44 years old man who complained of painful edema of both hands and feet with limited range of motion that interferes with his work (computer). On physical exam, the skin of the hands was thick and tight wax with clear limitation of motion. A pitting edema was seen on both feet. BP was 140/90 and no synovitis was documented. He developed paresthesias on both hands, mostly during the night, and severe carpal tunnel syndrome was documented (proven by EMG). Then, an inability to press the palms together without a gap (called prayer sign) was documented. Past history reveals insulin-dependent diabetes and HBP (on Altace). The complete blood work-up was within normal limits except positive ANA 1:2560, nucleolar pattern with anti-DNA and ENA negative. Because of an inflammatory condition was first suspected, he was placed on prednisone 50 mg daily x2W with no change. The ACE inhibitor was then suspected to be involved in a bradykinin-induced angioedema and was stopped. The patient treated with plasma-derived C1 inhibitor (Berinert) 1500U.(I.V.) and the initial therapeutic response was modest; with further infusion, no significant change was observed. He did not respond either to anti-bradykinin therapy (ICATIBANT) 30 mg (S.C.).