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Biochim Biophys Acta. Author manuscript; available in PMC 2012 November 16.
Published in final edited form as:
Biochim Biophys Acta. 2008 August; 1779(8): 438–452.
Published online 2008 January 17. doi: 10.1016/j.bbagrm.2008.01.003

Fig. 1

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Diagram of Ca++ signal-regulation of alternative splicing. Shown in the middle is a cassette exon (e2) with two flanking introns (a and b) and constitutive exons (e1 and e3), with exonic and intronic cis-acting pre-mRNA elements as splicing enhancers (green, +) or silencers (red, −) and trans-acting splicing factors (ovals) indicated. Without signal stimulation (above), the pre-mRNA is spliced in two pathways (I and II) with a given ratio leading to the inclusion (I) or exclusion (II) of the alternative exon e2 and the respective lariats. With signal induction, like Ca++ (below), one pathway (here for example, II, heavier arrows) over the other pathway (I) is favored in a particular cell to promote the production of one variant mRNA. Through this regulation, Ca++ signals will change the relative ratio of the variant mRNA or protein isoforms of different properties. (?: mostly unknown intermediate steps).

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