Search tips
Search criteria 


Logo of bmcpsycBioMed Centralsearchsubmit a manuscriptregisterthis articleBMC Psychiatry
BMC Psychiatry. 2012; 12: 104.
Published online Aug 7, 2012. doi:  10.1186/1471-244X-12-104
PMCID: PMC3492014
Structural brain changes in first episode Schizophrenia compared with Fronto-Temporal Lobar Degeneration: a meta-analysis
Bayanne Olabi,corresponding author1 Ian Ellison-Wright,2 Ed Bullmore,3,4 and Stephen M Lawrie1
1Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, EH10 5HF, UK
2Avon and Wiltshire Mental Health Partnership NHS Trust, Salisbury, UK
3Department of Psychiatry, Behavioral & Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
4Cambridgeshire & Peterborough NHS Foundation Trust, Cambridge, UK
corresponding authorCorresponding author.
Bayanne Olabi: b.olabi/at/; Ian Ellison-Wright: ian.ew/at/; Ed Bullmore: etb23/at/; Stephen M Lawrie: s.lawrie/at/
Received December 29, 2011; Accepted July 31, 2012.
The authors sought to compare gray matter changes in First Episode Schizophrenia (FES) compared with Fronto-Temporal Lobar Degeneration (FTLD) using meta-analytic methods applied to neuro-imaging studies.
A systematic search was conducted for published, structural voxel-based morphometric MRI studies in patients with FES or FTLD. Data were combined using anatomical likelihood estimation (ALE) to determine the extent of gray matter decreases and analysed to ascertain the degree of overlap in the spatial distribution of brain changes in both diseases.
Data were extracted from 18 FES studies (including a total of 555 patients and 621 comparison subjects) and 20 studies of FTLD or related disorders (including a total of 311 patients and 431 comparison subjects). The similarity in spatial overlap of brain changes in the two disorders was significant (p = 0.001). Gray matter deficits common to both disorders included bilateral caudate, left insula and bilateral uncus regions.
There is a significant overlap in the distribution of structural brain changes in First Episode Schizophrenia and Fronto-Temporal Lobar Degeneration. This may reflect overlapping aetiologies, or a common vulnerability of these regions to the distinct aetio-pathological processes in the two disorders.
Keywords: Schizophrenia/pathology, FTLD/pathology, Meta-analysis, Magnetic resonance imaging/methods, Humans, Brain/pathology, Brain mapping, Imaging processing, Computer-Assisted/methods
Articles from BMC Psychiatry are provided here courtesy of
BioMed Central