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Logo of neurodistDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressNeuropsychiatric Disease and Treatment
Neuropsychiatr Dis Treat. 2013; 9: 139–142.
Published online 2013 January 17. doi:  10.2147/NDT.S39077
PMCID: PMC3552547

Capgras-like syndrome in a patient with an acute urinary tract infection


Delusional misidentification syndromes are a group of delusional phenomena in which patients misidentify familiar persons, objects, or themselves, believing that they have been replaced or transformed. In 25%–40% of cases, misidentification syndromes have been reported in association with organic illness. We report an acute episode of Capgras-like delusion lasting 8 days, focused on the idea that people were robots with human bodies, in association with an acute urinary infection. To our knowledge, this is the first case report associating urinary tract infection with Capgras-like syndrome. Awareness of the prevalence of delusional misidentification syndromes associated with acute medical illness should promote diligence on the part of clinicians in recognizing this disorder.

Keywords: delusional misidentification, Capgras syndrome, urinary tract infection, psychosis


Delusional misidentification syndromes are a group of delusional phenomena in which patients misidentify familiar persons, objects, or themselves, believing that they have been replaced or transformed. These syndromes can be considered delusional because the misidentifications are false and are not correctable by experience or reason.1

The most common form of misidentification is the Capgras syndrome. Originally described by Capgras and Reboul-Lachaux,2,3 this disorder consists of the delusional belief that a person or persons have been replaced by “doubles” or impostors. Following 19th century reports in Germany by Kahlbaum,4 Capgras and Reboul-Lachaux described “Mme M”, who displayed a florid set of psychotic symptoms, including the belief that her husband, children, neighbors, and others had been replaced by doubles. The doubles themselves were replaced by other doubles (80 times in the case of her husband). However, patients with the delusion usually report that people emotionally close to them have been substituted. Often they hold this belief with frightening conviction, even being prepared to kill the “impostor”.5 Cases have also been described where the delusion is that pets6,7 or even inanimate objects8 have been replaced by replicas.9

A recent well publicized UK court case of Capgras delusion involved a teacher named Alan Davies who, following a car crash, developed the belief that his wife had died in the accident and that the woman living with him was an impostor, and someone with whom he had become uncomfortable. He still insists that his real wife died in the accident, and he successfully sued the driver of the other vehicle for the distress caused. In court, a consultant psychiatrist explained that Mr Davies was suffering from Capgras delusion.9,10

Another type of misidentification is the Fregoli syndrome,11 in which there is the belief that a person who is well known to the patient is actually pretending to take on the appearance of a relative stranger whom the patient encounters. Vie characterized Capgras syndrome as the illusion of negative doubles and Fregoli syndrome as the illusion of positive doubles.12

Other misidentification syndromes are the syndrome of intermetamorphosis, characterized by the belief that another person has changed both his physical and psychological identities (ie, has been transformed into another) and the syndrome of subjective doubles, characterized by the belief that another person has been physically transformed into the patient’s own self.1

Misidentification syndromes are more frequent in females (75%). The age of onset varies from 12 to 78 years, with an average in the early 40s.13 In more than four of five patients, the onset is after the age of 30 years.14 Capgras delusion occurs in a variety of settings as a symptom of idiopathic psychiatric illness, eg, schizophrenia or mood disorders, and in 25%–40% of cases misidentification syndromes have been reported in association with organic illnesses, including cerebrovascular disease, post-traumatic encephalopathy, temporal lobe epilepsy, post-encephalitic parkinsonism, infections, viral encephalitis, migraine, vitamin B12 defciency, hepatic encephalopathy, hypothyroidism, pseudoparathyroidism, and dementia.15

Some studies have found correlations between the psychopathological symptoms of Capgras syndrome (in particular, misidentification and alterations of memory, feeling of familiarity, monitoring of self, and reality) and neurobiological alterations and damage to the right temporal lobe, and the limbic and bifrontal regions.16,17 Other studies, in which functional magnetic resonance imaging was used, emphasize the importance of the superior temporal sulcus in face recognition and perception, and show that alteration of this specific area could compromise these functions.18 Ellis and Young have also suggested that, despite their obvious differences, there might be a link between prosopagnosia (complete inability to recognize previously familiar faces) and Capgras delusion, positing the idea that the two conditions might be mirror images of one another.19 Here we describe the case of a young patient with an acute episode of Capgras syndrome lasting for 8 days in association with an acute urinary tract infection.

Case report

Mr J was an 18-year-old academically gifted South American student who was visiting Italy as a tourist. He had normal neuropsychological development during infancy. He was travelling around Europe during his holidays to celebrate the end of high school. He was an easy-going person, having had many relationships but without a significant long-term partner. He had several hobbies (football, technologies, cars) and planned to start his university studies in international politics. He had not experienced any previous psychopathological problems. He did not drink alcohol or caffeine, and did not use any illicit or recreational drugs. His great-grandmother had suffered from schizophrenia.

The patient was admitted to the psychiatric ward of Policlinico Umberto I Hospital, Sapienza University of Rome, appearing to be deeply distressed, dysphoric, and confused, with disorganized speech and thoughts. He presented with persecutory and transformation delusions focused on the idea that every person was a robot with a human body. He had disorganized auditory hallucinations, hearing voices of relatives (mother, father, cousins) telling him to escape from the hospital because there were robots there who wanted to kill him. He did not recognize his cousin (thinking that the cousin was a robot with the body and face of his cousin). A toxicology screen was negative for psychoactive substances.

