Our analysis demonstrates that up to one third of pediatric patients receiving CPD in pediatric centers around the globe have at least 1 co-existing nonrenal comorbidity and that many have multiple comorbidities. The presence of comorbidities appears to be associated with a higher hospitalization rate and a lower patient survival rate. Additional data collection and analyses should more clearly define the impact of comorbidities compared with those of modifiable clinical parameters (including dialysis adequacy and hemoglobin, fluid, and blood pressure control) on outcomes in this complex patient population.
The following principal investigators are contributing to the IPPN registry:
Argentina: L. Alconcher, Hospital Interzonal General, Bahia Blanca; E. Sojo, Hospital de Pediatria Garrahan, Buenos Aires; P.A. Coccia, Hospital Italiano de Buenos Aires; A. Suarez, Hospital de Niños Sor Maria Ludovica, La Plata; P.G. Valles, Hospital Pediatrico Humberto Notti, Mendoza; R. Salim, Rennius SA Salta. Belgium: K. van Hoeck, University Hospital Antwerp, Edegem. Brazil: V. Koch, Hospital das Clinicas FMUSP, Sao Paulo. Canada: J. Feber, Children’s Hospital of Eastern Ontario, Ottawa; D.A. Geary, Hospital for Sick Children, Toronto; C. White, BC Children’s Hospital, Vancouver. Chile: M. Valenzuela, Hospital Guillermo Grant Benavente, Concepcion; J. Villagra, Hospital Base, Osorno; F. Cano, Hospital Luis Calvo Mackenna, Santiago; M.A. Contreras, Roberto del Rio Hospital, Santiago; A. Vogel, Pontivicia Universidad Catolica de Chile, Santiago; P. Zambrano, Hospital Dr. Gonzales Cortes, Santiago; P. Berrocal, Hospital Sotero del Rio, Santiago. PR China: Kei-Chiu Tse, Princess Margret Hospital, Hong Kong; H. Xu, Children’s Hospital of Fudan University, Shanghai. Czech Republic: K. Vondrak, University Hospital Motol, Prague. Finland: K. Rönnholm, Hospital for Children and Adolescents, Helsinki. France: J. Harambat, Hôpital des Enfants, Bordeaux; B. Ranchin, Hôpital Femme Mère Enfant, Lyon; G. Roussey, CHU Nantes; T. Ulinski, Armand Trousseau Hospital, Paris; M. Fischbach, Children’s Dialysis Center, Strasbourg. Germany: R. Büscher, Children’s Hospital Essen; M. Kemper, University Medical Center, Hamburg; L. Pape, Medical School, Hannover; F. Schaefer and D. Borzych, Center for Pediatrics and Adolescent Medicine, Heidelberg; J. Misselwitz, Kidney Center for Children and Adolescents; G. Klaus, University Hospital, Marburg; D. Haffner, University Children’s Hospital, Rostock. Greece: F. Papachristou, Aristoteles University, Thessaloniki. Hungary: A. Szabo, 1st Department of Pediatrics, Semmelweis University, Budapest. India: A. Bagga, All India Institute of Medical Sciences, New Delhi; M. Kanitkar, Armed Forces Medical College, Pune. Italy: E. Verrina, G. Gaslini Institute, Genova; A. Edefonti, Fondazione Ospedale Maggiore Policlinico, Milano; E. Vidal, Pediatric Nephrology, Dialysis and Transplant Unit, Padova; G. Leozappa, Dipartimento Nefrologia-Urologia, Rome. Israel: D. Landau, Soroka Medical Center, Beer-Sheva. Korea: I.S. Ha, Dialysis Center for Children and Adolescents, Seoul; K.H. Paik, Samsung Medical Center, Seoul. Lebanon: B. Aoun, Rafik Hariri University Hospital, Beirut. Macedonia: E. Sahpazova, Pediatric Clinic, Skopje. Mexico: L. Sànchez Barbosa, Pediatric Hospital Medical Center SXXI, Cuahutemoc. New Zealand: W. Wong, Starship Children’s Hospital, Auckland. Netherlands: J.W. Groothoff, Academic Medical Center, Amsterdam. Nicaragua: Y. Silva, Hospital Infantil de Nicaragua, Managua. Peru: R. Loza Munarriz, Cayetano Heredia Hospital, Lima, Peru. Poland: A.M. Zurowska and D. Borzych, Medical University, Gdańsk; D. Drozdz, University Children’s Hospital, Krakow; M. Lipka, Children’s Memorial Health Institute, Warsaw; H. Ziolkowska, Public Paediatric Teaching Hospital, Warsaw; M. Sczepanska, Dialysis Division for Children, Zabrze. Romania: O. Brumariu, St. Maria Children’s Hospital, Iasi. Saudi Arabia: J. Kari, King AbdulAziz University Hospital, Jeddah. Singapore: H.K. Yap, Shaw-NKF-NUH Children’s Kidney Center. Spain: G. Ariceta, Hospital de Cruces, Baracaldo; F. Santos, Hospital Universitario Central de Asturias, Oviedo. Turkey: N. Besbas, Hacettepe University, Ankara; S. Bakkaloglu, Gazi University, Ankara; I. Bilge, Department of Pediatric Nephrology, Çapa-Istanbul; E. Serdaroglu, Dr. Behcet Children Research and Educational Hospital, Izmir; A. Bal, Tepecik Children and Research Hospital, Izmir; S. Mir, Ege University Faculty of Medicine, Izmir-Bornova. United Kingdom: L. Rees, Great Ormond Street Hospital, London; A.R. Watson, Children and Young People’s Kidney Unit, Nottingham. Uruguay: J. Grünberg, SE.N.NI.AD, Montevideo. United Arab Emirates: E. Simkova, Dubai Hospital. United States: L. Greenbaum, Children’s Healthcare Pediatric Dialysis Unit, Atlanta; A. Neu, Johns Hopkins Hospital, Baltimore; D. Askenazi, Children’s Hospital of Alabama, Birmingham; M. Ferris, University of North Carolina, Chapel Hill; H. Patel, Children’s Hospital, Columbus; S. Al-Akash, Driscoll Children’s Hospital, Corpus Christi; S. Pottoore, Children’s Medical Center, Dallas; V. Dharnidharka, Division of Pediatric Nephrology, Gainesville; T. Bunchman, Helen DeVos Children’s Hospital, Grand Rapids; A. Chua, Texas Children’s Hospital, Houston; B.A. Warady, Children’s Mercy Hospital, Kansas City; N. McAfee, Seattle Children’s Hospital; J. Zaritsky, UCLA Medical Center, Los Angeles.