We thank the patients and families who participate in the LS-1 study.
NET-PD Steering Committee
Karl Kieburtz, MD, MPH (Principal Investigator, Coordination Center); University of Rochester, Rochester, NY; Barbara Tilley, PhD (Principal Investigator, Statistical Center); University of Texas, Houston, TX; Debra Babcock, PhD, MD, Wendy Galpern, MD, PhD; National Institutes of Health, Bethesda, MD; Robert Hauser, MD; University of South Florida, Tampa, FL; Connie Kawai, RN, BSN, CCRC; University of Southern California, Los Angeles, CA; Brad A. Racette, MD; Washington University School of Medicine, St. Louis, MO; Bernard Ravina, MD, MSCE; Biogen Idec, Cambridge, MA; Sue Reichwein, CCRC; University of Pennsylvania, Philadelphia, PA; G. Webster Ross, MD, Pacific Health Research & Education Institute, Honolulu, HI; Kathleen M Shannon, MD; Rush University Medical Center, Chicago, IL; Oksana Suchowersky, MD; University of Calgary, AB, Canada; Caroline M Tanner MD, PhD; The Parkinson’s Institute, Sunnyvale, CA, Jessie Tatsuno Roth, RN, BSN University of California San Francisco, San Francisco, CA..
Participating Investigators and Coordinators and Associated Grants
Ray L Watts, MD, Harrison Walker, MD, Anthony Nicholas, MD, PhD, Natividad Stover, MD, Jeff Worrell; University of Alabama, Birmingham, AL (U10 NS044547); Robert Hauser, MD, Juan Sanchez-Ramos, MD, PhD, Theresa A Zesiewicz, MD, Theresa McClain, RN, SN, ARNP, Deborah Burke, MD, Holly Delgado, RN, Summer Carter, MSPH, Gerry Piper, Patti Lowe, LPN; University of South Florida, Tampa(U10 NS044425), FL; Mark F. Lew, MD, Mickie Welsh, RN, DNS, Giselle Petzinger, MD, Daniel Togasaki, MD, PhD, Jennifer S Hui, MD, Connie Kawai, RN, BSN, CCRC, Gina Barles; University of Southern California, Los Angeles, CA (U10 NS044462); Jorge L. Juncos, MD, Alan Freeman, MD, Mary Louise Musante Weeks, RN, Linda McGinn, RN, Rebecca McMurray, RN, BS, Gregg Everhart, RN, Lisa Miyatake, BS, Elaine Sperin, LPN, Cathy Wood-Siverio, MS; Emory University School of Medicine, Atlanta, GA (U10 NS053379); Julie Carter, RN, MN, ANP, Matthew Brodsky, MD, Pamela Andrews, Stephanie Crocker, BA, Andrea Jones, BS, Megan Murray, MA, Carolyn McCain, BS, CNA, April Wilson, BS, Karen Kerr, BS; Oregon Health & Science University, Portland, OR (U10 NS044483); Maureen Leehey, MD, Deborah Hall, MD, Jacquelyn Bainbridge, PharmD, Sarah Johnson, PharmD, Michael Egeberg, PharmD, Jeffery Clark, PharmD; University of Colorado (Denver), Anschutz Medical campus, Aurora, CO (U10 NS044479); Zoltan Mari, MD, Ted Dawson, MD, PhD, Laura Marsh, MD, Joseph Savitt, MD, PhD, Becky Dunlop, RN, Melissa Gerstenhaber, RNC, MSN, Arita McCoy RN; Johns Hopkins University, Baltimore, MI (U10 NS 044474); Richard B. Dewey, Jr., MD, Padraig O’Suilleabhain, MD, Shilpa Chitnis, M.D, Brigid Hayward, RN, Allison Johnson, BS, Amit Gode, MPH, Giselle Huet, MS, Peter Carreon; University of Texas Southwestern Medical Center, Dallas, TX (U10 NS 044545); Michael J. Aminoff, MD, FRCP, Chadwick W. Christine, MD, Jessie Tatsuno Roth, RN, BSN, Mariann DiMinno, RN, MA, CNS; University of California San Francisco, San Francisco, CA (U10 NS044460); Hubert Fernandez, MD, Ramon Rodriguez, MD, Irene Malaty MD, Sonia Reback, BS, Gordon Brown, Kathryn