This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Doxorubicin decreases AQP2 in inner medulla (IM) and Erlotinib restores levels in IM tip.
Shown: AQP2 protein abundance in IM tip and base tissue of control rats (Ctrl; white bars), doxorubicin treated rats (Dox; solid black bars), and doxorubicin + Erlotinib treated rats (Dox + Erl; patterned bars). A: Representative immunoblots showing abundance of AQP2 in IM tip and base tissue lysates. Each lane containes samples from a different rat. B: Densitometric analysis of western blots from 3 cohorts of animals. Data were normalized for the average densitometry of untreated animals in each group. Data are expressed as means ± SE (n=11, * p<0.05).