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BMJ Open. 2012; 2(5): e000959.
Published online Sep 17, 2012. doi:  10.1136/bmjopen-2012-000959
PMCID: PMC3467590
Medication intensification in diabetes in rural primary care: a cluster-randomised effectiveness trial
Katherine L Billue,1 Monika M Safford,1 Amanda H Salanitro,2 Thomas K Houston,3,4 William Curry,1,5 Yongin Kim,1 Jeroan J Allison,4 and Carlos A Estrada1,5,6
1The University of Alabama at Birmingham, Birmingham, Alabama, USA
2VA Tennessee Valley Healthcare Geriatric Research, Education, Clinical Center (GRECC) and Vanderbilt University, Nashville, Tennessee, USA
3Bedford Veterans Affairs Medical Center, Beford, Massachusetts, USA
4The University of Massachusetts Medical School, Worcester, Massachusetts, USA
5Birmingham Veterans Affairs Medical Center, Birmingham, Alabama, USA
6Birmingham VAMC,Veterans Affairs National Quality Scholars Program, Birmingham, Alabama, USA
Correspondence to Dr Estrada; cestrada/at/uab.edu
Received March 15, 2012; Accepted August 17, 2012.
Abstract
Objective
To determine the effectiveness of a provider-based intervention to improve medication intensification among patients with diabetes.
Design
Effectiveness cluster-randomised trial. Baseline and follow-up cross-sections of diabetes physicians’ patients.
Setting
Eleven U.S. Southeastern states, 2006–2008.
Participants
205 Rural primary care physicians, 95 completed the study.
Intervention
Multicomponent interactive intervention including web-based continuing medical education (CME), performance feedback and quality improvement tools.
Primary outcome measures
Medication intensification, a dose increase of an existing medication or the addition of a new class of medication for glucose, blood pressure and lipids control on any of the three most recent office visits.
Results
Of 364 physicians attempting to register, 102 were randomised to the intervention and 103 to the control arms; 95 physicians (intervention, n=48; control, n=47) provided data on their 1182 of their patients at baseline (intervention, n=715; control, n=467) and 945 patients at follow-up (intervention, n=479; control, n=466). For A1c control, medication intensification increased in both groups (intervention, pre 26.4% vs post 32.6%, p=0.022; control, pre 24.8% vs post 31.1%, p=0.033) (intervention, adjusted OR (AOR) 1.37; 95% CI 1.06 to 1.76; control, AOR 1.41 (95% CI 1.06 to 1.89)); however, we observed no incremental benefit solely due to the intervention (group-by-time interaction, p=0.948). Among patients with the worst glucose control (A1c >9%), intensification increased in both groups (intervention, pre 34.8% vs post 62.5%, p=0.002; control, pre 35.7% vs post 61.4%, p=0.008).
Conclusions
A wide-reach, low-intensity, web-based interactive multicomponent intervention had no significant incremental effect on medication intensification for control of glucose, blood pressure or lipids for patients with diabetes of physicians practising in the rural Southeastern USA.
Trial registration
NCT00403091.
Keywords: Diabetes & Endocrinology, General Medicine (see Internal Medicine), Primary Care
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