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Logo of anclinmicBioMed CentralBiomed Central Web Sitesearchsubmit a manuscriptregisterthis articleAnnals of Clinical Microbiology and Antimicrobials
 
Ann Clin Microbiol Antimicrob. 2012; 11: 15.
Published online Jun 12, 2012. doi:  10.1186/1476-0711-11-15
PMCID: PMC3483011
Analgesic and antibutyrylcholinestrasic activities of the venom prepared from the Mediterranean jellyfish Pelagia noctiluca (Forsskal, 1775)
Yosra Ayed,1 Afef Dellai,2 Hedi Ben Mansour,2 Hassen Bacha,corresponding author1,3 and Salwa Abid1
1Laboratory for Research on Biologically Compatible Compounds (LRSBC), Faculty of Dentistry, Monastir university, Rue Avicenne, 5019, Monastir, Tunisia
2Laboratory for Biotechnology and Bio Geo Resources Valorisation (LBVBGR), High Institute of Biotechnology of Sidi Thabet University of Manouba, 2020, Ariana, Tunisia
3University of Jendouba, Cité AlFaeiz rue Jamil Boutheina, Jendouba, 8100, Tunisia
corresponding authorCorresponding author.
Yosra Ayed: lunayousr/at/yahoo.fr; Afef Dellai: afef.dellai/at/hotmail.com; Hedi Ben Mansour: hbenmansour/at/hotmail.com; Hassen Bacha: hassen-bacha/at/fmdm.rnu.tn; Salwa Abid: salwaabid/at/yahoo.fr
Received December 19, 2011; Accepted May 13, 2012.
Abstract
Background
Toxins derived from jellyfishes have been exploited as a model for the development of new drug promising applications to treat neurodegenerative diseases. The present work is aimed to evaluate the acute toxicity of crude venom of Pelagia noctiluca and then to screen the analgesic and antibutyrylcholinestrasic (anti-BuChE) activities of the crude venom and its fractions.
Methods
Sephadex G75 gel was used to separate crude venom of Pelagia noctiluca, which led to some fractions. In addition, in vivo analgesic and in vitro plasma antibutyrylcholinestrasic activities were carried out with Pelagia crude venom and its fractions respectively.
Results
The crude venom and its fractions displayed analgesic and anti-BuChE activities at different doses without inducing acute toxicity. Fraction 2 possesses the highest analgesic and antibutyrylcholinestrasic properties. The crude venom and fraction 1 had shown to possess less significant inhibitory activity against analgesic and antibutyrylcholinestrasic models.
Conclusions
Based on this study, the crude venom of Pelagia noctiluca is found to be a useful tool for probing pharmacological activity. The purification and the determination of chemical structures of compounds of active fractions of the venom are under investigation.
Keywords: Pelagia noctiluca, Venom, Jellyfish, Analgesic activity, Anti-Butyrylcholinesterasic activity
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