PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of diagpathBioMed CentralBiomed Central Web Sitesearchsubmit a manuscriptregisterthis articleDiagnostic PathologyJournal Front Page
 
Diagn Pathol. 2012; 7: 140.
Published online Oct 9, 2012. doi:  10.1186/1746-1596-7-140
PMCID: PMC3488515
Leiomyoma of the tunica albuginea, a case report of a rare tumour of the testis and review of the literature
Felix Bremmer,corresponding author1 Felix J Kessel,2 Carl L Behnes,1 Lutz Trojan,2 and Elmar Heinrich2
1Department of Pathology, University Medical Centre Göttingen, Robert-Koch-Str. 40, Göttingen, 37075, Germany
2Department of Urology, University Medical Center Göttingen, Robert-Koch-Str. 40, Göttingen, 37075, Germany
corresponding authorCorresponding author.
Felix Bremmer: felix.bremmer/at/med.uni-goettingen.de; Felix J Kessel: u.kleinjohann/at/med.uni-goettingen.de; Carl L Behnes: clbehnes/at/med.uni-goettingen.de; Lutz Trojan: lutz.trojan/at/med.uni-goettingen.de; Elmar Heinrich: elmar.heinrich/at/med.uni-goettingen.de
Received August 9, 2012; Accepted September 27, 2012.
Background
Leiomyomas are benign tumours that originate from smooth muscles. They are often seen in the uterus, but also in the renal pelvis, bladder, spermatic cord, epididymis, prostate, scrotum or the glans penis. Leiomyomas of the tunica albuginea are extremely rare.
Case presentation
A 59-year-old white male has noted an asymptomatic tumour on the right side of his scrotal sac for several years. This tumour has increased slowly and caused local scrotal pain. An inguinal incision was performed, in which the hypoplastic testis, the epididymis and the tumour could be easily mobilized. Macroscopically the tumour showed a solid round nonencapsulated whorling cut surface. Histologically the diagnosis of a leiomyoma was made.
Conclusion
We report here a very interesting and rare case of a leiomyoma of the tunica albuginea. Leiomyomas can be a possible differential diagnosis in this area.
Virtual Slides
http://www.diagnosticpathology.diagnomx.eu/vs/2585095378537599
Keywords: Leiomyoma, Tunica albuginea, Immunohistochemistry
Leiomyomas are benign tumours that originate from smooth muscles cells and are often found as benign lesions arising in the uterus [1,2]. But there are also been seen cases of leiomyomas of the renal pelvis, bladder, spermatic cord, epididymis, prostate, scrotum and the glans penis [1,3-6]. Rare cases of a primary ovarian leiomyoma [7] , leiomyoma of the testis [8] or leiomyoma of the kidney have been also reported [9]. Leiomyomas of the tunica albuginea are extremely rare, and to our knowledge only five cases have been reported so far [10-15]. In case of a bilateral leiomyoma so far only two cases are reported [14]. Here we present a case of a leiomyoma of the tunica albuginea.
Case History
Clinical features
A 59-year-old white male has noted an asymptomatic tumour on the right side of his scrotal sac for several years. Since the size of this tumour has increased and lately sometimes even caused local scrotal pain, he was presented to the clinic of urology.
Physical examination revealed a solid tumour, approximately 5 cm in diameter, on the right scrotal side. The testis on this side felt unremarkable, though it seemed to be very small. Inguinal lymph nodes were not palpable.
Ultrasound of the scrotum revealed a tumour with both echogenic and cystic areas and a diameter of 4cm on the right scrotal side. The testis was hypoplastic but unsuspicious (Figure (Figure1).1). Whether testis or epididymis were affected by the tumour could not be clearly seen in ultrasonography. On the left scrotal side a tumour much smaller in size with a similar sonographic appearance was detected.
Figure 1
Figure 1
In sonographic examination beside a little hypoplastic but unremarkable testis (white arrow) a 5 cm in diamater tumour could be seen (black arrows) (A). The tumour shows echogenic and cystic areas (B).
Choosing an inguinal incision, the hypoplastic testis, the epididymis and the tumour could be easily mobilized. The resection of the tumour was accomplished without harming testis and epididymis. Testis and epididymis were replaced into the scrotum. The postoperative course was uneventful.
