,18

The concern regarding public health resulted in reports on this matter of official organizations, the most recent reports being those of the International Agency for Research on Cancer (IARC) in 2002 and the World Health Organization in 2007.19 Of special interest, the IARC published in 2002 an evaluation of the carcinogenic risks of ELF to humans.20 The agency classified ELF electric fields into category 3, which in the classification corresponds to “inadequate evidence” of deleterious effects, and classified ELF magnetic fields into category 2B, corresponding to the category of agents that are “possibly carcinogenic to humans.” A classification into group 2B is “usually based on evidence in humans which is considered credible, but for which other explanations could not be ruled out.” It has to be noted that these extremely-low-frequency electric and magnetic fields are separate entities.

Whether or not ELF magnetic field exposure is causally related to increased health risks has led many scientists to examine the potential mechanisms by which ELF magnetic fields might affect human health. It is known that cancer and neurobehavioral alterations may be associated with circadian rhythm disruption and/or effect on melatonin secretion.21-24 Theoretically, melatonin could be a good mechanistic candidate to explain potentially deleterious effects of EMF since: i) its secretion is dramatically inhibited by light,25-28 which is the visible part of EMF; ii) the circadian pattern of the hormone is phase-advanced or -delayed by light according to the time of exposure, which is known as the phase response curve or PRC,29 and this property might occur with exposure to EMF; iii) the oncostatic properties of melatonin have been described,30-32 which resulted in the hypothesis that a decrease in the secretion of melatonin by the pineal gland might promote the development of breast cancer in humans12; iv) and last, its association with depressive, disorders has been put forward.14-16

Since both melatonin and cortisol are major markers of the circadian system, we reviewed data from the literature on these two marker rhythms, in search of deleterious effects of EMF on both their blood levels and abnormalities in their circadian profiles, eg, a phase-advance or a phase-delay which would point out a rhythm desynchronization of the organism, ie, a situation that occurs when the biological clock is no longer in step with its environment.17,33

Rationale for studying the effects of ELF-EMF on melatonin and cortisol secretions

Melatonin (N-acetyl 5- methoxytryptamine), a neurohormone produced by the pineal gland, is characterized by a prominent circadian rhythm with high levels at night and very low levels during the daytime, whatever the age.34,35 Its secretory pattern has a strong endogenous component and is physiologically controlled by light. Melatonin is therefore considered as a marker rhythm of the circadian temporal structure. A marker rhythm is a physiological rhythmic variable, whose circadian pattern is highly reproducible on an individual basis and as a group phenomenon, which thus allows characterization of the timing of the endogenous rhythmic time structure and provides information on the synchronization of individuals (Figure 1.).36 Besides melatonin, the most frequent marker rhythms used both in humans and animals are the core body temperature circadian pattern37 and the cortisol circadian rhythm, since they are also highly reproducible.36,17

Figure 1.
Reproducibility of the circadian patterns of plasma cortisol and melatonin in young healthy men. The circadian rhythms of the two hormones are highly reproducible from a day to another. Both are useful circadian markers of the time structure. Reproduced ...

Cortisol also displays a robust and highly reproducible circadian rhythm that does not respond rapidly to minor and transient environmental changes, as they are part of daily life, which also makes it a good candidate as a marker rhythm.36 Since a relationship between the pineal gland and the adrenal gland has been documented in vitro,38 and considering the hypothesis of the alteration of melatonin by EMF, it can be useful to look at their potential effects on cortisol, another rhythm marker of the circadian system, and to obtain an additional argument for a circadian desynchronization of the organism.

ELF-EMF effects on melatonin

Animal studies

For the sake of clarity, we present in two different tables the reports on ELF-EMF effects on melatonin. Table Ia displays the reports showing an alteration of melatonin secretion in different animal species, mainly rodents, after exposure to ELF-EMF. Table Ib deals with all of the studies reporting no effect of ELF-EMF on melatonin secretion in the different species under study.

Table Ia
Magnetic field reports on the modification of melatonin secretion in different animal species. Mel, melatonin; Pl, plasma; Ser, serum; aMT6s, 6 sulfatoxymelatonin; MF, magnetic field; NAT: serotonin N-acetyl transferase
Table Ib
Reports on the lack of effect of magnetic field on melatonin secretion in different animal species. Mel, melatonin; Pl, plasma; Ser, serum; aMT6s, 6 sulfatoxymelatonin; MF, magnetic field; NAT, serotonin N-acetyl transferase; NG, not given

The very first data on the topic deal with electric fields (not magnetic fields), and date back to 1981, with the report on the reduction of pineal melatonin and N-acetyltransferase (NAT), the key enzyme for melatonin synthesis, in rats exposed to electric fields 20 h/day for 30 days.39,40 Other reports, however, failed to find any effect, or were inconclusive or contradictory.41,42 Then the interest shifted from electric to magnetic fields, with a large number of studies devoted to the effects of ELF-EMF on melatonin levels in different animal species.43,44

Yellon45,46 and Wilson et al,47 documenting the effects of magnetic fields, were the first to report a reduction of both in pineal and plasma melatonin in Djungarian hamsters with a short exposure to a sinusoidal 100-μT magnetic field. In addition, Wilson et al47 also reported an increase in the concentration of norepinephrine in the suprachiasmatic nuclei, the central rhythm-generating system.

The majority of laboratory studies were then carried out on rats. Kato et al,48 in exposing male Wistar-King rats for 6 weeks to a 50-Hz circularly polarized sinusoidal magnetic field using increasing intensities, showed a decrease in pineal and plasma melatonin concentrations without any dose-response relationship. With the same protocol of exposure and species, but with a horizontal or vertical magnetic field, the same authors failed to find any effect on melatonin levels:49 Suspecting a possible interference of pigmentation, Kato et al50,51 then documented in Long-Evans rats the same intensities of a circularly polarized magnetic field and did indeed show a reduction of pineal and plasma melatonin concentrations. Other studies on rats or mice,52-55 baboons,56 and hamsters57,58 also showed a reduction in the nighttime peak of melatonin. The same team reported a phase delay in the nocturnal peak time of melatonin in hamsters,46,57,58 though they acknowledged in one paper that they were unable to replicate these findings, which make them inconclusive.58 Some authors have reported an increase in nighttime melatonin levels.59-61

