A diagnosis of anastomotic leak was made and conservative management was followed for the next 17 days. Feeds were continued through the trans-anastomotic tube, but the chest tube continued to drain fluid. On the 26th day a re-exploration was planned because of failed conservative treatment. However, on parents request the baby was referred to us for further management.

Patient was a baby girl with a weight of 1030 grams. She was hemodynamically stable. A chest tube was reinserted which was removed earlier. It drained serous fluid. Blood investigations showed Hemoglobin of 13 gm%, total white cell counts 15000/mm3. A sepsis screen was positive. Gavage feeding was started. On the following day the output from the chest tube increased and became cloudy. Biochemical analysis of the fluid showed 661.5 mg/dl of triglycerides against a serum triglyceride level of 104.5 mg/dl. A diagnosis of chylothorax was made. The baby had already received ceftriaxone and meropenem. Meropenem was continued. Blood culture did not grow any organism. For the next four days the chest drain produced more than 70 ml fluid per day. The baby was in a catabolic phase. Total parenteral nutrition (TPN) was not considered useful as the patient had already spent almost four weeks in the hospitals and was on antibiotics for nearly the entire period. Septic complications of TPN were thought to be too risky. It was decided to operate upon the patient.

Right postero-lateral thoracotomy was performed on the 7th day of admission. A trans-pleural approach was used. The anastomosis was intact. Clear lymphatic fluid found leaking from the mediastinum diffusely below the anastomosis. No clear leak point could be identified. Two ml of fibrin sealant was applied over the area. The clot covered the entire mediastinal surface and the lymphatic leak stopped. A chest tube of size 10Fr was left and the thorax closed. Post operatively the baby was electively ventilated for three days. The chest drain produced 10 ml serous fluid in the first 24 hours but remained dry subsequently.

Conservative treatment includes keeping the child starved, or giving enteral medium chain triglycerides with or without intravenous alimentation. This treatment had failed in our baby. Initial misdiagnosis (as a leak) resulted in a delay of about 2 weeks in instituting aggressive conservative management of chylothorax. During this period the baby had lost weight. Components of usual surgical treatment are: treatment of the underlying cause, decreasing chyle production, draining and obliterating the pleural space, suture closure of thoracic duct or application of sealing agents, providing appropriate fluid and nutritional replacement, and instituting necessary respiratory care.

Surgical therapy is reserved for cases with persistent and/or high volume lymph leak that does not resolve within 4 weeks of conservative management. Various surgical procedures have been described including direct ligation of the thoracic duct [2, 3] pleurodesis with different agents including application of fibrin glue to putative sites of leaks [4] and placement of a pleuro-peritoneal shunt [5, 6]. Congenital chylothorax has been reported to be successfully treated by the application of fibrin glue [7].

Among all surgical options, application of fibrin glue appears to be an attractive approach in high risk cases like neonates. It is quick, safe, effective and easy for the novice. Its efficacy has been shown in postoperative chylothorax cases. Nguyen and Tchervenkov in 1994 have reported successful application of fibrin glue in a 600 gram premature neonate [8]. There are few reports in English literature on the use of fibrin glue for chylothorax in neonates as a complication of esophageal atresia repair. Rifai et al in 2003 successfully treated chylothorax in a post surgical case of esophageal atresia by a combination of argon beam coagulation of the mediastinum and fibrin glue application [9].