Search tips
Search criteria 


Logo of iaiPermissionsJournals.ASM.orgJournalIAI ArticleJournal InfoAuthorsReviewers
Infect Immun. 1981 January; 31(1): 334–338.
PMCID: PMC351787

Propagation of Korean hemorrhagic fever virus in laboratory rats.


Korean hemorrhagic fever virus (KHFV) has been adapted to the Wistar and Fisher strains of rats. Infection was detected by the appearance of specific antigen in the lung tissue of the infected rats at 14 to 64 days after inoculation and by the appearance of circulating antibodies in ther serum which reacted specifically with KHFV antigen in the lungs of infected Apodemus agrarius subsp. coreae 3 weeks after inoculation. Distribution of antigen in rat tissues as determined by immunofluorescent staining was the same as that in Apodemus mice except that antigen was present in the spleens of rats. Adaptation of KHFV to the laboratory rat provides an animal model that is free of wild rodent viruses and is readily available for use in studies on the characterization of KHFV.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (713K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Brummer-Korvenkontio M, Vaheri A, Hovi T, von Bonsdorff CH, Vuorimies J, Manni T, Penttinen K, Oker-Blom N, Lähdevirta J. Nephropathia epidemica: detection of antigen in bank voles and serologic diagnosis of human infection. J Infect Dis. 1980 Feb;141(2):131–134. [PubMed]
  • CH'IU FH, HOU TC, HUANG PS, LIU WC, SUNG HY, LI Y. Epidemic hemorrhagic fever; investigations in T'uliho area, Inner Mongolia, and clinical study of 104 cases. Chin Med J. 1959 Jun;78:515–531. [PubMed]
  • GAJDUSEK DC. Virus hemorrhagic fevers. Special reference to hemorrhagic fever with renal syndrome (epidemic hemorrhagic fever). J Pediatr. 1962 Jun;60:841–857. [PubMed]
  • Lee HW, Lee PW, Johnson KM. Isolation of the etiologic agent of Korean Hemorrhagic fever. J Infect Dis. 1978 Mar;137(3):298–308. [PubMed]
  • Lee HW, Lee PW, Lähdevirta J, Brummer-Korventkontio M. Aetiological relation between Korean haemorrhagic fever and nephropathia epidemica. Lancet. 1979 Jan 27;1(8109):186–187. [PubMed]
  • Lee PW, Gajdusek DC, Gibbs CJ, Xu ZY. Aetiological relation between Korean haemorrhagic fever with renal syndrome in People's Republic of China. Lancet. 1980 Apr 12;1(8172):819–820. [PubMed]
  • Lee PW, Gibbs CJ, Jr, Gajdusek DC, Hsiang CM, Hsiung GD. Identification of epidemic haemorrhagic fever with renal syndrome in China with Korean haemorrhagic fever. Lancet. 1980 May 10;1(8176):1025–1026. [PubMed]
  • Manasia M, Olinic N, Zăgreanu I, Serban A. Hemorrhagic fever with renal syndrome: report of 11 observations. Int Urol Nephrol. 1977;9(2):177–184. [PubMed]
  • PLANK J, REZUCHA M, ROJKOVIC D. Prvé dva diagnostikované prípady hemoragickej nefrózo nefritídy na území nasej republiky; vírová nefrózo-nefritída Dalekeho východu. Cas Lek Cesk. 1955 Sep 30;94(40):1078–1084. [PubMed]
  • SHEEDY JA, FROEB HF, BATSON HA, CONLEY CC, MURPHY JP, HUNTER RB, CUGELL DW, GILES RB, BERSHADSKY SC, VESTER JW, et al. The clinical course of epidemic hemorrhagic fever. Am J Med. 1954 May;16(5):619–628. [PubMed]
  • SMADEL JE. Epidemic hemorrhagic fever. Am J Public Health Nations Health. 1953 Oct;43(10):1327–1330. [PubMed]
  • Svedmyr A, Lee HW, Berglund A, Hoorn B, Nyström K, Gajdusek DC. Epidemic nephropathy in Scandinavia is related to Korean haemorrhagic fever. Lancet. 1979 Jan;1(8107):100–100. [PubMed]
  • Svedmyr A, Lee PW, Gajdusek DC, Gibbs CJ, Jr, Nyström K. Antigenic differentiation of the viruses causing Korean haemorrhagic fever and epidemic (endemic) nephropathy of Scandinavia. Lancet. 1980 Aug 9;2(8189):315–316. [PubMed]
  • Umenai T, Lee HW, Lee PW, Saito T, Toyoda T, Hongo M, Yoshinaga K, Nobunaga T, Horiuchi T, Ishida N. Korean haemorrhagic fever in staff in an animal laboratory. Lancet. 1979 Jun 23;1(8130):1314–1316. [PubMed]
  • Vesenjak-Hirjan J, Hrabar A, Vince-Ribarić V, Borcić B, Brudnjak Z. An outbreak of hemorrhagic fever with a renal syndrome in the Plitvice Lakes area (preliminary report). Folia Parasitol (Praha) 1971;18(3):275–279. [PubMed]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)