The results suggest a similar outcomes to previous data.The documented difference between two groups, in intestinal growth and proliferation, was attributed at a certain extent on the triggering of the increased decelerated nutrient load [1
]. In several previous studies endogenous insulin and growth hormone have been reported as potent stimulants in intestinal turnover and potentially beneficial factors in the treatment of short bowel syndrome as part of their main anabolic and general regulatory action to overall body metabolic rate and weight balance [7
]. Actions of GH mediated by Insulin Growth Factor 1 stimulation, resulting in trophic effects in intestinal mucosa in addition with enhancement of intracellular transportation of nutrient constituents [1
]. Similarly insulin is known to be involved in modulation of growth and differentiation of small bowel [5
The lacks of substantial differences in both factors’ levels appear mainly to reflect the lack of significant weight gain after the interposition in our experimental setting. It may thus be postulated that the histopathologically demonstrated enhanced intestinal adaptation after the interposition [6
] and the nutritional status represent two distinct variables which do not obligatorily correlate with each other.
In parallel with the above it is well known that main source of production of both hormones is other than small bowel and secretion is subject to different stimuli and multifarious regulation systems.
Indeed, in agreement with the present findings, serum albumin had not exhibited significant changes [6
Given these findings on endogenous hormones, the future experimental studies should focus on the effect of exogenously administered growth hormone or insulin upon intestinal adaptation after the interposition of a reversed jejunal segment.