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Autoimmune Dis. 2012; 2012: 105205.
Published online Oct 2, 2012. doi:  10.1155/2012/105205
PMCID: PMC3467778
Aberrant Activation of Heat Shock Protein 60/65 Reactive T Cells in Patients with Behcet's Disease
Jun Shimizu, 1 Tomoko Izumi, 1 , 2 and Noboru Suzuki 1 *
1Department of Immunology and Medicine, St. Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-ku, Kawasaki 216-8511, Japan
2Department of Medicine, Self-Defense Forces Central Hospital, Tokyo 154-8532, Japan
*Noboru Suzuki: n3suzuki/at/marianna-u.ac.jp
Academic Editor: Kamal D. Moudgil
Received July 16, 2012; Accepted August 23, 2012.
Abstract
Behcet's disease (BD) is a multisystemic inflammatory disease and is characterized by recurrent attacks on eyes, brain, skin, and gut. There is evidence that skewed T-cell responses contributed to its pathophysiology in patients with BD. We found that heat shock proteins (HSPs) reactive T cells were prevalent in patients with BD. Here, we summarize current findings on HSP reactive T cells and their contribution to the pathogenesis in patients with BD.
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