1. Fugelstad A, Annell A, Rajs J, Angren G. Mortality and causes and manner of death among drug addicts in Stockholm during the period 1981–1992. Acta Psychiatr Scand. 1997;96:169–175. [PubMed] 2. Goldstein A, Herrara J. Heroin addicts and methadone treatment in Albuquerque: a 22-year follow-up. Drug Alcohol Depend. 1995;40:139–150. doi: 10.1016/0376-8716(95)01205-2. [PubMed] [Cross Ref] 3. Oppenheimer E, Tobutt C, Taylor C, Andrew T. Death and survival in a cohort of heroin addicts from London clinics: a 22 year follow-up. Addiction. 1994;89:1299–1308. doi: 10.1111/j.1360-0443.1994.tb03309.x. [PubMed] [Cross Ref] 4. Quaglio G, Talamini G, Lechi A, Venturini L, Lugoboni F, Mezzelani P. Study of 2708 heroin-related deaths in north-eastern Italy 1985–98 to establish main causes of death. Addiction. 2001;96:1127–1137. doi: 10.1046/j.1360-0443.2001.96811276.x. [PubMed] [Cross Ref] 5. Sanchez-Carbonell X, Seus L. Ten year survival analysis of a cohort of heroin addicts in Catalonia: the EMETYST project. Addiction. 2000;95:941–948. doi: 10.1046/j.1360-0443.2000.95694110.x. [PubMed] [Cross Ref] 6. Darke S, Zador D. Fatal heroin overdose: a review. Addiction. 1996;91:1765–1772. doi: 10.1111/j.1360-0443.1996.tb03800.x. [PubMed] [Cross Ref] 7. Sporer K. Acute heroin overdose. Ann Int Med. 1999;130:584–590. [PubMed] 8. Warner-Smith M, Darke S, Lynskey M, Hall W. Heroin overdose: causes and consequences. Addiction. 2001;96:1113–1125. doi: 10.1046/j.1360-0443.2001.96811135.x. [PubMed] [Cross Ref] 9. Centers for Disease Control Heroin overdose deaths—Multnomah County, Oregon, 1993–1999. MMWR Morb Mortal Wkly Rep. 2000;49:633–636. [PubMed] 10. Centers for Disease Control Unintentional opiate overdose deaths—Kings County, Washington, 1990–1999. MMWR Morb Mortal Wkly Rep. 2000;49:636–640. [PubMed] 11. Ochoa KC, Hahn JA, Seal KH, Moss AR. Overdosing among young injection drug users in San Francisco. Addict Behav. 2001;26:453–460. doi: 10.1016/S0306-4603(00)00115-5. [PubMed] [Cross Ref] 12. O’Driscoll PT, McGough J, Hagan H, Thiede H, Critchlow C, Russell AE. Predictors of accidental fatal drug overdose among a cohort of injection drug users. Am J Public Health. 2001;26:984–987.
13. Hall W, Degenhardt L, Lynskey M. Trends in opioid overdose and suicide mortality in young adults in Australia 1964–1997. Med J Aust. 1999;171:34–37. [PubMed] 14. Bennett G, Higgins D. Accidental overdose among injecting drug users in Dorset, UK. Addiction. 1999;94:1179–1190. doi: 10.1046/j.1360-0443.1999.94811798.x. [PubMed] [Cross Ref] 15. Darke S, Ross J, Hall W. Overdose among heroin users in Sydney, Australia. I. Prevalence and correlates of non-fatal overdose. Addiction. 1996;91:405–411. doi: 10.1111/j.1360-0443.1996.tb02289.x. [PubMed] [Cross Ref] 16. Darke S, Ross J. Overdose risk perceptions and behaviours among heroin users in Sydney, Australia. Eur Addict Res. 1997;3:87–92.