Jemmott, MA, Margaret Neilson, JD, Anne Smith-Bova, Stacy Merritt, MA, Camille Swartz, BA, Kyle Rizer, Erin Hastings, PhD; University of Florida, Gainesville, FL (U10 NS053381); Burton Scott, MD, Mark Stacy, MD, Joanne Field, BSN, RN, Karen Grace, RN, Deborah Koltai Attix, PhD; Duke University, Durham, NC (U10 NS044453); Richard Zweig, MD, Robert N Schwendimann, MD, Colette Hilliard, MS, Labrillia Johnson; LSU Health Science Center Shreveport, Shreveport, LA (U10 NS053370); John L Goudreau DO, PhD, Glen Ackerman, MD, Doozie Russell; Michigan State University, East Lansing, MI (U10 NS053380); Kathleen M Shannon, MD, Jean A Jaglin, RN, CCRC, Lucia M Blasucci, RN CCRC; Rush University Medical Center, Chicago, IL (U10 NS044475); Oksana Suchowersky, MD, Scott Kraft, MD, Lorelei Derwent, RN, Nancy Labelle, RN, BN; University of Calgary, AB, Canada U10 NS044431); Martha Nance, MD, Sotirios Parashos, MD, Catherine Wielinski, MPH, John Worley, DO, Susan Peterson, RN, Patricia Ede, RN, Sarah Lenarz, CMA; Struthers Parkinson’s Center, Golden Valley, MI (U10 NS044466); Andrew Siderowf, MD, Howard I Hurtig, MD, Matthew Stern, MD, Amy Colcher, MD, Stacy Horn, DO, Sue Reichwein, CCRC; University of Pennsylvania, Philadelphia, PA (U10 NS044451); Caroline Tanner, MD, James Tetrud, MD, J William Langston, MD, Melanie Brandabur, MD, Grace Liang, Neng C Huang, MD, PhD, Tracy Stewart, RN, Katie Ersted, RN, Katharine Smith, RN, Cheryl Lawrence, BA, Julie Bergman, RN, Liza Reys, Anna Woods, RN, NP, Alice Brown, RN, NP; The Parkinson’s Institute, Sunnyvale, CA (U10 NS044465);; David K. Simon, MD, PhD, Daniel Tarsy MD, Linda Paul, NP, Peggy Rose, RN, Althea Silver, MPH, BSN, RN Shannon Donovan, BA, Chen Lim, BA, Jared Miller, BS, Lauren Kraics, BS; Beth Israel Deaconess Medical Center, Boston, MA (U10 NS044482);; Andrew Feigin, MD, Michael Pourfar, MD, Barbara Shannon, RN, Margaret Marie Cox, RN, BSN; North Shore-LIJ Health System, Manhasset, NY (U10 NS044484); Rodger J. Elble, MD, PhD, Charlene Young, RN, MSN, CFNP, Dolly Kelley, RN, CCRC, Southern Illinois University, Springfield, IL (U10 NS044450); Kelvin Chou, MD, Roger Albin, MD, Kristine Wernette, RN, MS; University of Michigan, Ann Arbor, MI (U10 NS044504); Anne-Marie Wills, MD, Lewis Sudarsky, MD, Georgette Hage, MD, Sarah Pearl Aronow-Werner, BA; Brigham & Women’s Hospital, Boston, MA (U10 NS053369); Carlos Singer, MD, Alicia Facca, MD, Bruno V Gallo, MD, Cenk Sengun, MD, Fatta Nahab, MD, Marian A Perez, AA, Monica Quesada, Anita Blenke, PA-C MS; University of Miami, Miami, FL (U10 NS044437); Vanessa Hinson, MD PhD, Kenneth Bergmann, MD FAAN, Gonzolo Revuelta, DO, Vicky Salak, FNP, Jennifer Zimmerman, RN, Amy Delambo, RN; Medical University of South Carolina, Charleston, SC (U10 NS053372); G. Webster Ross, MD, Helen Petrovitch, MD, Stephanie Terashita, RN; Pacific Health Research & Education Institute, Honolulu, HI (U10 NS044448); Wayne Martin, MD, Richard Camicioli, MD, Germaine McInnes, RN, Ingrid Scott, RN, Pamela King, BScN, RN, Marguerite Wieler, MSc; University of Alberta, Edmonton, AB, Canada (U10 NS044426); Brad A. Racette, MD, Joel S Perlmutter, MD, Samer Tabbal, MD, Susan Criswell, MD, Allison Wright, MD, Patricia Deppen, RN, BSN, MA, Melissa Ammel, Mary Pecoraro, RN, BSN, Kathleen