Macroscopy and Microscopy
After excision, the tumour tissue was sent to the department of pathology for histological examination. In macroscopical examinantion a solid round nonencapsulated whorling tumour of white colour and a mass of 5 x 3,5x 3.5 cm was seen (Figure (Figure2).2). The testis and epididymis were not involved. Microscopically, the tumour is composed of interlacing and whorling bundles of smooth muscle cells. In these smooth muscle cells vascular channels are seen (Figure (Figure33 A+B). The tumour cells are spindeled containing a centrally located nucleolus and showing no mitotic activity or nuclear atypia. In immunohsitochemical staining the tumour cells were positive for vimentin, desmin, actin. Keratin and s-100 were negative (Figure (Figure33 C-F).
Figure 2
Figure 2
Appearance of cut surface of the right scrotum. A nodular tumour with a whorling surface can be seen.
Figure 3
Figure 3
Histollogically interlacking smooth muscle bundles are seen (A, x40; B, x200). Immunohistologically Actin (C, x100), Vimentin (D, x100) and Desmin (E, x100) show positive expression pattern. In the Ki-67 staining no increased proliferation activity could (more ...)
Leiomyomas are benign tumours orginate from smooth muscles cells. Three different types respective to their origin are known; (1) derivation of arrector pili muscle (piloleiomyoma), (2) derevation of smooth muscles of blood vessels (angioleiomyoma), and (3) genital leiomyoma (p.e. from the smooth muscles of the scrotum) [16]. Tumours of mesenchymal origin in the scrotum are rare, more often cutaneous epithelial tumours are seen [13]. Patients with a leiomyoma of the tunica albuginea are usually about the sixth decades [10-15]. Leiomyomas of the tunica albuginea considered to be of benign behaviour. It shows no invasive growth or metastasis [14]. In sonographic investigations potential differential diagnosis are inflammatory hydrocele, and multiloculated hematocele [17] and a Sertoli cell tumour of the testis [18]. Tumours arising from the testicular tunics are rare and in the most cases fibromas [12]. The potentially aetiology of leiomyomas of the tunica albuginea is discussed controversial. They could arise from the smooth muscle from blood vessels [12] but also may be from totipotent teratoma [10]. Possible differential diagnosis is an inflammatory myofibroblastic tumor (IMT) of the spermatic cord [19]. IMTs are also seen in the lung [20] and are neoplasms of proliferating myofibroblasts, with a variable inflammatory component [19]. Immunohistochemically leiomyomas of the tunica albuginea are positive for Desmin as we could show in the present case report, IMTs are negative [19]. Thus, Desmin is useful to distinguish these two tumours. An orchiectomy is not necessary and instantaneous section should be performed while operation. In this case, the tumour is growing slowly and compressed surrounding structures, causing a hypoplastic testis. Interestingly in ultrasound a second lesion on the other testis from the same appearance could be seen. The patient disagreed excising this lesion because of absent pain in this area. Probably this case is also a bilateral leiomyoma. As the patient did not agree for surgery on the left side, we probably will report in a few years in case of tumour progress and consecutive pain, which was the reason for the patient for surgery on the right side.
Conclusions
This is an extremely rare and interesting case of a leiomyoma of the tunica albuginea. As far as we know only 5 cases of this tumour of the tunica albuginea have been reported. Leiomyomas in this area increasing slowly and may cause scrotal pain. Leiomyomas can be a possible differential diagnosis in this area.
Consent
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
Competing interests
The authors declare that they have no competing interests.
Authors’ contributions
FB and FJK drafted the manuscript and were responsible for the interpretation of the data. FB and CLB were responsible for microscopic and histopathologic elements. LT, FK and EH cared for the patients. EH was responsible for the critical revision of the manuscript. All authors read and approved the final manuscript.