17. Gossop M, Griffiths P, Powis B, Williamson S, Strang J. Frequency of non-fatal heroin overdose: survey of heroin users recruited in non-clinical settings. BMJ. 1996;313:402–402. [PMC free article] [PubMed] 18. McGregor C, Darke S, Christie P, Ali R. Experience of non-fatal overdose among heroin users in Adelaide: circumstances and risk perception. Addiction. 1998;93:701–711. doi: 10.1046/j.1360-0443.1998.9357016.x. [PubMed] [Cross Ref] 19. Swift W, Maher L, Sunjic S. Transitions between routes of heroin administration: a study of Caucasian and Indochinese heroin users in south-western Sydney, Australia. Addiction. 1999;94:71–82. doi: 10.1046/j.1360-0443.1999.941714.x. [PubMed] [Cross Ref] 20. Darke S, Sims J, McDonald S, Wickes W. Cognitive impairment among methadone maintenance patients. Addiction. 2000;95:687–695. doi: 10.1046/j.1360-0443.2000.9556874.x. [PubMed] [Cross Ref] 21. Cherubin C, McCusker J, Baden M, Kavaler F, Amsel Z. The epidemiology of death in narcotic addicts. Am J Epidemiol. 1972;96:11–22. [PubMed] 22. Darke S, Ross J, Zador D, Sunjic S. Heroin-related deaths in New South Wales, Australia, 1992–1996. Drug Alcohol Depend. 2000;60:141–150. doi: 10.1016/S0376-8716(99)00147-7. [PubMed] [Cross Ref] 23. Frischer M, Bloor M, Goldberg D, Clark J, Green S, McKegany N. Mortality among injecting drug users: a critical reappraisal. J Epidemiol Community Health. 1993;47:59–63. doi: 10.1136/jech.47.1.59. [PMC free article] [PubMed] [Cross Ref] 24. Hall W, Darke S. Trends in opiate overdose deaths in Australia, 1979–1995. Drug Alcohol Depend. 1998;52:71–77. doi: 10.1016/S0376-8716(98)00044-1. [PubMed] [Cross Ref] 25. McGregor C, Ali R, Lokan R, Christie P, Darke S. Accidental fatalities among heroin users in South Australia, 1994–1997: toxicological findings and circumstances of death. Addict Res. 2002;26:335–346. doi: 10.1080/1606635021000010261. [Cross Ref] 26. Zador D, Sunjic S, Darke S. Heroin-related deaths in New South Wales, 1992: toxicological findings and circumstances. Med J Aust. 1996;164:204–207. [PubMed] 27. Harlow KC. Patterns of rates of mortality from narcotics and cocaine overdose in Texas, 1976–1987. Public Health Rep. 1990;195:455–462. [PMC free article] [PubMed] 28. Ruttenber AJ, Luke JL. Heroin-related deaths: new epidemiologic insights. Science. 1984;226:14–20. [PubMed] 29. Caplehorn JRM, Dalton SYN, Cluff MC, Petrenas AM. Retention in methadone maintenance and heroin addicts’ risk of death. Addiction. 1994;89:203–207. doi: 10.1111/j.1360-0443.1994.tb00879.x. [PubMed] [Cross Ref] 30. Davoli M, Perucci CA, Forastiere F, et al. Risk factors for overdose mortality: a case control study within a cohort of intravenous drug users. Int J Epidemiol. 1993;22:273–277. [PubMed] 31. Fugelstad A, Rajs J, DeVerdier MG. Mortality among HIV-infected intravenous drug addicts in Stockholm in relation to methadone treatment. Addiction. 1995;90:711–716. doi: 10.1111/j.1360-0443.1995.tb02209.x. [PubMed] [Cross Ref] 32. Stewart D, Gossop M, Marsden J. Reductions in non-fatal overdose after drug misuse treatment: results from the National Treatment Outcome Research Study (NTORS) J Subst Abuse Treat. 2002;22:1–9. doi: 10.1016/S0740-5472(01)00206-9. [PubMed] [Cross Ref] 33. Goldberger BA, Cone EJ, Grant TM, Caplan YH, Levine BS, Smialek JE. Disposition of heroin and its metabolites in heroin related deaths. J Anal Toxicol. 