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Allergy Asthma Immunol Res. Nov 2012; 4(6): 351–356.
Published online Jun 29, 2012. doi:  10.4168/aair.2012.4.6.351
PMCID: PMC3479229
Elevated Serum Levels of IL-21 in Kawasaki Disease
Yon Jung Bae,1 Mi Hyun Kim,1 Hae Yong Lee,corresponding author1 Young Uh,2 Mee Kyung Namgoong,1 Byung Ho Cha,1 and Jin-Kyong Chuncorresponding author1
1Department of Pediatrics, Yonsei University Wonju College of Medicine, Wonju Christian Hospital, Wonju, Korea.
2Department of Laboratory Medicine, Yonsei University Wonju College of Medicine, Wonju Christian Hospital, Wonju, Korea.
corresponding authorCorresponding author.
Correspondence to: Jin-Kyong Chun, MD, PhD, Department of Pediatrics, Yonsei University Wonju College of Medicine, Wonju Christian Hospital, 162 Ilsan-dong, Wonju 220-701, Korea. Tel: +82-33-741-1281; Fax: +82-33-732-6229; jkchunped/at/yonsei.ac.kr
Co-corresponding author: Hae Yong Lee, MD, PhD, Department of Pediatrics, Yonsei University Wonju College of Medicine, Wonju Christian Hospital, 162 Ilsan-dong, Wonju 220-701, Korea. Tel: +82-33-741-1286; Fax: +82-33-732-6229; reehy/at/yonsei.ac.kr
Received December 24, 2011; Revised March 6, 2012; Accepted April 10, 2012.
Abstract
Purpose
The serum level of immunoglobulin (Ig)E has been reported to be elevated in patients with Kawasaki disease (KD). We investigated whether interleukin (IL)-21, rather than IL-4, could be related to elevated serum levels of IgE in KD.
Methods
Sera from 48 patients with KD and 12 controls with high fever were collected to determine the level of IgE using an immunoassay system and the levels of IL-4 and IL-21 were determined using enzyme-linked immunosorbent assay kits.
Results
The median IL-21 level of KD patients was significantly elevated, at 499.5 pg/mL (range: <62.5-1,544 pg/mL), whereas that of controls was <62.5 pg/mL (<62.5-825 pg/mL; P<0.001). The median IL-4 level of KD patients was not elevated (4.0 pg/mL; 2.1-7.6 pg/mL). The median level of total IgE in KD patients was 58.0 IU/mL (5-1,109 IU/mL). No statistically significant correlation was found between IL-21 and total IgE levels (Spearman's R=0.2; P=0.19).
Conclusions
Patients with KD have elevated levels of IL-21 in the serum. IL-21 may play a role in the pathogenesis of KD.
Keywords: Interleukin-21, immunoglobulin E, mucocutaneous lymph node syndrome
Articles from Allergy, Asthma & Immunology Research are provided here courtesy of
Korean Academy of Asthma, Allergy and Clinical Immunology and Korean Academy of Pediatric Allergy and Respiratory Disease