Acknowledgements
None
  • Belis JA, Post GJ, Rochman SC, Milam DF. Genitourinary leiomyomas. Urology. 1979;13(4):424–429. doi: 10.1016/0090-4295(79)90350-9. [PubMed] [Cross Ref]
  • Robboy SJ, Bentley RC, Butnor K, Anderson MC. Pathology and pathophysiology of uterine smooth-muscle tumors. Environmental health perspectives. 2000;108(Suppl 5):779–784. [PubMed]
  • Borri A, Nesi G, Bencini L, Pernice LM. Bizarre leiomyoma of the epididymis. A case report. Minerva urologica e nefrologica = The Italian journal of urology and nephrology. 2000;52(1):29–31. [PubMed]
  • Redman JF, Liang X, Ferguson MA, Savell VH. Leiomyoma of the glans penis in a child. The Journal of urology. 2000;164(3 Pt 1):791. [PubMed]
  • Rosen Y, Ambiavagar PC, Vuletin JC, Macchia RJ. Atypical leiomyoma of prostate. Urology. 1980;15(2):183–185. doi: 10.1016/0090-4295(80)90417-3. [PubMed] [Cross Ref]
  • Park JW, Jeong BC, Seo SI, Jeon SS, Kwon GY, Lee HM. Leiomyoma of the urinary bladder: a series of nine cases and review of the literature. Urology. 2010;76(6):1425–1429. doi: 10.1016/j.urology.2010.02.046. [PubMed] [Cross Ref]
  • Tomas D, Lenicek T, Tuckar N, Puljiz Z, Ledinsky M, Kruslin B. Primary ovarian leiomyoma associated with endometriotic cyst presenting with symptoms of acute appendicitis: a case report. Diagnostic pathology. 2009;4:25. doi: 10.1186/1746-1596-4-25. [PMC free article] [PubMed] [Cross Ref]
  • Kullolli VS, Kullolli S, Pawar S, Gautam D. Leiomyoma of testis -a case report. The Indian journal of surgery. 2011;73(3):233–235. doi: 10.1007/s12262-010-0178-1. [PMC free article] [PubMed] [Cross Ref]
  • Brunocilla E, Pultrone CV, Schiavina R, Vagnoni V, Caprara G, Martorana G. Renal leiomyoma: Case report and literature review. Canadian Urological Association journal = Journal de l'Association des urologues du Canada. 2012;6(2):E87–90. [PMC free article] [PubMed]
  • Albert PS, Mininberg DT. Leiomyoma of the tunica albuginea. The Journal of urology. 1972;107(5):869–871. [PubMed]
  • Aus G, Boiesen PT. Bilateral leiomyoma of the tunica albuginea. Case report. Scandinavian journal of urology and nephrology. 1991;25(1):79–80. doi: 10.3109/00365599109024534. [PubMed] [Cross Ref]
  • Chiaramonte RM. Leiomyoma of tunica albuginea of testis. Urology. 1988;31(4):344–345. doi: 10.1016/0090-4295(88)90098-2. [PubMed] [Cross Ref]
  • Giyanani VL, Hennigan DB, Fowler M, Sanders TJ. Sonographic findings in leiomyoma of postorchiectomy scrotum. Urology. 1985;25(2):204–206. doi: 10.1016/0090-4295(85)90547-3. [PubMed] [Cross Ref]
  • Lia-Beng T, Wei-Wuang H, Biing-Rorn C, Chia-Chun T. Bilateral synchronous leiomyomas of the testicular tunica albuginea. A case report and review of the literature. International urology and nephrology. 1996;28(4):549–552. doi: 10.1007/BF02550965. [PubMed] [Cross Ref]
  • Mak CW, Tzeng WS, Chou CK, Chen CY, Chang JM, Tzeng CC. Leiomyoma arising from the tunica albuginea of the testis: sonographic findings. Journal of clinical ultrasound : JCU. 2004;32(6):309–311. doi: 10.1002/jcu.20039. [PubMed] [Cross Ref]
  • Newman PL, Fletcher CD. Smooth muscle tumours of the external genitalia: clinicopathological analysis of a series. Histopathology. 1991;18(6):523–529. doi: 10.1111/j.1365-2559.1991.tb01479.x. [PubMed] [Cross Ref]
  • Cunningham JJ. Sonographic findings in clinically unsuspected acute and chronic scrotal hematoceles. AJR American journal of roentgenology. 1983;140(4):749–752. [PubMed]
  • Cunningham JJ. Echographic findings in Sertoli cell tumor of the testis. Journal of clinical ultrasound : JCU. 1981;9(6):341–342. doi: 10.1002/jcu.1870090617. [PubMed] [Cross Ref]
  • Yee CH, To KF, Hou SM, Ng CF. Inflammatory myofibroblastic tumor of spermatic cord in undescended testis. Urology. 2009;73(6):e1429–1412. doi: 10.1016/j.urology.2008.05.008. 1423. [PubMed] [Cross Ref]
  • Hammas N, Chbani L, Rami M, Boubbou M, Benmiloud S, Bouabdellah Y, Tizniti S, Hida M, Amarti A. A rare tumor of the lung: inflammatory myofibroblastic tumor. Diagnostic pathology. 2012;7(1):83. doi: 10.1186/1746-1596-7-83. [PMC free article] [PubMed] [Cross Ref]
Articles from Diagnostic Pathology are provided here courtesy of
BioMed Central