With the aim of comparing short-term and long-term exposure effects, Selmaoui and Touitou62 used male Wistar rats housed in a 12:12 light:dark schedule and submitted to a 50-Hz sinusoidal magnetic field of 1, 10, or 100 μT intensity, either once for 12 h or repeatedly 18 h per day for 30 days. While a single 12-h exposure to a 1- or 10-μT magnetic field had no effect on plasma melatonin levels or NAT and hydroxyindole-O-methyltransferase (HIOMT) pineal activities, a 100-μT exposure significantly decreased 30% plasma concentrations of melatonin and depressed 23% pineal NAT activity (HIOMT activity unchanged) when compared with sham-exposed rats. In turn, the 30 days' repeated exposure showed that while the 1-μT intensity showed no effects on pineal function, both the 10- and 100-μT intensities resulted in an approximately 42% decrease of plasma melatonin levels. NAT activity was also decreased, and HIOMT activity remained unchanged. This study showed that a sinusoidal magnetic field alters plasma melatonin levels and pineal NAT activity, and that the sensitivity threshold varies with the duration of exposure, thus suggesting that magnetic fields may have a cumulative effect upon pineal function. This melatonin and NAT activity decrease was able to be replicated in adult rats in another study by Selmaoui and Touitou,63 while they also reported that aged rats were not affected by ELF-EMF. Löscher et al53 studied the effects of a 24 h/day, 7 days/week, and 3-month exposure to magnetic fields on female rats bearing DMBA-induced mammary tumors; the field intensities were similar to the domestic exposures recorded close to electric power facilities. Whereas a significant decrease of blood melatonin concentrations was observed with 1 μT, no influence on the development of the mammary tumors could be put in evidence.

Table lb presents data on different animal species reporting the lack of effect of ELF-EMF on the concentrations of pineal or blood melatonin and on the urinary concentration of 6-sulphatoxymelatonin, the main metabolite of the hormone. These reports were either inconsistent or failed to show any effect of ELF-EMF in species as different as rats or mice,64-73 sheep,74,75 baboons,76 Djungarian hamsters,58,77 cows or heifers,78-80 and kestrels.81,82

The comparison of Table la (effects on melatonin) and Table lb (lack of effects on melatonin) clearly shows that a number of these studies resulted in inconsistent data, even when the data were replicated by the same team with the same protocol and characteristics of exposure.48,49,57,58,83,84

Last, some authors studying the effects of exposure to ELF-EMF of various biological systems such as isolated pineal glands85-90 or MCF-7 cells91-96 were unable to arrive at definite conclusions (Table II).

Table II.
Effects of magnetic fields on various biological systems in vitro. NE, norepinephrine; Mel: melatonin

Human studies

Much of the evidence for the melatonin hypothesis is based on data obtained in rodents with a 25% to 40% reduction in the hormonal concentration, though, as shown above, results on the effects of ELF-EMF in rodents and higher mammals provided controversial results. Since the 1990s several research papers have documented the effects of ELF-EMF on the secretion of melatonin in humans. Most research published has involved an acute exposure (from 30 min to 4 days on average) of healthy volunteers to ELF-EMF with different exposure characteristics (Tables IIIa and IIIb). The data on humans are controversial, since of the papers published about one third reported a decrease in melatonin secretion97-107 with, however, some comments to be mentioned such as the lack of evidence for a dose-response,97 or a decrease not exclusively related to ELF-EMF and found in some particular subgroups98-107 (Table IIIa). In contrast to the previous ones, two thirds of the reports failed to find any effect of ELF-EMF on melatonin secretion in humans ( Table IIIb). 108-130Most work published on humans dealt with short-term exposure for evident ethical reasons. Taking into account the data we have shown on rats of potentially cumulative effects of ELF-EMF,62 we performed a study in workers chronically exposed daily for 1 to 20 years, both in the workplace and at home, since the workers were housed near the substations. We showed no alteration in their melatonin secretion (plasma level or circadian profiles) which strongly suggests that ELF-EMF do not have cumulative effects on melatonin secretion in humans, and thus clearly rebuts the melatonin hypothesis that a decrease in blood melatonin concentration (or a disruption in its secretory pattern) explains the occurrence of clinical disorders or cancers possibly related to ELF-EMF.125

Table IIIa.
Magnetic field reports on a melatonin secretion decrease in humans. Mel, melatonin; aMT6s, 6 sulfatoxymelatonin; M, male; F: female; MF, magnetic field; NG, not given
Table IIIb.
Magnetic field reports on the lack of effect on melatonin secretion in humans. Mel, melatonin; Pl, plasma; Ser, serum; Sal, saliva; aMT6s, 6 sulfatoxymelatonin; M, male; F, female; BMI, body mass index; MF, magnetic field; RF, radio frequency; NG, not ...

ELF-EMF effects on cortisol and corticosterone

In contrast to the number of studies on the effects of ELF-EMF on melatonin secretion, few data are available in the literature on the pituitary adrenal axis. The hormones under study (corticosterone for rats, cortisol for other mammals), exposure characteristics (short- and long-term), and timing and duration of exposure (1 to 6 months) in different animal species are detailed in Table IV.

Table IV.
Effects of EMF on cortisol or corticosterone secretion in different animal species. Pl, plasma; Se, serum; NG, not given

While the majority of papers failed to find any effect,131-137 others have reported either an increase in the hormonal concentrations138-144 or a decreased concentration.145 The results of these studies are thus inconsistent and contradictory. Comparison between studies revealed that the discrepancy in the results might be due in part to the difference in the animal species used (rabbit, ewe lambs, cows, rats, or mice), class of age, and duration and intensity of exposure. Another factor that should be taken into account is that glucorticoids (ie, cortisol or corticosterone) levels are sensitive to many stressors that might affect hormone levels. It is well known that handling or bleeding animals increase corticosterone, a stress marker, and it is thus important to ensure that any external confounding stressor has to be controlled.

Overall, these data suggest that no consistent effects have been seen in the stress-related hormones of the pituitary-adrenal axis in a variety of mammalian species. Data on ELF-EMF effects on cortisol in humans are scarce. We have found 7 papers on the matter (Table V).109,124,146-149 All of these papers report only on short exposure of adult volunteers to ELF-EMF, and all failed to find any effect.

Table V.
Magnetic field reports on cortisol secretion in humans. Ser, serum; Pl, plasma; M, male; F, female; MF, magnetic field


We are all exposed to electric and magnetic fields of weak intensity. The levels of exposure of the general population range from 5 to 50 V/m for electric fields and from 0.01 to 0.2 μT for magnetic fields. The possible risk on health with exposure to electromagnetic fields became a concern to the public, which led to numerous studies by scientists on the topic. We have shown in this review that the reported studies are largely contradictory with regard to epidemiologic studies (about half of the studies found a relationship and the other half failed to find any), to the potential biological effects of ELF-EMF, and to the potentially mechanisms put forward; no clear explanations exist for these contradictory results. The relative risk (RR) which establishes the relation between exposure to ELF-EMF and cancer, is approximately 2 to 3. In the absence of clear explanation(s) a number of hypotheses have been raised. The characteristics of the magnetic field (linear or circular polarization, duration, timing), the animal species and, within a species, the strain appears to have a role in determining the biologic response obtained. Therefore, great care must be given when comparing data obtained in different animal species, even within a group as rodents, since differences have been described between rodent species and even between pigmented and albino breeds.