Computed tomography of the head without contrast did not show any hemorrhagic intraparenchymal or extra-parenchymal lesions or alterations in parenchymal density, either over and under the cerebellar tentorium, and showed normal flow in the ventricular system and cerebral spinal fluid spaces. Blood laboratory investigations were normal, with the exception of white blood cells at 11,650 per μL and neutrophils at 7950 per μL.

On admission, the patient was started on clonazepam 5 mg/day to treat his agitation, risperidone 4 mg/day to treat his psychotic symptoms, and valproate 750 mg/day to treat his dysphoric mood.

On day 3, the patient presented again with fever (38.5°C) and a worsening of his delusional symptoms. His hallucinations had worsened in intensity and frequency. He was distressed, presenting with psychomotor agitation and disorganized behavior, and tried to escape from the ward. Blood tests were again normal, with the exception of white blood cells at 16,790 per μL, neutrophils at 14,440 per μL (86%), and lymphocytes of 7.4%. Microscopic examination of the urinary sediment showed many white blood cells, red blood cells, and bacteria. Urine culture was positive for Proteus mirabilis (>100,000 colony-forming units) and Enterococcus spp (<1000 colony-forming units). Treatment with ciprofoxacin was started at 1000 mg/day. The fever disappeared on day 7, and his psychopathological condition improved. Laboratory blood investigations also improved, with a normal white cell count of 6.330 per μL, neutrophils at 3680 per μL (58.2%) and lymphocytes at 25.4%. By day 8, the delusional and hallucination symptoms had disappeared, the patient was cooperative and well orientated in time and space, and he presented with euthymic mood and normal psychomotor skills. He remembered the hallucinations and delusions as if they had been a dream he had had whilst awake, with qualitative alteration of consciousness. On the same day, because of full remission of symptoms, the patient was discharged from hospital and returned to Brazil accompanied by relatives.


Capgras delusions are typically focused on a small number of people or just one person. These people are typically emotionally close to the deluded person; atypically, Mr J believed that every person was a robot, even people he did not know very well, including doctors and nurses. Because of this particular clinical feature, we would define his psychopathological condition as Capgras-like syndrome. The clinical report presented here clearly suggests a correlation between an acute infection and delusional symptoms, and to our knowledge, this is the first case report of an association between urinary tract infection and Capgras-like syndrome.

Several psychopathological areas are usually impaired in Capgras syndrome and in this case impaired consciousness, thoughts, memory, perception, and allo psychic derealization were involved. We can argue that such a complex symptomatology could indicate diffuse functional damage of the brain. For this reason, it is possible to hypothesize that the frequent association between organic disease and misidentification delusions is linked to wider neuronal interconnectivity (hodological) problems rather than to specific topological problems.

Even if delusional misidentifications are known to be potentially correlated with infectious conditions, few relevant papers are available in the scientific literature. Crichton and Lewis reported on a patient with acquired immune deficiency syndrome who developed Capgras syndrome as part of an acute confusional state resulting from an opportunistic infection.20 In 1991, Förstl et al reviewed 260 case reports of misidentification syndromes,21 and identified two cases in association with pneumonia, one case in association with tuberculosis, one case in association with acquired immune deficiency syndrome, and one case in association with neurocysticercosis.

It is also true that several other infective conditions may exacerbate or lead to different kinds of acute psychosis. Infections caused by Epstein–Barr virus,22 Borrelia,23 human immunodeficiency virus,24Mycoplasma pneumoniae,25Coxiella Burnetii,26 toxoplasmosis,27 herpes simplex,28 and Salmonella typhi29 have been reported as possible causes of acute psychosis.

In cases of infective diseases with secondary sepsis, there may be two different pathological mechanisms related to brain injury. On the one hand, we could have an injury related to the inflammatory system, including proinflammatory cytokines, and in particular tumor necrosis factor alpha. This mediator could involve direct cellular damage to the brain, mitochondrial and endothelial dysfunction, and disturbances in neurotransmission.30 On the other hand, we may have a direct interaction between the proinflammatory system and cholinergic transmission that produces confusion directly.31 Environmental agents, such as stress or bacteria, are unlikely to be sufficient to induce a delusional syndrome; in the case of Mr J, a vulnerability to psychosis was identified in the family history, ie, his great-grandmother being affected by schizophrenia.

An interesting feature of this case is the theme of robots. To date, only one paper has reported robots or androids as possible misidentifications occurring in Capgras syndrome.9 This may be related to the fact that only in the last few years has the presence of robots with human features become culturally and internationally relevant (for example with the “Blade Runner” film and the books written by Isaac Asimov). It is possible that the contents of misidentification delusions are changing (humans become androids) concomitantly with general cultural issues of the day, and that other terms should probably be used to describe this emerging psychopathological syndrome, eg, “android syndrome”.

It is often difficult to distinguish between psychosis due to organic conditions and psychosis heralding the onset of a chronic psychotic illness, in particular when there is a positive family history of schizophrenia (as in the case of Mr J) and when different kind of medications are given concomitantly, like the antipsychotics and antibiotics in the present case.

In the future, it would be extremely valuable to perform functional magnetic resonance imaging to investigate delusional misidentification syndromes further. Awareness of the prevalence of delusional misidentification syndromes associated with acute medical illness should promote diligence on the part of clinicians in recognizing this disorder. Organic disease should be ruled out before a diagnosis of a mental or cognitive disorder is made.



The authors report no conflicts of interest in this work.


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