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Oral Treatment of HSS-888 Reduces Both Soluble and Insoluble Aβ1-40, 42 Levels in Mouse Brain Homogenates. (A) Brain homogenates
prepared from Tg2576 mice treated with animal pellets only (control), HSS-888, or THC. H20 soluble Aβ1-40, 42 were analyzed
by ELISA. (B) Insoluble Aβ1-40, 42 prepared with 5 M guanidine were analyzed by ELISA. Data are presented as mean ± SD of Aβ1-40 or
Aβ1-42 (pg/mg protein) separately. For (A) and (B), a t-test revealed a significant between-groups difference for either soluble or insoluble
Aβ1-40, 42 (P < 0.05 for each comparison) as indicated. Mean ± standard deviation for each group [n = 20 (10 male/10 female) for Controltreated,
HSS-888-treated, and THC-treated Tg2576 mice].