Cancer is the second leading cause of death in New York City, with nearly 15,000 deaths each year. The urban setting of New York City provides ready access to large and diverse populations for whom racial/ethnic disparities in cancer risk and outcomes can be examined. A new cohort study was undertaken with several aims: (1) to provide a database and biorepository for studies of cancer etiology and pathogenesis, including host genetics; (2) to differentiate risk factors that contribute to racial/ethnic disparities in cancer risk, prevention, control, incidence, mortality, and survival; (3) to provide timely data on cancer risk and preventive behaviors that can be used to mobilize and then evaluate public health programs. Scientists from multiple institutions contributed to protocol design and implementation. Study instruments included demographics, personal and family history of cancer, risk and prevention efforts. End points include linkage with registries and medical record reviews. Using venue-based sampling with quotas, 18,187 adults aged 30 years or older were recruited over a year to undergo a baseline questionnaire, venipuncture, and contact information. The sample was 39% male, 37% older than 50 years, 58% white, 20% African American, 18% Hispanic, and 9% Asian. In terms of family history of cancer, 21% reported mother, 21% reported father, and 5.9% reported both parents with cancer; 8.5% reported any sibling with cancer. At baseline, 1,231 participants reported prior cancer. Showing the feasibility of constructing a cohort based in New York City, plans proceed for additional recruitment and analyses on the salient questions about cancer.
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1. Arias E, Smith BL. Deaths: preliminary data for 2001. Natl Vital Stat Rep. 2003;51:1–44.
2. Census Summary Tape, File 3A (STF3A) Washington, DC: US Dept of Commerce; 2000.
3. Govindarajan R, Shah RV, Erkman LG, Hutchins LF. Racial differences in the outcome of patients with colorectal carcinoma. Cancer. 2003;97:493–498. doi: 10.1002/cncr.11067. [PubMed] [Cross Ref] 4. Colditz GA, Manson JE, Hankinson SE. The Nurses Health Study: 20 year contribution to the understanding of health among women. J Women’s Health. 1997;6:49–62. doi: 10.1089/jwh.1997.6.49. [Cross Ref] 5. Cancer Prevention Study II The American Cancer Society Prospective Study. Stat Bull Metrop Insur Co. 1992;73:21–29. [PubMed] 6. Giovannucci E, Stampfer MJ, Colditz G, et al. Relationship of diet to risk of colorectal adenoma in men. J Natl Cancer Inst. 1992;84:91–98. [PubMed] 7. Brandt PA, Goldbohm RA, Veer P, et al. A large scale prospective cohort study on diet and cancer in the Netherlands. J Clin Epidemiol. 1990;43:285–295. doi: 10.1016/0895-4356(90)90009-E. [PubMed] [Cross Ref] 8. Bostick RM, Potter JD, Kushi LH, et al. Sugar, meat, and fat intake, and non-dietary risk factors for colon cancer incidence in Iowa women (United States) Cancer Causes Control. 1994;5:38–52. doi: 10.1007/BF01830725. [PubMed] [Cross Ref] 9. Gregersen PK, Felder E. Searching for gene-environment interactions in cancer: biorepository support for the New York Cancer Project. J Assoc Lab Automation. 2000;5:3–5. doi: 10.1016/S1535-5535(04)00092-9. [Cross Ref]
10. National Institutes of Health. Addressing health disparities: the NIH program of action. US. Department of Health and Human Services; 2002. Available at: http://healthdisparities.nih.gov/. Accessed November 18, 2002.
11. Andrulis DP. Inner City Health Care. Philadelphia, PA: American College of Physicians; 1997. The urban health penalty: new dimensions and directions in inner-city health care.
12. Calvert PM, Frucht H. The genetics of colorectal cancer. Ann Intern Med. 2002;137:603–612. [PubMed] 13. Gruber SB, Ellis NA, Rennart G, Offit K. BLM heterozygosity and the risk of colorectal cancer. Science. 2002;297:2013–2013. doi: 10.1126/science.1074399. [PubMed] [Cross Ref] 14. Foulkes WD, Thiffault I, Gruber SB, et al. The founder mutation MSH2*1906GC is an important cause of hereditary nonpolyposis colorectal cancer in the Ashkenazi Jewish population. Am J Hum Genet. 2002;71:1395–1412. doi: 10.1086/345075. [PubMed] [Cross Ref]
15. Vlahov D, Ahern J, Vazquez TL, Johnson S, Philips LA. Racial/ethnic disparities in colon cancer screening in New York City: independent of socioeconomic status, health insurance, smoking and family history. Paper presented at: Society for Epidemiologic Research meeting; June 2003; Atlanta, GA.
16. Vlahov D, Ahern J, Vazquez TL, Johnson S, Philips L, Galea S. Racial/ethnic disparities in cancer screening rates in the New York City metropolitan area. Paper presented at: American Public Health Association meeting; November 2003; San Francisco, CA.
17. New York City Department of Health and Mental Hygiene. Health alert: colonoscopy to prevent colon cancer. February/March 2003;2(2). Available at: http://www.ci.nyc.ny.us/html/doh/html/pub/pub.html. Accessed May 1, 2003.