1994;18:22–28. [PubMed] 34. Monforte JR. Some observations concerning blood morphine concentrations in narcotic addicts. J Forensic Sci. 1977;22:718–724. [PubMed] 35. Risser D, Honigschnabl S, Stichenwirth M, et al. Drug-related emergencies and drug-related deaths in Vienna, 1995–1997. Drug Alcohol Depend. 2001;61:307–313. doi: 10.1016/S0376-8716(00)00150-2. [PubMed] [Cross Ref] 36. Steentoft A, Worm K, Christenson H. Morphine concentrations in autopsy material from fatal cases after intake of morphine and/or heroin. J Forensic Sci Soc. 1988;28:87–94. doi: 10.1016/S0015-7368(88)72812-1. [PubMed] [Cross Ref] 37. Gutierrez-Cebollada J, Torre R, Ortuno J, Garces J, Cami J. Psychotropic drug consumption and other factors associated with heroin overdose. Drug Alcohol Depend. 1994;35:169–174. doi: 10.1016/0376-8716(94)90124-4. [PubMed] [Cross Ref] 38. Ruttenber AJ, Kalter HO, Santinga P. The role of ethanol abuse in the etiology of heroin-related death. J Forensic Sci. 1990;35:891–900. [PubMed] 39. Caplehorn J. Risk factors for non-HIV-related deaths among methadone maintenance patients. Eur Addict Res. 1996;2:49–52.
40. Richards RG, Reed D, Cravey RH. Death from intravenously administered narcotics: a study of 114 cases. J Forensic Sci. 1976;21:467–482. [PubMed] 41. Darke S, Ross J. The use of antidepressants among injecting drug users in Sydney, Australia. Addiction. 2000;95:407–417. doi: 10.1046/j.1360-0443.2000.95340711.x. [PubMed] [Cross Ref] 42. Darke S, Hall W, Weatherburn D, Lind B. Fluctuations in heroin purity and the incidence of fatal heroin overdose. Drug Alcohol Depend. 1999;54:155–161. doi: 10.1016/S0376-8716(98)00159-8. [PubMed] [Cross Ref] 43. Desmond DP, Maddux JF, Trevino A. Street heroin potency and deaths from overdose in San Antonio. Am J Drug Alcohol Abuse. 1978;5:39–49. [PubMed] 44. Risser D, Uhl A, Stichenwirth M, et al. Quality of heroin and heroin-related deaths from 1987 to 1995 in Vienna, Austria. Addiction. 2000;95:375–382. doi: 10.1046/j.1360-0443.2000.9533758.x. [PubMed] [Cross Ref] 45. Coomber R. How often does the adulteration/dilution of heroin actually occur? An analysis of 228 “street” heroin samples across the UK (1995–96) and discussion of monitoring policy. Int J Durg Policy. 1997;8:178–186.
46. Coomber R. The cutting of heroin in the United States in the 1990s. J Drug Issues. 1999;29:17–36.
47. Maher L, Swift W, Dawson M. Heroin purity and composition in Sydney, Australia. Drug Alcohol Rev. 2001;20:439–448. doi: 10.1080/09595230120092698. [Cross Ref] 48. Darke S, Sunjic S, Zador D, Prolov T. A comparison of blood toxicology of heroin-related deaths and current heroin users in Sydney, Australia. Drug Alcohol Depend. 1997;47:45–53. doi: 10.1016/S0376-8716(97)00070-7. [PubMed] [Cross Ref] 49. Kintz P, Mangin P, Lugnier AA, Chaumont AJ. Toxicological data after heroin overdose. Hum Toxicol. 1989;8:487–489. doi: 10.1177/096032718900800609. [PubMed] [Cross Ref] 50. Darke S, Hall W, Kaye S, Ross J, Duflou J. Hair morphine concentrations of fatal heroin overdose cases and living heroin users. Addiction. 2002;97:977–984. doi: 10.1046/j.1360-0443.2002.00148.x. [PubMed] [Cross Ref] 51. Tagliaro F, Debattisti Z, Smith FP, Marigo M. Death from heroin overdose: findings from hair analysis. Lancet. 