The final sample of 1308 children was comparable to the sample of Dutch children (n
1598 out of n
2452) who underwent a finger prick, in terms of maternal educational level (p
0.13), income adequacy (p
0.97), and BMI (15.4 vs 15.3 p
0.35). However these children were slightly younger (5.6 vs 5.7, p
0.004). Children with available markers of lipid and glucose metabolism tended to have higher educated mothers (9.9 vs 8.2
years of education after primary school), older mothers (32.1 vs 30.2 y), mothers with a lower body mass index (23.0 vs 23.2), and higher birth weight (3503 vs 3360
g) compared to the initial ABCD-cohort.
As presented in Table
, the children’s mean age in the current sample was 5.67 (SD 0.43). Maternal pre pregnancy BMI, duration of breastfeeding, childhood BMI, and duration of walking to school differed between educational groups.
Concentrations of cholesterol, HDL, LDL, and triglycerides were equal between educational groups. However, there were educational inequalities in fasting glucose, C-peptide, and insulin resistance with higher values in children of less educated mothers (Table
). In univariate analyses (Table
), cholesterol, LDL, and triglycerides were associated with sex, with higher levels in girls. In addition, cholesterol and HDL were associated with age, and size at birth. Glucose, C-peptide, and insulin resistance were associated with age and childhood BMI. Moreover, glucose and C-peptide were associated with sex, and height. As sports club membership and size at birth were borderline associated (p
0.1) with a marker of the glucose metabolism, these variables were included in the multivariate analyses as well (Table
). In multivariate analyses, the higher the childhood BMI, the higher were glucose, C-peptide, and insulin resistance. Childhood height was associated with glucose and C-peptide as well. Other covariates were not associated with glucose, C-peptide, and insulin resistance in multivariate analyses. Thus, only childhood height and BMI were indicated as a potential mediator and adjusted to the subsequent model.
As can be seen from Table
, adjustment for childhood height (model 2) to the basic model (model 1) did not decrease the coefficients. Additional adjustment for childhood BMI (model 3) led to a considerable decrease in the coefficients of glucose, C-peptide and insulin resistance among children of low educated mothers. After adjustment for age, height, sex, and BMI, the association between low maternal education and glucose, C-peptide, and insulin resistance remained significant.
Replicating the analyses using income adequacy as an indicator of SES
The analyses were repeated using income adequacy as an indicator of SES. Income adequacy was not associated with covariates, except maternal BMI and childhood BMI. The lesser the income adequacy, the higher the BMI. Income adequacy was not associated with the lipid and glucose metabolism in analyses adjusted for age, height, and sex (data not shown).