A possible change in the spatial structure of the photoreceptor pigment rhodopsin due to the electric field induced by the magnetic field has been proposed. Magnetic fields might also change either the electrical activity of the pinealocytes or their ability to produce melatonin, or both. With regard to the numerous studies performed on the effects of ELF-EMF on melatonin, the differences observed in animals and humans in these effects may be due to the differences in anatomical location and configuration of the pineal gland, and also the difference in the rest-activity cycle between rodents and humans. A different sensitivity to ELF-EMF could also be part of the explanation. Some human subjects may have greater sensitivity to ELF-EMF, but this is difficult to demonstrate because of the important interindividual variability in plasma concentration of melatonin. As far as melatonin is concerned, we have shown a lack of effect of ELF-EMF on melatonin (concentration and circadian rhythm) in workers exposed daily for up to 20 years in their workplace and at home, which strongly suggests that chronic ELF-EMF exposure appears to have no cumulative effects in human adults; this rebuts the “melatonin hypothesis” raised as an explanation for the deleterious sanitary effects of ELF-EMF.125

In the same way, the application of high-throughput omics technologies to investigate the influences of ELF-EMF is confronted with the heterogeneity among the biological materials investigated, which are as different as blood cells/vessels, tissue cells, nerves, and bacteria, and this makes it difficult to compare data and to arrive at firm conclusions on the potential effects of ELF-EMF on biological systems.150 As an example, most breast tumors become, resistant to tamoxifen, and it has been shown that ELF-EMF reduce the efficacy of tamoxifen in a manner similar to tamoxifen resistance. By exposing cells of the breast cancer line MCF-7 to ELF-EMF, it has been found that ELF-EMF alter the expression of estrogen receptor cofactors, which in the authors' view may contribute to the induction of tamoxifen resistance in vivo.151

Currently, the debate concerns the effects of ELF-EMF on children, with some data published in the literature pointing out the risk of childhood leukemia in relation to residential exposure, and underlining that this risk (the RR is around 2) can exist when children are chronically exposed to more than 0.4 μT.10 Large-scale collaborative studies are still needed to fill the gaps in our knowledge and provide answers to these numerous questions not yet resolved. Last, the deleterious risk of ELF-EMF on frail populations such as children and aged people may be greater and should be documented, at least for their residential exposure.

Figure 2.
Effects of chronic exposure of male rats to a sinusoidal 50-Hz magnetic field ( from 1 to 100 uT) on nocturnal pineal activity. The rats were exposed every day from 14:00 to 08:00 for 30 days at three different intensities. Only 10 and 1 00 uT were able ...
Figure 3.
Nocturnal plasma melatonin patterns (A) and 6-sulfatoxymelatonin concentration (6SM; B) in the first-void morning urine (20:00 to 08:00). This study was carried out in 15 healthy chronically (in the workplace and at home) exposed men (daily and for 1 ...