1998;351:1923–1925. doi: 10.1016/S0140-6736(97)10101-5. [PubMed] [Cross Ref] 52. Kronstrand R, Grundin R, Jonsson J. Incidence of opiates, amphetamines, and cocaine in hair and blood in fatal cases of heroin overdose. Forensic Sci Int. 1998;92:29–38. doi: 10.1016/S0379-0738(98)00003-6. [PubMed] [Cross Ref] 53. Darke S, Kaye S, Finlay-Jones R. Drug use and injection risk-taking among prison methadone maintenance patients. Addiction. 1998;93:1169–1175. doi: 10.1046/j.1360-0443.1998.93811695.x. [PubMed] [Cross Ref] 54. Seaman SR, Brettle RP, Gore SM. Mortality from overdose among injecting drug users recently released from prison: database linkage study. BMJ. 1998;316:426–428. [PMC free article] [PubMed] 55. Seymour A, Oliver JS, Black M. Drug-related deaths among recently released prisoners in the Strathelyde region of Scotland. J Forensic Sci. 2000;45:649–654. [PubMed] 56. Strang J, Griffiths P, Powis B, Gossop M. Heroin chasers and heroin injectors: differences observed in a community sample in London, UK. Am J Addict. 1999;8:148–160. doi: 10.1080/105504999305956. [PubMed] [Cross Ref] 57. Neaigus A, Miller M, Friedman S, et al. Potential risk factors for the transition to injecting among non-injecting heroin users: a comparison of former injectors and never injectors. Addiction. 2001;96:847–860. doi: 10.1046/j.1360-0443.2001.9668476.x. [PubMed] [Cross Ref] 58. Perez-Jimenez JP, Robert MS. Transitions in the route of heroin use. Eur Addict Res. 1997;3:93–98. doi: 10.1159/000259157. [Cross Ref] 59. Darke S, Ross J. Fatal heroin overdoses resulting from non-injecting routes of administration, NSW, Australia, 1992–1996. Addiction. 2000;95:596–599.
60. Dinwiddie SH, Reich T, Cloninger CR. Psychiatric comorbidity and suicidality among intravenous drug users. J Clin Psychiatry. 1992;53:364–369. [PubMed] 61. Darke S, Ross J. Poly drug dependence and psychiatric comorbidity among heroin injectors. Drug Alcohol Depend. 1997;48:135–141. doi: 10.1016/S0376-8716(97)00117-8. [PubMed] [Cross Ref] 62. Kosten TR, Rounsaville BJ. Suicidality among opioid addicts: a 2.5 year follow-up. Am J Drug Alcohol Abuse. 1998;14:357–369. [PubMed] 63. Hulse GK, English DR, Milne E, Holman CDJ. The quantification of mortality resulting from the regular use of illicit opiates. Addiction. 1999;94:221–229. doi: 10.1046/j.1360-0443.1999.9422216.x. [PubMed] [Cross Ref] 64. Neale J. Suicidal intent in non-fatal illicit drug overdose. Addiction. 2000;95:85–93. doi: 10.1046/j.1360-0443.2000.951859.x. [PubMed] [Cross Ref] 65. Rossow I, Lauritzen G. Balancing on the edge of death: suicide attempts and life-threatening overdoses among drug addicts. Addiction. 1999;94:209–219. doi: 10.1046/j.1360-0443.1999.9422095.x. [PubMed] [Cross Ref] 66. Darke S, Ross J. The relationship between suicide and overdose among methadone maintenance patients in Sydney, Australia. Addiction. 2001;96:1443–1453. doi: 10.1046/j.1360-0443.2001.961014438.x. [PubMed] [Cross Ref] 67. Kjelsberg E, Winther M, Dahl AA. Overdose deaths in young substance abusers: accidents or hidden suicides. Acta Psychiatr Scand. 1995;91:236–242. [PubMed] 68. Darke S, Ross J. Suicide among heroin users: rates, risk factors and methods. Addiction. 