Wharton; Washington University, St. Louis, M (U10 NS044455); Lisa Shulman, MD, William Weiner, MD, Stephen Reich, MD, Paul Fishman, MD, Bradley Robottom, MD, Renzo Figari, Michelle Cines, RN, Nancy Zappala, RN; University of Maryland School of Medicine, Baltimore, MD (U10 NS044446); Robert Hamill, MD, James Boyd, MD, Jessy Gardner, BA, Shannon Lenox, BS, Christine A Potter, BA, Jennifer Young, CCRP, Sharon Kenney, RN, Colette Oesterle, BA, Christopher Ingvoldstad, BA, Sarah Waterman, Shannon Lucy, BA; University of Vermont, Burlington, VT (U10 NS044501); Tanya Simuni, MD, Aleksandar Videnovic, MD, Onur Melen, MD, Cindy Zadikoff, MD FRCPC, Karen Williams, Teresa Kuhta, BS, Elaina Ziehm; Northwestern University, Chicago, IL(U10 NS053377); Rajesh Pahwa, MD, Kelly Lyons, PhD, Amy Parsons, RN BSN, Tamara Gales, LPN, Carey Mack, RN, Meghan Ehlinger, BS; University of Kansas Medical Center, Kansas City, KS (U10 NS044469); Franca Cambi, MD, John T. Slevin, MD, Renee Wagner RN, CCRC, Chris Miara, MA; University of Kentucky, Lexington, KY (U10 NS053368); Stephen Gollomp, MD, Gwyn M Vernon, MSN, CRNP, Sabreen Raza, Randi Gollomp, BS, RN, Judy Spahr, CCRP, CTR; Thomas Jefferson University/Lankenau Hospital, Wynnewood, PA; David J Coffey, MD, Pauline R LeBlanc, BS, Tracy Ostler, BS Dartmouth Hitchcock Medical Center, Lebanon, NH; Jayaraman Rao, MD, Robert Felberg, MD, Frank Oser, MD, Maureen Cook, RN, BSN, Carol Marques, Patricia Schaefer, Marilyn Carleton; Ochsner Clinic Foundation, New Orleans, LA U10 NS044471); Ivan G. Bodis-Wollner, MD, William Lytton, MD, Jean Daniel Francois, MD, Thomas Mayer, PSYD, Patricia Kavanagh, MD, Mohammedyusuf Hajee, MD, Elizabeth Hayes, ED D, RN, Zoe Kyle M Moffitt, RN, MFA, Sofya Glazman, MD; SUNY Downstate Medical Center, Brooklyn, NY (U10 NS044454); Jay Schneider, MD, Tsao-Wei Liang, MD, Stephanie Sendek, Teresa Barron, RN, Christine Randazzo, RN; Thomas Jefferson University, Philadelphia, PA (U10 NS044481); Joohi Shahed, MD, Joseph Jankovic, MD, William Ondo, MD, Christopher John Kenney, MD, Octavian Adam, MD, Christine Hunter, RN; Baylor College of Medicine, Houston, TX (U10 NS044441); Kapil Sethi, MD, John C Morgan, MD, PhD, Buff Farrow, BS, ED; Georgia Health Sciences University, Augusta, GA (U10 NS044464); Danna Jennings, MD, Kenneth Marek, MD, David Russell, MD, PhD, Rowena Tabamo, MD, Barbara Fussell, RN, Tammie Kelsey, LPN, James Behan, RN, Pam Becker, RN, Laura Leary, BS; Institute for Neurodegenerative Disorders, New Haven, CT (U10 NS044505); Daniel D Truong, MD, Mayank Pathak, MD, Karen Frei, MD, An Hao Tran, RN, Michelle Tran, BA, Jassie Sombai; The Parkinson’s & Movement Disorder Institute, Fountain Valley, CA (U10 NS053387); G. Frederick Wooten, MD, James Bennett, MD, PhD, Joel Trugman, MD, Madaline B Harrison, MD, Elke Rost-Ruffner, RN, BSN, Margaret F Keller, RN, MS, CCRC, Robert B Davis, NP; University of Virginia, Charlottesville, VA (U10 NS044427); John Fang, MD, Fenna Phibbs, MD, MPH, Dorothy Shearon, RN; Vanderbilt University Medical Center, Nashville, TN (U10 NS044555); Richard Burns, MD, Rohit Dhall, MD, MSPH, Anwar Ahmed, MD, Holly Shill, MD, Nicklesh Thakur, MD, Guillermo Moguel-Cobos, MD, Michal Gostkowski, DO, Lynn L Marlor, BSN, MSHS, Diane Gates, RN, Edith