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From:
Thromb Haemost. Author manuscript; available in PMC Oct 26, 2012.
Published in final edited form as:
Thromb Haemost. Dec 2004; 92(6): 1312–1319.
doi: 10.1267/THRO04061312
Table 1
Baseline characteristics of the cohort.
aPL-positive
N=75
aPL-negative
N=340
Total
N = 415*
Demographic
Age in years, mean (SD)47.7 (13.8)46.2 (14.3)46.5 (14.2)
Gender, n (%) female61 (81.3)284 (83.5)345 (83.1)
Ethnicity, n (%) Caucasian68 (90.7)282 (82.9)350 (84.3)
Cardiovascular risk factors
FMH, n (%)48 (64.0)153 (45.0)201 (48.4)
SLE, n (%)*26 (34.7)59 (17.4)85 (20.5)
Smoking, n (%)23 (30.7)92 (27.1)115 (27.7)
HBP (%)17 (22.7)50 (14.7)67 (16.1)
DM (%)5 (6.7)18 (5.3)23 (5.5)
Thyroid disorder7 (9.3)53 (15.7)60 (14.5)
Medication
Prednisone (%)11 (14.7)25 (7.4)36 (8.7)
Hydroxychloroquine (%)14 (18.7)40 (11.8)54 (13.0)
Acetylsalicylic acid, n (%)20 (26.7)41 (12.1)61 (14.7)
Warfarin, n (%)18 (24.0)14 (4.1)32 (7.7)
Estrogen, n (% of women)8 (13.1)54 (19.0)62 (18.0)
Coagulation profile
Antithrombin, Protein C, and/or Protein S deficiencies1 (1.3)14 (4.1)15 (3.6)
APCR phenotype34 (47.9)83 (24.9)117 (29.0)
Hyperhomocysteinemia (positive >15 U/L)§9 (12.3)24 (7.2)33 (8.2)
Factor V Leiden||
  Heterozygous3 (4.1)15 (4.5)18 (4.4)
  Homozygous0 (0.0)0 (0.0)0 (0.0)
Prothrombin gene G20210A mutation**
  Heterozygous3 (4.1)14 (4.2)17 (4.2)
  Homozygous0 (0.0)0 (0.0)0 (0.0)
MTHFR C677T mutation**
  Heterozygous31 (42.5)145 (43.4)176 (43.2)
  Homozygous7 (9.6)47 (14.1)54 (13.3)
Obstetric Events
Miscarriages, n (% of women)0 (0.0)1 (0.4)1 (0.3)
Spontaneous abortions, n (% of women)14 (23.0)28 (9.9)42 (12.2)
Premature births, n (% of women)5 (8.2)17 (6.0)22 (6.4)
Reported thrombotic events (arterial or venous), n (%)36 (48.0)76 (22.4)112 (27.0)
Confirmed thrombotic events (arterial or venous), n (%)28 (37.3)41 (12.1)69 (16.6)
 Arterial events only, n (%)10 (13.3)18 (5.3)28 (6.7)
 Venous events only, n (%)13 (17.3)17 (5.0)30 (7.2)
 Both arterial and venous events, n (%)5 (6.7)6 (1.8)11 (2.6)
 >1 thrombotic events, n (%)11 (14.7)16 (4.7)27 (6.5)
*One person has been excluded from the analysis because of missing information on aPL status and thrombophilic factors.
N = 61/284 aPL+/aPL− women.
N = 404. APCR phenotype is unknown for 4 aPL+ and 7 aPL− persons.
§N = 405. Homocysteine levels are unknown for 2 aPL+ and 8 aPL− persons.
||N = 406. Factor V Leiden is unknown for 2 aPL+ and 7 aPL− persons.
**N = 407. Prothrombin and MTHFR genotypes are unknown for 2 aPL+ and 6 aPL− persons.
††N = 413. Thyroid function is unknown for 2 aPL− persons.