Control of alternative pre-mRNA splicing by Ca++ signals

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Biochim Biophys Acta. 2008 August; 1779(8): 438–452.

Published online 2008 January 17. doi: 10.1016/j.bbagrm.2008.01.003

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Table 3

List of RNA binding proteins/splicing factors regulated by Ca⁺⁺ signals

Splicing factor	Ca⁺⁺ signal-inducer/inhibitor/partner	Splicing factor change/interaction	Earliest time splicing change detected	Cell/extract	Reference
CPSF30	CaM	Inhibited RNA binding activity	NA	A. thaliana	Delaney et al. [192]
hnRNP A1	Depolarization	Increased nuclear protein level	12 h	Cortical culture	An and Grabowski [84]
hnRNP A2	CaM	Binds CaM column, inhibited phosphorylation by Casein kinase 2, colocalization with CaM in nucleus	NA	Rat liver	Bosser et al. [190]
hnRNP C	CaM	Binds CaM column, inhibited phosphorylation by Casein kinase 2, colocalization with CaM in nucleus	NA	Rat liver	Bosser et al. [190]
hnRNP H3	Depolarization	Repressed exon inclusion	24 h	Cortical culture	An and Grabowski [84]
PP2A	CaMK IV	Dephosphorylated Thr196 of CaMK IV and inhibited gene transcription	NA	In vitro	Tokumitsu et al. [185], Anderson et al. [187]
RNPS1	Depolarization	Repressed exon inclusion	6 h	Cortical culture	An and Grabowski [84]
SAP145	CaM	Binds CaM column	NA	NA	Agell et al. [191]
Tra2 beta1	Thapsigargin	Cytoplasmic accumulation	1 h	Cortical culture	Daoud et al. [106]

The list is according to the protein name/description in alphabetical order. NA: not available.