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From:
Thromb Haemost. Author manuscript; available in PMC 2012 October 26.
Published in final edited form as:
Thromb Haemost. 2004 December; 92(6): 1312–1319.
doi: 10.1267/THRO04061312

Table 2

Associations between thrombotic events (AE, VE, or TE) and thrombophilic features, presented as crude and aPL-stratified ORs and 95% CIs.

VEAETE
APCR phenotype (n = 404)*
 N (%) events in APCR-positive participants (n = 118)17 (14.5)14 (12.0)26 (22.2)
 N (%) events in APCR-negative participants (n = 287)22 (7.7)24 (8.4)40 (13.9)
 Crude OR (95% CI)2.05 (1.04 to 4.01)1.49 (0.74 to 2.99)1.76 (1.02 to 3.06)
 Stratified OR (95% CI)
  aPL+1.54 (0.50 to 4.73)3.44 (0.96 to 12.28)1.65 (0.62 to 4.42)
  aPL−1.67 (0.68 to 4.10)0.58 (0.19 to 1.76)1.29 (0.62 to 2.66)
Factor V Leiden mutation (APCR genotype) (n = 406)
 N (%) events in participants with mutation (n = 18)5 (27.8)1 (5.6)5 (27.8)
 N (%) events in participants without mutation (n = 388)34 (8.8)34 (8.8)60 (15.5)
 Crude OR (95% CI)4.00 (1.35 to 11.91)0.61 (0.08 to 4.74)2.10 (0.72 to 6.11)
 Stratified OR (95% CI)
  aPL+1.69 (0.14 to 19.84)2.42 (0.20 to 28.85)0.90 (0.078 to 10.43)
  aPL−6.06 (1.76 to 20.93)not available2.94 (0.89 to 9.73)
Elevated serum homocysteine (n = 405)§
 N (%) events in participants with elevated serum homocysteine (n = 33)6 (18.2)9 (27.3)12 (36.4)
 N (%) events in participants with normal serum homocysteine (n = 372)34 (9.1)27 (7.3)54 (14.5)
 Crude OR (95% CI)2.21 (0.85 to 5.73)4.79 (2.03 to 11.33)3.37 (1.56 to 7.24)
 Stratified OR (95% CI)
  aPL+1.79 (0.40 to 8.06)8.75 (1.93 to 39.57)4.40 (1.00 to 19.39)
  aPL−2.06 (0.57 to 7.49)3.04 (0.94 to 9.80)2.69 (1.00 to 7.23)
MTHFR C677T mutation (n = 407)||
 N (%) events in participants with mutation (n = 230)19 (8.3)22 (9.6)36 (15.7)
 N (%) events in participants without mutation (n = 177)20 (11.3)13 (7.3)29 (16.4)
 Crude OR (95% CI)0.71 (0.37 to 1.37)1.33 (0.65 to 2.73)0.95 (0.56 to 1.62)
 Stratified OR (95% CI)
  aPL+0.41 (0.13 to 1.26)1.09 (0.33 to 3.63)0.69 (0.26 to 1.81)
  aPL−1.07 (0.45 to 2.58)1.63 (0.65 to 4.12)1.21 (0.61 to 2.40)
Prothrombin gene G20210A mutation (n = 407)||
 N (%) events in participants with mutation (n = 17)3 (17.7)0 (0.0)3 (17.7)
 N (%) events in participants without mutation (n = 390)36 (9.2)35 (9.0)62 (15.9)
 Crude OR (95% CI)2.11 (0.58 to 7.68)Not available1.13 (0.32 to 4.06)
 Stratified OR (95% CI)
  aPL+Not availableNot availableNot available*
  aPL−4.32 (1.11 to 16.80)Not available2.15 (0.57 to 8.08)
*APCR phenotype is unknown for 4 aPL+ and 7 aPL− persons.
Factor V Leiden genotype is unknown for 2 aPL+ and 7 aPL− persons.
OR could not be calculated because of insufficient numbers of events.
§Homocysteine levels are unknown for 2 aPL+ and 8 aPL− persons.
||MTHFR and prothrombin genotypes are unknown for 2 aPL+ and 6 aPL− persons.