1. Wertheimer N., Leeper E. Electrical wiring configurations and childhood cancer. Am J Epidemiol. 1979;109:273–284. [PubMed]
2. Wertheimer N., Leeper E. Adult cancer related to electrical wires near the home. Int J Epidemiol. 1982;11:345–355. [PubMed]
3. Savitz DA., Wachtel H., Barnes FA., John EM., Tvrdik JG. Case control study of childhood cancer and exposure to 60-Hz magnetic fields. Am J Epidemiol. 1988;128:21–38. [PubMed]
4. Ahlbom A., Day N., Feychting M., et al. A pooled analysis of magnetic fields and childhood leukemia. Br J Cancer. 2000;83:692–698. [PMC free article] [PubMed]
5. Linet MS., Hatch EE., Kleinerman RA., et al. Residential exposure to magnetic fields and acute lymphoblastic leukemia in children. N Engl J Med. 1997;337:1–7. [PubMed]
6. McBride ML., Gallagher RP., Theriault G., et al. Power-frequency electric and magnetic fields and risk of childhood leukemia in Canada. Am J Epidemiol. 1999;149:831–842. [PubMed]
7. Reichmanis M., Perry FS., Marino AA., Becker RO. Relation between suicide and the electromagnetic field of overhead power lines. Physiol Chern Pfiys. 1979;11:395–403. [PubMed]
8. Sobel E., Dunn M., Davanipour Z., Qian Z., Chui H. Elevated risk of Alzheimer's disease among workers with likely electromagnetic exposure. Neurology. 1996;47:1477–1481. [PubMed]
9. Davanipour Z., Sobel E. Long-term exposure to magnetic fields and the risks of Alzheimer's disease and breast cancer: further biological research. Pathophysiology. 2009;16:149–156. [PubMed]
10. Kheifets L., Ahlbom A., Crespi CM., et al. Pooled analysis of recent studies on magnetic fields and childhood leukaemia. Br J Cancer. 2010;103:1128–1135. [PMC free article] [PubMed]
11. Kheifets L., Renew D., Sias G., Swanson J. Extremely low frequency electric fields and cancer: assessing the evidence. Bioelectromagnetics. 2010;31:89–101. [PubMed]
12. Stevens RG., Davies S. The melatonin hypothesis: electric power and breast cancer. Enviro Health Perspect. 1996;104:135–140. [PMC free article] [PubMed]
13. Hill SM., Blask DE., Xiang S., et al. Melatonin and associated signaling pathways that control normal breast epithelium and breast cancer. J Mammary Gland Biol Neoplasia. 2011;16:235–245. [PubMed]
14. Wehr TA., Godwin FK. American Handbook of Psychiatry. Vol 7. 2nd ed. New York, NY: Basic Books. 1981:46–74.
15. Lewy AJ., Wehr TA., Goodwin FK., Newsome DA., Rosenthal NE. Manic depressive patients may be supersensitive to light. Lancet. 1981;106:145–151. [PubMed]
16. Claustrat B., Chazot G., Brun J. A chronobiological study of melatonin and cortisol secretion in depressed subjects: plasma melatonin, a biochemical marker in major depression. Biol Psychiatry. 1984;19:1215–1228. [PubMed]
17. Touitou Y., Coste O., Dispersyn G., Pain L. Disruption of the circadian system by environmental factors: effects of hypoxia, magnetic fields and general anesthetics agents. Adv Drug Deliv Rev. 2010;62:928–945. [PubMed]
18. Touitou Y. Desynchronisation de l'horloge interne, lumiere et melatonine. Bull Acad Nle Med. 2011;195:1527–1549. [PubMed]
19. World Health Organization. Extremely low frequency fields (Environment health criteria 238). Geneva, Switzerland: World Health Organisation. 2007
20. International agency for research on cancer (IARC). Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 80 Non-Ionizing Radiation. Part 1: Static and Extremely Low-Frequency (ELF) Electric and Magnetic Fields. [PubMed]
21. Wilson BW., Stevens RG., Anderson LE. Neuroendocrine mediated effects of electromagnetic-field exposure: possible role of the pineal gland. Life Sci. 1989;45:1319–1332. [PubMed]
22. Touitou Y., Levi F., Bogdan A., Benavides M., Bailleul F., Misset JL. Rhythm alteration in patients with metastatic breast cancer and poor prognostic factors. J Cancer Res Clin Oncol. 1995;121:181–188. [PubMed]
23. Touitou Y., Bogdan A., Levi F., Benavides M., Auzeby A. Disruption of the circadian patterns of serum cortisol in breast and ovarian cancer patients relationships with tumor marker antigens. Br J Cancer. 1996;74:1248–1252. [PMC free article] [PubMed]
24. Mormont MC., Langouet AM., Claustrat B., et al. Marker rhythms of circadian system function: a study of patients with metastatic colorectal cancer and good performance status. Chronobiol Int. 2002;19:141–155. [PubMed]
25. Lewy AJ., Wehr TA., Goodwin FK., Newsome DA., Markey SP. Light suppresses melatonin secretion in humans. Science. 1980;210:1267–1269. [PubMed]
26. Touitou Y., Benoit O., Foret J., et al. Effects of 2 hour early awakening and bright light exposure on plasma patterns of cortisol, melatonin, prolactin and testosterone in man. Acta Endocrinol. 1992;126:201–205. [PubMed]
27. Lemmer B., Bruhl T., Pflug B., Kohler W., Touitou Y. Effects of bright light on circadian patterns of cyclic adenosine monophosphate, melatonin and cortisol in healthy subjects. Eur J Endocrinol. 1994;130:472–477. [PubMed]
28. Depres-Brummer P., Levi F., Metzger G., Touitou Y. Light-induced suppression of the rat circadian system . Am J Physiol. 1995;37:R1111–R1116. [PubMed]
29. Touitou Y., Arendt J., Pevet P. Melatonin and the Pineal Gland: from Basic Science to Clinical Applications. Amsterdam, the Netherlands: Elsevier. 1993
30. Rodin AE. The growth and spread of walker 256 carcinoma in pinealectomized rats. Cancer Res. 1963;23:1545. Abstract. . [PubMed]
31. Das Gupta TK., Terz J. Influence of the pineal gland on growth and spread of melatonin in the hamster. Cancer Res. 1967;27:1306–1311. [PubMed]
32. Tamarkin L., Cohen M., Roselle D., Reichert C., Lippman M., Chabner B. Melatonin inhibition and pinealectomy enhancement of 7, 12-dimethylbenz(a)anthraceneinduced mammary tumors in the rat. Cancer Res. 1981;41:4432–4436. [PubMed]
33. Reinberg AE., Touitou Y. Synchronisation et dyschronisme des rythmes circadiens humains. Pathol Biol. 1996;44:487–495. [PubMed]
34. Touitou Y., Sulon J., Bogdan A., et al. Adrenal circadian system in young and elderly human subjects: a comparative study. J Endocrinol. 1982;93:201–210. [PubMed]
35. Touitou Y., Sulon J., Bogdan A., Reinberg A., Sodoyez JC., Demey-Ponsart E. Adrenocortical hormones ageing and mental condition: seasonal and circadian rhythms of plasma 18-hydroxy-11 deoxycorticosterone, total and free cortisol and urinary corticosteroid. J Endocrinol. 1983;96:53–64. [PubMed]