Simpson; Barrow Neurological Institute, Phoenix, AZ (U10 NS044458); Jacob I Sage, MD, Anette Nieves, MD, Debbie Caputo, RN, MSN, Emily Kosa, RN; UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ; (U10 NS044415) Frank Skidmore, MD, Amy Coenen, MSN, ARNP, Helen Dunn, RN MSN, Stacy McCombs, Shirley Roessner, LPN, Linda Sawka, RN; Malcolm Randall VA Medical Center, Gainesville, FL; Zhigao Huang, MD, PhD, Lisa Smith, CRC, Rhonda Calhoun, RN; University of Florida Jacksonville, Jacksonville, FL; Joanne Wojcieszek, MD, Joann Belden, RN, Katie Price, Marsha Hughes-Gay, RN; Indiana University School of Medicine, Indianapolis, IN (U10 NS044472); Arif Dalvi, MD, Michael Rezak, MD, PhD, Susie Ro, MD, Kathy Kujawa, MD, PhD, Kevin Novak, PhD, Sandra Vergenz, RN, Gina Medalle, RN, BSN, Susan Silvio, RN; North Shore University Health System Research Institute, Glenview, IL.
NET-PD Statistical Center; Keith Burau, PhD, Rong Ye, MS, Sheng Luo, PhD; University of Texas Health Science Center at Houston, Houston, TX;
NET-PD Clinical Trials Coordination Center Staff; Christine Weaver, CCRP, Gina Lau, BS, Ann Stoutenburg, CCRC, Renee Wilson, MA, David Shprecher DO, Laith Khadim, MD, Debbie Frasier, BS, Debbie Baker, AAS, Beverly Olsen, BA, Susan Bennett, AAS, Jennifer Harman, PhD, CCRP, Irenita Gardiner, RN, CCRC; University of Rochester, Rochester, NY.
NET-PD Consultants; Christopher Goetz, MD; Rush University Medical Center, Chicago, IL; David Ploth, MD; Medical University of South Carolina, Charleston, SC.
Data Safety Monitoring Board; Cynthia R. Gross, PhD (Chair); University of Minnesota, Minneapolis, MN; Karen L. Bell, MD, Columbia University, NY, NY; Donna T. Chen, MD, MPH; University of Virginia Health System, Charlottesville, VA; Robert Foley, MD, United States Renal Data System Coordinating Center, Minneapolis, MN; David E. Levy, MD; Neurobiological Technologies, Inc., Mahwah, NJ; Robert L. Rodnitzky, MD; University of Iowa College of Medicine, Iowa City, IA.
Oversight Board; K. Michael Welch, MD (Chair); Rosalind Franklin University of Medicine and Science, North Chicago, IL; M. Flint Beal, MD; Weill Medical College of Cornell University, New York, NY; Jeffrey L. Cummings, M.D., UCLA Alzheimer Disease Center, Los Angeles, CA; David J. Edwards, Pharm.D., Wayne State University, Detroit, MI; Stanley Fahn, MD, Bruce Levin, PhD; Columbia University, New York, NY; Russell G. Katz, MD; Food and Drug Administration, Rockville, MD; Deborah B. Marin, MD, C. Warren Olanow, MD; Mount Sinai School of Medicine, New York, NY; Jeffrey C. Martin, Esq.; Goodwin Proctor LLP, Rockville, MD; Diane DiEuliis, PhD; Health and Human Services, Washington, DC; Steven Piantadosi, MD, PhD; Cedars-Sinai Medical Center, Los Angeles, CA; William J. Powers, MD; University of North Carolina School of Medicine, Chapel Hill, NC; Alison Wichman, MD; National Institutes of Health, Bethesda, MD.
NIH; Debra Babcock PhD, MD; Wendy Galpern, MD, PhD; John Marler, MD; Joanne Odenkirchen; National Institute of Neurological Disorders and Stroke, Bethesda.
Funding/Support: This study was sponsored by the National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke. The authors report no other financial disclosures related to the content of this manuscript.