2002;97:1383–1394. doi: 10.1046/j.1360-0443.2002.00214.x. [PubMed] [Cross Ref] 69. Darke S, Ross J, Hall W. Overdose among heroin users in Sydney, Australia. II. Responses to overdose. Addiction. 1996;91:413–417. doi: 10.1111/j.1360-0443.1996.tb02290.x. [PubMed] [Cross Ref] 70. Strang J, Best D, Man L, Noble A, Gossop M. Peer-initiated overdose resuscitation: fellow drug users could be mobilised to implement resuscitation. Int J Drug Policy. 2000;11:437–445. doi: 10.1016/S0955-3959(00)00070-0. [PubMed] [Cross Ref] 71. Manning FJ, Ingraham LH, Derouin EM, Vaughn MS, Kukura FC, St Michel GR. Drug “overdoses” among US soldiers in Europe, 1978–1979. II. Psychological autopsies following deaths and near-deaths. Int J Addict. 1983;18:153–156. [PubMed] 72. Garriot JC, Sturner WQ. Morphine concentrations and survival periods in acute heroin fatalities. N Engl J Med. 1973;289:1276–1278. doi: 10.1056/NEJM197312132892404. [PubMed] [Cross Ref] 73. Nakamura GR. Toxicological assessments in acute heroin fatalities. Clin Toxicol. 1978;13:75–87. doi: 10.3109/15563657808988229. [PubMed] [Cross Ref] 74. Bammer G, Sengoz A. Non-fatal heroin overdoses. Med J Aust. 1994;161:572–573. [PubMed] 75. McGregor C, Ali R, Christie P, Darke S. Overdose among heroin users: evaluation of an intervention in South Australia. Addict Res. 2001;9:481–501.
76. Darke S, Hall W. The distribution of naloxone to heroin users. Addiction. 1997;92:1195–1199. doi: 10.1111/j.1360-0443.1997.tb03681.x. [PubMed] [Cross Ref] 77. Lenton S, Hargreaves K. Should we conduct a trial of distributing naloxone to heroin users for peer administration to prevent fatal overdose? Med J Aust. 2000;173:260–263. [PubMed] 78. Strang J, Darke S, Hall W, Farrell M, Ali R. Heroin overdose: is there a case for takehome naloxone? BMJ. 1996;312:1435–1435. [PMC free article] [PubMed] 79. Hunt N, Griffiths P, Southwell M, Stillwell G, Strang J. Proventing and curtailing injecting drug use: a review of opportunities for developing and delivering “route transition interventions” Drug Alcohol Rev. 1999;18:441–445. doi: 10.1080/09595239996310. [Cross Ref] 80. Dolan K, Kimber J, Fry C, Fitzgerald J, McDonald D, Trautmann F. Drug consumption facilities in Europe and the establishment of supervised injecting centres in Australia. Drug Alcohol Rev. 2000;337–346.
81. Kemmesies UE. The Open Drug Scene and the Safe Injection Rooms Offers in Frankfurt am Main 1995. Frankfurt, Germany: Stadt Frankfurt/Dezernat Frauen und Gesundheit; 1999.
82. Poschadel S, Hoger R, Schnitzler J, Schreckenberg D. Evaluation der Arbeit der Drogenkonsumraume in der Bundesrepublik Deutschland. Bochum, Germany: ZEUS GmbH; 2002.
83. Ronco C, Spuhler G, Coda P, Schopfer R. Evaluation for alley-rooms I, II and II in Basel. Soc Prev Med. 1996;S58–S68.
84. Rehm J, Gschwend P, Steffen T, Gutzwiller F, Dobler-Mikola A, Uchtenhagen A. Feasibility, safety, and efficacy of injectable heroin prescription. Lancet. 2001;358:1417–1420. doi: 10.1016/S0140-6736(01)06529-1. [PubMed] [Cross Ref] 85. Hall W. Assessing the Population-Level Impact of the Swiss Model of Heroin Prescribing. Sydney, Australia: University of New South Wales, Sydney; 1999.
86. Warner-Smith M, Darke S, Day C. Morbidity associated with non-fatal heroin overdose. Addiction. 2002;97:963–967. doi: 10.1046/j.1360-0443.2002.00132.x. [PubMed] [Cross Ref]