36. Selmaoui B., Touitou Y. Reproducibility of the circadian rhythms of serum cortisol and melatonin in healthy subjects. A study of three different 24-h cycles over six weeks. Life Sci. 2003;73: 3339–3349. [PubMed]
37. Mailloux A., Benstaali C., Bogdan A., Auzeby A., Touitou Y. Body temperature and locomotor activity as marker rhythms of aging of the circadian system in rodents. Exp Gerontol. 1999;34:733–740. [PubMed]
38. Touitou Y. Pineal and hypothalamo-pituitary-adrenal axis: in search for interaction. In: Reiter RJ, Pang SF, eds. Advances in Pineal Research. Vol 3. London, UK: John Libbey, 1989:241–246.
39. Wilson BW., Anderson LE., Hilton Dl., Phillips RD. Chronic exposure to 60Hz electric fields: effects on pineal function in the rat. Bioelectromagnetics. 1981;2:371–380. [PubMed]
40. Wilson BW., Chess EK., Anderson LE. 60-Hz electric-field effects on pineal melatonin rhythms: time course for onset and recovery. Bioelectromagnetics. 1986;7:239–242. [PubMed]
41. Reiter RJ., Anderson LE., Buschbom RL., Wilson BW. Reduction of the nocturnal rise in pineal melatonin levels in rats exposed to 60-Hz electric fields in utero and for 23 days after birth. Life Sci. 1988;42:2203–2206. [PubMed]
42. Grata LJ., Reiter RJ., Keng P., Michaelson S. Electric field exposure alters serum melatonin but not pineal melatonin synthesis in male rats. Bioelectromagnetics. 1994;15:427–437. [PubMed]
43. Touitou Y., Bogdan A., Lambrozo J., Selmaoui B. Is melatonin the hormonal missing link between magnetic field effects and human diseases. Cancer Causes Control. 2006;17:547–552. [PubMed]
44. Lambrozo J., Touitou Y., Dab W. Exploring the EMF-melatonin connection: a review of the possible effects of 50/60-Hz Electric and magnetic fields on melatonin secretion. IntJOccup Environ Health. 1996;2:37–47. [PubMed]
45. Yellon SM., Gottfried L. An Acute 60 Hz exposure suppresses the nighttime melatonin rhythm in the adult djungarian hamster in short days. Annual Review of Research on Biological Effects of Electric and Magnetic Fields from the Generation, Delivery and Use of Electricity. US Department of Energy: A-22, San Diego, California: 1992; November 8-12
46. Yellon SM. Acute 60 Hz magnetic field exposure effects on the melatonin rhythm in the pineal gland and circulation of the adult Djungarian hamster. J Pineal Res. 1994;16:136–144. [PubMed]
47. Wilson BW., Morris JE., Sasser LB., et al. Changes in the hypothalamus and pineal gland on Djungarian hamsters from short-term exposure to 60 Hz magnetic field. Annual Review of Research on Biological Effects of Electric and Magnetic Fields from the Generation, Delivery and Use of Electricity. US Department of Energy: A-30, Savannah. Georgia. 1993; October 31-November 4
48. Kato M., Honma K., Shigemitsu T., et al. Effects of exposure to a circularly polarized 50-Hz magnetic field on plasma and pineal melatonin levels in rats. Bioelectromagnetics. 1993;14:97–106. [PubMed]
49. Kato M., Honma K., Shigemitsu T., Shiga Y. Horizontal or vertical 50-Hz, 1-microT magnetic fields have no effect on pineal gland or plasma melatonin concentration of albino rats. Neurosci Lett. 1994;168:205–208. [PubMed]
50. Kato M., Honma K., Shigemitsu T., Shiga Y. Circularly polarized 50-Hz magnetic field exposure reduces pineal gland and blood melatonin concentrations of Long-Evans rats. Neurosci Lett. 1994;166:59–62. [PubMed]
51. Kato M., Honma K., Shigemitsu T., Shiga Y. Recovery of nocturnal melatonin concentration takes place within one week following cessation of 50 Hz circularly polarized magnetic field exposure for six weeks. Bioelectromagnetics. 1994;15:489–492 . [PubMed]
52. Martinez Soriano F., Gimenez Gonzalez M., Armanazas E., Ruiz Torner A. Pineal 'synaptic ribbons' and serum melatonin levels in the rat following the pulse action of 52-Gs (50-Hz) magnetic fields: an evolutive analysis over 21 days. Acta Anat (Basel). 1992;143:289–293. [PubMed]
53. Loscher W., Wahnschaffe U., Mevissen M., Lerchl A., Stamm A. Effects of weak alternating magnetic fields on nocturnal melatonin production and mammary carcinogenesis in rats. Oncology. 1994;51:288–295. [PubMed]
54. Huuskonen H., Saastamoinen V., Komulainen H., Laitinen J., Juutilainen J. Effects of low-frequency magnetic fields on implantation in rats. Reprod Toxicol. 2001;15:49–59. [PubMed]
55. Kumlin T., Heikkinen P., Laitinen JT., Juutilainen J. Exposure to a 50-hz magnetic field induces a circadian rhythm in 6-hydroxymelatonin sulfate excretion in. mice. J Radiat Res. 2005;46:313–318. [PubMed]
56. Rogers WR., Reiter RJ., Barlow-Walden L., Smith HD., Orr JL. Regularly scheduled, day-time, slow-onset 60 Hz electric and magnetic field exposure does not depress serum melatonin concentration in nonhuman primates. Bioelectromagnetics. 1995;(suppl 3):111–118. [PubMed]
57. Truong H., Smith JC., Yellon SM. Photoperiod control of the melatonin rhythm and reproductive maturation in the juvenile Djungarian hamster: 60-Hz magnetic field exposure effects. Biol Reprod. 1996;55:455–460. [PubMed]
58. Yellon SM. 60-Hz magnetic field exposure effects on the melatonin rhythm and photoperiod control of reproduction. Am J Physiol. 1996;270:E816–E821. [PubMed]
59. Niehaus M., Bruggemeyer H., Behre HM., Lerchl A. Growth retardation, testicular stimulation, and increased melatonin synthesis by weak magnetic fields (50 Hz) in Djungarian hamsters, Phodopus sungorus. Biochem Biophys Res Commun. 1997;234:707–711. [PubMed]
60. Lerchl A., Zachmann A., AM MA., Reiter RJ. The effects of pulsing magnetic fields on pineal melatonin synthesis in a teleost fish (brook trout, Salvelinus fontinalis). Neurosci Lett. 1998;256:171–173. [PubMed]
61. Dyche J., Anch AM., Fogler KA., Barnett DW., Thomas C. Effects of power frequency electromagnetic fields on melatonin and sleep in the rat. Emerg Health Threats J. Epub 2012 Apr 20. [PMC free article] [PubMed]
62. Selmaoui B., Touitou Y. Sinusoidal 50-Hz magnetic fields depress rat pineal NAT activity and serum melatonin. Role of duration and intensity of exposure. Life Sci. 1995;57:1351–1358. [PubMed]
63. Selmaoui B., Touitou Y. Age-related differences in serum melatonin and pineal NAT activity and in the response of rat pineal to a 50-Hz magnetic field. Life Sci. 1999;64:2291–2297. [PubMed]
