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Logo of hhmipaabout author manuscriptssubmit a manuscriptHHMI Howard Hughes Medical Institute; Author Manuscript; Accepted for publication in peer reviewed journal
 
From:
Cancer Cell. Author manuscript; available in PMC 2012 November 2.
Published in final edited form as:
Cancer Cell. 2011 November 15; 20(5): 576–590.
doi: 10.1016/j.ccr.2011.09.009

Table 1

Gene Set Enrichment Analysis (GSEA) for Ep5 Cells Treated with Platelets

Gene setsNESNominal p-valueFDR
EMT Signatures
BLICK_EMT-SIG_UP1.993<0.001<0.001
TAUBE_EMT_UP1.3280.0600.060
TAUBE_EMT_DN−2.081<0.001<0.001
ONDER_CDH1_TARGETS_2_UP1.526<0.0010.044
ONDER_CDH1_TARGETS_2_DN−1.832<0.0010.006
TGFβ Signatures
GIAMPIERI_TGFB_UP1.992<0.001<0.001
GIAMPIERI_TGFB_DN−2.576<0.001<0.001
VALCOURT_TGFB_UP1.813<0.0010.005
VALCOURT_TGFB_DN−1.926<0.001<0.001
Cancer Stem Cell Signatures
CREIGHTON_CSC_UP1.675<0.001<0.001
CREIGHTON_CSC_DN−1.778<0.001<0.001
Tumor progression and Metastasis Signatures
VANTVEER_BREAST_CANCER_POOR_PROGNOSIS1.953<0.001<0.001
JAEGER_METASTASIS_UP1.875<0.0010.003

Enrichment of gene sets from the literature (see supplementary information for references). Positive normalized enrichment score (NES) indicates enrichment in platelet-treated Ep5 cells; negative NES indicates enrichment in untreated Ep5 cells. FDR (false discovery rate).