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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
 
From:
Nat Immunol. Author manuscript; available in PMC 2013 June 1.
Published in final edited form as:
Nat Immunol. 2012 April 29; 13(6): 587–595.
doi: 10.1038/ni.2286

Figure 6

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miR-10a constrains TH17 differentiation in the presence of RA. (a) Naïve CD4+ T cells were transduced with a retroviral construct expressing a miR-10a-5p “sponge” target sequence (miR10a-5pT) or a scrambled sequence (control) and cultured under TH17 conditions with anti-IL-2 antibody and ATRA (1.5 nM). (b, c) Naïve CD4+ T cells were transduced with a retroviral construct expressing miR-10a or control vector under TH17 conditions and anti-IL-2 with (b) or without ATRA (1.5 nM) (c). Cells were analyzed for Foxp3 and IL-17A expressions by flow cytometry. A representative experiment is depicted in the left panel and pooled data from multiple independent experiments are shown in the right panels. Statistical significance was determined by paired sample t-test.

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