64. Bakos J., Nagy N., Thuroczy G., Szabo LD. Sinusoidal 50 Hz, 500 microT magnetic field has no acute effect on urinary 6-sulphatoxymelatonin in Wistar rats. Bioelectromagnetics. 1995;16:377–380. [PubMed]
65. Bakos J., Nagy N., Thuroczy G., Szabo LD. Urinary 6-sulphatoxymelatonin excretion is increased in rats after 24 hours of exposure to vertical 50 Hz, 100 microT magnetic field. Bioelectromagnetics. 1997;18:190–202. [PubMed]
66. Bakos J., Nagy N., Thuroczy G., Szabo LD. One week of exposure to 50 Hz, vertical magnetic field does not reduce urinary 6-sulphatoxymelatonin excretion of male wistar rats. Bioelectromagnetics. 2002;23:245–248. [PubMed]
67. Fedrowitz M., Westermann J., Loscher W. Magnetic field exposure increases cell proliferation but does not affect melatonin levels in the mammary gland of female Sprague Dawley rats. Cancer Res. 2002;62:1356–1363. [PubMed]
68. Kroeker G., Parkinson D., Vriend J., Peeling J. Neurochemical effects of static magnetic field exposure. Surg Neurol. 1996;45:62–66. [PubMed]
69. Loscher W., Mevissen M., Lerchl A. Exposure of female rats to a 100microT 50 Hz magnetic field does not induce consistent changes in nocturnal levels of melatonin. Radiat Res. 1998;150:557–567. [PubMed]
70. John TM., Liu GY., Brown GM. 60 Hz magnetic field exposure and urinary 6-sulphatoxymelatonin levels in the rat. Bioelectromagnetics. 1998;19:172–180. [PubMed]
71. Mevissen M., Lerchl A., Loscher W. Study on pineal function and DMBAinduced breast cancer formation in rats during exposure to a 100-mG, 50 Hz magnetic field. J Toxicol Environ Health. 1996;48:169–185. [PubMed]
72. Mevissen M., Lerchl A., Szamel M., Loscher W. Exposure of DMBA-treated female rats in a 50-Hz, 50 microTesIa magnetic field: effects on mammary tumor growth, melatonin levels, and T lymphocyte activation. Carcinogenesis. 1996;17:903–910. [PubMed]
73. de Bruyn L., de Jager L., Kuyl JM. The influence of long-term exposure of mice to randomly varied power frequency magnetic fields on their nocturnal melatonin secretion patterns. Environ Res. 2001;85:115–121. [PubMed]
74. LeeJM Jr., Stormshak F., Thompson JM., Thinesen P., et al. Melatonin secretion and puberty in female lambs exposed to environmental electric and magnetic fields. Biol Reprod. 1993;49:857–864. [PubMed]
75. LeeJM Jr., Stormshak F., Thompson JM., Hess DL., Foster DL. Melatonin and puberty in female lambs exposed to EMF: a replicate study. Bioelectromagnetics. 1995;16:119–123. [PubMed]
76. Rogers WR., Reiter RJ., Smith HD., Barlow-Walden L. Rapid-onset/offset, variably scheduled 60 Hz electric and magnetic field exposure reduces nocturnal serum melatonin concentration in nonhuman primates. Bioelectromagnetics. 1995;(Suppl 3):119–122. [PubMed]
77. Yellon SM., Truong HN. Melatonin rhythm onset in the adult Siberian hamster: influence of photoperiod but not 60-Hz magnetic field exposure on melatonin content in the pineal gland and in circulation. J Biol Rhythms. 1998;13:52–59. [PubMed]
78. Burchard JF., Nguyen DH., Block E. Effects of electric and magnetic fields on nocturnal melatonin concentrations in dairy cows. J Dairy Sci. 1998;81:722–727. [PubMed]
79. Burchard JF., Nguyen DH., Monardes HG. Exposure of pregnant dairy heifer to magnetic fields at 60 Hz and 30 microT. Bioelectromagnetics. 2007;28:471–476. [PubMed]
80. Rodriguez M., Petitclerc D., Burchard JF., Nguyen DH., Block E. Blood melatonin and prolactin concentrations in dairy cows exposed to 60 Hz electric and magnetic fields during 8 h photoperiods. Bioelectromagnetics. 2004;25:508–515. [PubMed]
81. Fernie KJ., Bird DM., Petitclerc D. Effects of electromagnetic fields on photophasic circulating melatonin levels in American kestrels. Environ Health Perspect. 1999;107:901–904. [PMC free article] [PubMed]
82. Dell'Omo G., Costantini D., Lucini V., Antonucci G., Nonno R., Polichetti A. Magnetic fields produced by power lines do not affect growth, serum melatonin, leukocytes and fledging success in wild kestrels. Cornp Biochem Physiol C Toxicol Pharmacol. 2009;150:372–376. [PubMed]
83. Reiter RJ., Tan DX., Poeggeler B., Kavet R. Inconsistent suppression of nocturnal pineal melatonin synthesis and serum melatonin levels in rats exposed to pulsed DC magnetic fields. Bioelectromagnetics. 1998;19:318–329. [PubMed]
84. Burchard JF., Nguyen DH., Monardes HG., Petitclerc D. Lack of effect of 10 kV/m 60 Hz electric field exposure on pregnant dairy heifer hormones. Bioelectromagnetics. 2004;25:308–312. [PubMed]
85. Lerchl A., Nonaka KO., Reiter RJ. Pineal gland “magnetosensitivity” to static magnetic fields is a consequence of induced electric currents (eddy currents). J Pineal Res. 1991;10:109–116. [PubMed]
86. Richardson BA., Yaga K., Reiter RJ., Morton DJ. Pulsed static magnetic field effects on in-vitro pineal indoleamine metabolism. Biochim Biophys Acta. 1992;1137:59–64. [PubMed]
87. Rosen LA., Barber I., Lyle DB. A 0.5 G, 60 Hz magnetic field suppresses melatonin production in Bioelectromagnetics. 1998;19:123–127. [PubMed]
88. Brendel H., Niehaus M., Lerchl A. Direct suppressive effects of weak magnetic fields (50 Hz and 16 2/3 Hz) on melatonin synthesis in the pineal gland of Djungarian hamsters (Phodopus sungorus). J Pineal Res. 2000;29:228–233. [PubMed]
89. Lewy H., Massot O., Touitou Y. Magnetic field (50 Hz) increases N-acetyltransferase, hydroxy-indole-O-methyltransferase activity and melatonin release through an indirect pathway. Int J Radiat Biol. 2003;79:431–435. [PubMed]
90. Tripp HM., Warman GR., Arendt J. Circularly polarised MF (500 micro T 50 Hz) does not acutely suppress melatonin secretion from cultured Wistar rat pineal glands. Bioelectromagnetics. 2003;24:118–124. [PubMed]
91. Liburdy RP., Sloma TR., Sokolic R., Yaswen P. ELF magnetic fields, breast cancer, and melatonin: 60 Hz fields block melatonin's oncostatic action on ER+ breast cancer cell proliferation. J Pineal Res. 1993;14:89–97. [PubMed]
92. Harland JD., Liburdy RP. Environmental magnetic fields inhibit the antiproliferative action of tamoxifen and melatonin in a human breast cancer cell line. Bioelectromagnetics. 1997;18:555–562. [PubMed]
