PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of brbLink to Publisher's site
 
Brain Behav. Sep 2012; 2(5): 678–697.
Published online Aug 15, 2012. doi:  10.1002/brb3.85
PMCID: PMC3489819
Behavioral testing in rodent models of orofacial neuropathic and inflammatory pain
Agnieszka Krzyzanowska and Carlos Avendaño
Department of Anatomy, Histology and Neuroscience, Autonoma University of Madrid, Medical School, Madrid, Spain
Agnieszka Krzyzanowska, Department of Anatomy, Histology and Neuroscience, Autonoma University of Madrid, Medical School, 28029 Madrid, Spain. Tel: +34-91-497-5335; Fax: +34-91-497-5338; E-mail: agnieszka.krzyzanowska/at/uam.es
Funding Information This study was supported by grants from the Fundación Alfonso Martín Escudero, and the Comunidad de Madrid (CAM7S2006-7SAL00305).
Received May 17, 2012; Revised July 10, 2012; Accepted July 13, 2012.
Abstract
Orofacial pain conditions are often very debilitating to the patient and difficult to treat. While clinical interest is high, the proportion of studies performed in the orofacial region in laboratory animals is relatively low, compared with other body regions. This is partly due to difficulties in testing freely moving animals and therefore lack of reliable testing methods. Here we present a comprehensive review of the currently used rodent models of inflammatory and neuropathic pain adapted to the orofacial areas, taking into account the difficulties and drawbacks of the existing approaches. We examine the available testing methods and procedures used for assessing the behavioral responses in the face in both mice and rats and provide a summary of some pharmacological agents used in these paradigms to date. The use of these agents in animal models is also compared with outcomes observed in the clinic.
Keywords: facial pain, pain models, TMD, trigeminal neuralgia
Articles from Brain and Behavior are provided here courtesy of
Wiley-Blackwell