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Logo of aidsrestherBioMed CentralBiomed Central Web Sitesearchsubmit a manuscriptregisterthis articleAIDS Research and Therapy
AIDS Res Ther. 2012; 9: 30.
Published online Oct 11, 2012. doi:  10.1186/1742-6405-9-30
PMCID: PMC3485617
ART adherence changes among patients in community substance use treatment: a preliminary analysis from MACH14
Marc I Rosen,corresponding author1 Anne C Black,1 Julia H Arnsten,2 Jane M Simoni,3 Glann J Wagner,4 Kathleen Goggin,5 Robert H Remien,6 Carol E Golin,7 Yan Wang,8 David Bangsberg,9 and Honghu H Liu10, the MACH14 Study Group
1Department of Psychiatry, Yale University School of Medicine, New Haven, CT; VA Connecticut Healthcare System, West Haven, CT, 06516, USA
2Departments of Medicine and Psychiatry & Behavioral Sciences, Albert Einstein College of Medicine and Montefiore Medical Center, Einstein/Montefiore Center for AIDS Research, Bronx, NY, 10467, USA
3Department of Psychology, University of Washington, Seattle, WA, 98195, USA
4Rand Corporation Health Unit, Santa Monica, CA, 90407, USA
5Department of Psychology, University of Missouri-Kansas City, Kansas City, MO, 64110, USA
6HIV Center for Clinical and Behavioral Studies, NY State Psychiatric Institute and Columbia University, New York, NY, 10032, USA
7UNC Departments of Medicine and Health Behavior & Health Education; UNC Center for AIDS Research, Cecil G. Sheps Center for Health Services Research, Chapel Hill, NC, 27599, USA
8Department of Biostatistics, University of California Los Angeles (UCLA), Los Angeles, CA, 90095, USA
9Mbarara University of Science and Technology; Harvard Medical School; Ragon Institute of MGH, Harvard, and MIT; Division of Global Health Equity at Brigham’s and Women’s Hospital; Massachusetts General Hospital Center for Global Health, Boston, MA, 02114, USA
10Schools of Dentistry, Medicine and Public Health, University of California Los Angeles (UCLA), Los Angeles, CA, 90095, USA
corresponding authorCorresponding author.
Marc I Rosen: Marc.Rosen/at/; Anne C Black: Anne.Black/at/; Julia H Arnsten: Jarnsten/at/; Jane M Simoni: Jsimoni/at/; Glann J Wagner: Gwagner/at/; Kathleen Goggin: Goggink/at/; Robert H Remien: Rhr1/at/; Carol E Golin: Carol_Golin/at/; Yan Wang: Wangyan/at/; David Bangsberg: David_Bangsberg/at/; Honghu H Liu: HHliu/at/
Received June 29, 2012; Accepted September 28, 2012.
Opiate substitution treatment has been associated with better adherence to lifesaving antiretroviral medications, but the impact of other substance abuse treatment on adherence is unknown.
In this study, 215 patients who had been in adherence-focused research studies provided electronically-measured adherence data and a measure of whether the patient had recently been in substance abuse treatment. Recent engagement in substance abuse treatment was independently associated with significantly higher adherence, after covarying for recent substance use and other factors potentially affecting adherence.
The findings suggest that substance abuse treatment is associated with better adherence. Potential mechanisms by which substance abuse treatment improves adherence, such as more stability or more future-orientation, require further study.
Keywords: Medication adherence, AIDS, Substance abuse, Treatment
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