93. Blackman CF., Benane SG., House DE. The influence of 1.2 microT, 60 Hz magnetic fields on melatonin- and tamoxifen-induced inhibition of MCF7 cell growth. Bioelectromagnetics. 2001;22:122–128. [PubMed]
94. Ishido M., Nitta H., Kabuto M. Magnetic fields (MF) of 50 Hz at 1.2 microT as well as 100 microT cause uncoupling of inhibitory pathways of adenylyl cyclase mediated by melatonin 1a receptor in MF-sensitive MCF-7 cells. Carcinogenesis. 2001;22:1043–1048. [PubMed]
95. Leman ES., Sisken BF., Zimmer S., Anderson KW. Studies of the interactions between melatonin and 2 Hz, 0.3 inT PEMF on the proliferation and invasion of human breast cancer cells. Bioelectromagnetics. 2001;22:178–84. [PubMed]
96. Girgert R., Hanf V., Ernons G., Grundker C. Signal transduction of the melatonin receptor MT1 is disrupted in breast cancer cells by electromagnetic fields. Bioelectromagnetics. 2010;31:237–245. [PubMed]
97. Pfluger DH., Minder CE. Effects of exposure to 16.7 Hz magnetic fields on urinary 6-hydroxymelatonin sulfate excretion of Swiss railway workers. J Pineal Res. 1996;21:91–100. [PubMed]
98. Arnetz BB., Berg M. Melatonin and adrenocorticotropic hormone levels in video display unit workers during work and leisure. J Occup Environ Med. 1996;38:1108–1110. [PubMed]
99. Wood AW., Armstrong SM., Sait ML., Devine L., Martin MJ. Changes in human plasma melatonin profiles in response to 50 Hz magnetic field exposure. J Pineal Res. 1998;25:116–127. [PubMed]
100. Burch JB., Reif JS., Yost MG., Keefe TJ., Pitrat CA. Nocturnal excretion of a urinary melatonin metabolite among electric utility workers. ScandJ Work Environ Health. 1998;24:183–189. [PubMed]
101. Burch JB., Reif JS., Yost MG., Keefe TJ., Pitrat CA. Reduced excretion of a melatonin metabolite in workers exposed to 60 Hz magnetic fields. Am J Epidemiol. 1999;150:27–36. [PubMed]
102. Burch JB., Reif JS., Noonan CW., Yost MG. Melatonin metabolite levels in workers exposed to 60-Hz magnetic fields: work in substations and with 3phase conductors. J Occup Environ Med. 2000;42:136–142. [PubMed]
103. Juutilainen J., Stevens RG., Anderson LE., Hansen NH., Kilpelainen M., Kumlin T., Laitinen JT., Sobel E., Wilson BW. Nocturnal 6-hydroxymelatonin sulfate excretion in female workers exposed to magnetic fields. J Pineal Res. 2000;28:97–104. [PubMed]
104. Davis S., Kaune WT., Mirick DK., Chen C., Stevens RG. Residential magnetic fields, light-at-night, and nocturnal urinary 6-sulfatoxymelatonin concentration in women. Am J Epidemiol. 2001;154:591–600. [PubMed]
105. Burch JB., Reif JS., Noonan CW., Ichinose T., Bachand AM., Koleber TL., Yost MG. Melatonin metabolite excretion among cellular telephone users. IntJ Radiat Biol. 2002;78:1029–1036. [PubMed]
106. Davis S., Mirick DK., Chen C., Stanczyk FZ. Effects of 60-Hz magnetic field exposure on nocturnal 6-sulfatoxymelatonin, estrogens, luteinizing hormone, and follicle-stimulating hormone in healthy reproductive-age women: results of a crossover trial. Ann Epidemiol. 2006;16:622–631. [PubMed]
107. Burch JB., Reif JS., Yost MG. Geomagnetic activity and human melatonin metabolite excretion. Neurosci Lett. 2008;438:76–79. [PubMed]
108. Wilson BW., Wright CW., Morris JE., et al. Evidence for an effect of ELF electromagnetic fields on human pineal gland function. J Pineal Res. 1990;9:259–269. [PubMed]
109. Schiffman JS., Lasch HM., Rollag MD., Flanders AE., Brainard GC., Burk DL Jr. Effect of MR imaging on the normal human pineal body: measurement of plasma melatonin levels. J Magn Reson Imaging. 1994;4:7–11. [PubMed]
110. Selmaoui B., Lambrozo J., Touitou Y. Magnetic fields and pineal function in humans: evaluation of nocturnal acute exposure to extremely low frequency magnetic fields on serum melatonin and urinary 6-sulfatoxymelatonin circadian rhythms. Life Sci. 1996;58:1539–1549. [PubMed]
111. Graham C., Cook MR., Riffle DW., Gerkovich MM., Cohen HD. Nocturnal melatonin levels in human volunteers exposed to intermittent 60 Hz magnetic fields. Bioelectromagnetics. 1996;17:263–273. [PubMed]
112. Graham C., Cook MR., Riffle DW. Human melatonin during continuous magnetic field exposure. Bioelectromagnetics. 1997;18:166–171. [PubMed]
113. Akerstedt T., Arnetz B., Ficca G., Paulsson LE., Kallner A. A 50-Hz electromagnetic field impairs sleep. J Sleep Res. 1999;8:77–81. [PubMed]
114. Graham C., Cook MR., Sastre A., Riffle DW., Gerkovich MM. Multi-night exposure to 60 Hz magnetic fields: effects on melatonin and its enzymatic metabolite. J Pineal Res. 2000;28:1–8. [PubMed]
115. Crasson M., Beckers V., Pequeux C., Claustrat B., Legros JJ. Daytime 50 Hz magnetic field exposure and plasma melatonin and urinary 6-sulfatoxymelatonin concentration profiles in humans. J Pineal Res. 2001;31:234–241. [PubMed]
116. Graham C., Cook MR., Gerkovich MM., Sastre A. Melatonin and 6-OHMS in high-intensity magnetic fields. J Pineal Res. 2001;31:85–88. [PubMed]
117. Graham C., Sastre A., Cook MR., Gerkovich MM. All-night exposure to EMF does not alter urinary melatonin, 6-OHMS or immune measures in older men and women. J Pineal Res. 2001;31:109–113. [PubMed]
118. Griefahn B., Kunemund C., Blaszkewicz M., Golka K., Mehnert P., Degen G. Experiments on the effects of a continuous 16.7 Hz magnetic field on melatonin secretion, core body temperature, and heart rates in humans. Bioelectromagnetics. 2001;22:581–588. [PubMed]
119. Haugsdal B., Tynes T., Rotnes JS., Griffiths D. A single nocturnal exposure to 2-7 millitesla static magnetic fields does not inhibit the excretion of 6sulfatoxymelatonin in healthy young men. Bioelectromagnetics. 2001;22:1–6. [PubMed]
120. Hong SC., Kurokawa Y., Kabuto M., Ohtsuka R. Chronic exposure to ELF magnetic fields during night sleep with electric sheet: effects on diurnal melatonin rhythms in men. Bioelectromagnetics. 2001;22:138–143. [PubMed]
121. Levallois P., Dumont M., Touitou Y., et al. Effects of electric and magnetic fields from high-power lines on female urinary excretion of 6-sulfatoxymelatonin. Am J Epidemiol. 2001;154:601–609. [PubMed]
122. Griefahn B., Kunemund C., Blaszkewicz M., Golka K., Degen G. Experiments on effects of an intermittent 16.7-Hz magnetic field on salivary melatonin concentrations, rectal temperature, and heart rate in humans. IntArch Occup Environ Health. 2002;75:171–178. [PubMed]
