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BMC Vet Res. 2012; 8: 97.
Published online Jun 29, 2012. doi:  10.1186/1746-6148-8-97
PMCID: PMC3488556
Immunohistochemical and morphological features of a small bowel leiomyoma in a black crested macaque (Macaca nigra)
Mónica Aristizabal-Arbelaez,1 Julian Mejía-Restrepo,1 Mauricio Montoya-Flórez,1,2 Fabrizio Grandi,2,4,5 and Francisco Pedraza-Ordóñezcorresponding author1,2,3
1Veterinary Pathology Research Group, Faculty of Agricultural Sciences, Universidad de Caldas, Manizales, Colombia
2Laboratory of Investigative and Comparative Pathology, Department of Veterinary Clinics, Universidade Estadual Paulista, UNESP, Botucatu, Brazil
3Animal Health Department, Universidad de Caldas, Manizales, Colombia
4Department of Pathology, Botucatu Medical School, Universidade Estadual Paulista, UNESP, Botucatu, Brazil
5Department of Diagnostic Pathology, Public Veterinary Hospital, Veterinary Service of National Association of Small Animal Clinicians (Anclivepa), São Paulo, SP, Brazil
corresponding authorCorresponding author.
Mónica Aristizabal-Arbelaez: aristizabalm/at/gmail.com; Julian Mejía-Restrepo: julianmejia82/at/gmail.com; Mauricio Montoya-Flórez: maomontoya53/at/yahoo.es; Fabrizio Grandi: fgrandivet/at/gmail.com; Francisco Pedraza-Ordóñez: fpedraza/at/ucaldas.edu.co
Received February 16, 2012; Accepted June 14, 2012.
Abstract
Background
Spontaneous gastrointestinal neoplasms in non-human primates are commonly seen in aged individuals. Due to genetic similarities between human and non-human primates, scientists have shown increasing interest in terms of comparative oncology studies.
Case presentation
The present study is related to a case of an intestinal leiomyoma in a black crested macaque (Macaca nigra), kept on captivity by Matecaña Zoo, Pereira City, Colombia. The animal had abdominal distension, anorexia, vomiting, diarrhea and behavioral changes. Clinical examination showed an increased volume in the upper right abdominal quadrant caused by a neoplastic mass. The patient died during the surgical procedure. Necropsy revealed several small nodules in the peritoneum with adhesion to different portions of the small and large intestines, liver, stomach and diaphragm. Tissue samples were collected, routinely processed and stained by H&E. Microscopic examination revealed a mesenchymal tumor limited to tunica muscularis, resembling normal smooth muscle cells. Neoplastic cells were positive for alpha-smooth muscle actin and vimentin, and negative for cytokeratin AE1/AE3 by immunohistochemistry. Those morphological and immunohistochemical findings allowed to diagnose the intestinal leiomyoma referred above.
Conclusion
Neoplastic diseases in primates have multifaceted causes. Their manifestations are understudied, leading to a greater difficulty in detection and measurement of the real impact provides by this disease.
Keywords: Neoplasm, Small bowel, Macaca, Monkey, Leiomyoma, Intestine
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