123. Youngstedt SD., Kripke DF., Elliott JA., Assmus JD. No association of 6sulfatoxymelatonin with in-bed 60-Hz magnetic field exposure or illumination level among older adults. Environ Res. 2002;89:201–209. [PubMed]
124. Kurokawa Y., Nitta H., Imai H., Kabuto M. Acute exposure to 50 Hz magnetic fields with harmonics and transient components: lack of effects on nighttime hormonal secretion in men. Bioelectromagnetics. 2003;24:12–20. [PubMed]
125. Touitou Y., Lambrozo J., Camus F., Charbuy H. Magnetic fields and the melatonin hypothesis: a study of workers chronically exposed to 50-Hz magnetic fields. Am J Physiol Regul Integr Cornp Physiol. 2003;284:R1529–R535. [PubMed]
126. arman GR., Tripp H., Warman VL., Arendt J. Acute exposure to circularly polarized 50-Hz magnetic fields of 200-300 microT does not affect the pattern of melatonin secretion in young men. J Clin Endocrinol Metab. 2003;88:5668–5673. [PubMed]
127. Cocco P., Cocco ME., Paghi L., et al. Urinary 6-sulfatoxymelatonin excretion in humans during domestic exposure to 50 hertz electromagnetic fields. Neuro Endocrinol Lett. 2005;26:136–142. [PubMed]
128. Gobba F., Bravo G., Scaringi M., Roccatto L. No association between occupational exposure to ELF magnetic field and urinary 6-sulfatoximelatonin in workers. Bioelectromagnetics. 2006;27:667–673. [PubMed]
129. Juutilainen J., Kumlin T. Occupational magnetic field exposure and melatonin: interaction with light-at-night. Bioelectromagnetics. 2006;27:423–426. [PubMed]
130. Clark ML., Burch JB., Yost MG., et al. Biomonitoring of estrogen and melatonin metabolites among women residing near radio and television broadcasting transmitters. J Occup Environ Med. 2007;49:1149–1156. [PubMed]
131. Free MJ., Kaune WT., Phillips RD., Cheng HC. Endocrinological effects of strong 60-Hz electric fields on rats. Bioelectromagnetics. 1981;2:105–121. [PubMed]
132. Quinlan WJ., Petrondas D., Lebda N., Pettit S., Michaelson SM. Neuroendocrine parameters in the rat exposed to 60-Hz electric fields. Bioelectromagnetics. 1985;6:381–389. [PubMed]
133. Portet R., Cabanes J. Development of young rats and rabbits exposed to a strong electric field. Bioelectromagnetics. 1988;9:95–104. [PubMed]
134. Thompson JM., Stormshak F., LeeJM Jr., Hess DL., Painter L. Cortisol secretion and growth in ewe lambs chronically exposed to electric and magnetic fields of a 60-Hertz 500-kilovolt AC transmission line. J Anim Sci. 1995;73:3274–3280. [PubMed]
135. Burchard JF., Nguyen DH., Richard L., Block E. Biological effects of electric and magnetic fields on productivity of dairy cows. J Dairy Sci. 1996;79:1549–1554. [PubMed]
136. Szemerszky R., Zelena D., Barna I., Bardos G. Stress-related endocrinological and psychopathological effects of short- and long-term 50Hz electromagnetic field exposure in rats. Brain Res Bull. 2010;81:92–99. [PubMed]
137. Martinez-Samano J., Torres-Duran PV., Juarez-Oropeza MA., VerdugoDiaz L. Effect of acute extremely low frequency electromagnetic field exposure on the antioxidant status and lipid levels in rat brain. Arch Med Res. 2012. Epub ahead of print. 2012.04.003. [PubMed]
138. Hackman RM., Graves HB. Corticosterone levels in mice exposed to highintensity electric fields. Behav Neural Biol. 1981;32:201–213. [PubMed]
139. Gorczynska E., Wegrzynowicz R. Glucose homeostasis in rats exposed to magnetic fields. Invest Radiol. 1991;26:1095–1100. [PubMed]
140. Gorczynska E., Wegrzynowicz R. Structural and functional changes in organelles of liver cells in rats exposed to magnetic fields. Environ Res. 1991;55:188–198. [PubMed]
141. de Bruyn L., de Jager L. Electric field exposure and evidence of stress in mice. Environ Res. 1994;65:149–160. [PubMed]
142. Picazo ML., Miguel MP., Romo MA., Varela L., Franco P., Gianonatti C., Bardasano JL. Changes in mouse adrenalin gland functionality under second-generation chronic exposure to ELF magnetic fields. I. males. Electro Magnetobiol. 1996;15:85–98.
143. Marino AA., Wolcott RM., Chervenak R., et al. Coincident nonlinear changes in the endocrine and immune systems due to low-frequency magnetic fields. Neuroimmunomodulation. 2001;9:65–77. [PubMed]
144. Mostafa RM., Mostafa YM., Ennaceur A. Effects of exposure to extremely low-frequency magnetic field of 2 G intensity on memory and corticosterone level in rats. Physiol Behav. 2002;76:589–595. [PubMed]
145. Bonhomme-Faivre L., Mace A., Bezie Y., et al. Alterations of biological parameters in mice chronically exposed to low-frequency (50 Hz) electromagnetic fields. Life Sci. 1998;62:1271–1280. [PubMed]
146. Maresh CM., Cook MR., Cohen HD., Graham C., Gunn WS. Exercise testing in the evaluation of human responses to powerline frequency fields. Aviat Space Environ Med. 1988;59:1139–1145. [PubMed]
147. Gamberale F., Olson BA., Eneroth P., Lindh T., Wennberg A. Acute effects of ELF electromagnetic fields: a field study of linesmen working with 400 kV power lines. BrJIndMed. 1989;46:729–737. [PMC free article] [PubMed]
148. Selmaoui B., Lambrozo J., Touitou Y. Endocrine functions in young men exposed for one night to a 50-Hz magnetic field. A circadian study of pituitary, thyroid and adrenocortical hormones. Life Sci. 1997;61:473–486. [PubMed]
149. Ghione S., Del Seppia C., Mezzasalma L., Emdin M., Luschi P. Human head exposure to a 37 Hz electromagnetic field: effects on blood pressure, somatosensory perception, and related parameters. Bioelectromagnetics. 2004;25:167–175. [PubMed]
150. Blankenburg M., Haberland L., Elvers HD., Tannert C., Jandrig B. Highthroughput omics technologies: potential tools for the investigation of influences of EMF on biological systems. Curr Genomics. 2009;10:86–92. [PMC free article] [PubMed]
151. Girgert R., Grundker C., Emons G., VHant V. Electromagnetic fields alter the expression of estrogen receptor cofactors in breast cancer cells. Bioelectromagnetics. 2008;29:169–176. [PubMed]
152. Wilson BW., Matt KS., Morris JE., Sasser LB., Miller DL., Anderson LE. Effects of 60 Hz magnetic field exposure on the pineal and hypothalamicpituitary-gonadal axis in the Siberian hamster (Phodopus sungorus). Bioelectromagnetics. 1999;20:224–232. [PubMed]

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