Search tips
Search criteria 


Logo of jargspringer.comThis journalToc AlertsSubmit OnlineOpen Choice
J Assist Reprod Genet. 2000 November; 17(10): 547–552.
PMCID: PMC3455453

Does Body Mass Index of Infertile Women Have an Impact on IVF Procedure and Outcome?


Purpose: The objective was to explore whether body mass index (BMI) of women related to the different parameters of the in vitro fertilization (IVF) procedure and outcome.

Methods: This retrospective study on 398 couples analyzed epidemiological features, characteristics of ovarian stimulation, number and quality of retrieved oocytes, as well as pregnancy outcome according to three groups of BMI values: BMI < 20, 20 ≤ BMI < 25 and BMI ≥ 25 kg/m2.

Results: The prevalence of underweight and overweight women was 21.8% and 22.3%, respectively. The mean ratio follicle-stimulating hormone–luteinizing hormone increased significantly according to BMI. An increase in the mean number of consummated gonadotropin ampoules together with a decrease in the number of collected oocytes was observed in long stimulation protocol cycles when BMI ≥ 25 kg/m2. The same observations were made in short stimulation protocol cycles for BMI < 20 and ≥ 25 kg/m2. No significant difference could be found in clinical pregnancy and miscarriage rates between underweight, normal weight, and overweight patients.

Conclusions: Both underweight and overweight have negative effects on IVF parameters and outcome leading to decreased chances of pregnancy.

Keywords: body mass index, intracytoplasmic sperm injection, in vitro fertilization, obesity

Full Text

The Full Text of this article is available as a PDF (68K).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
1. Green BB, Weiss NS, Daling JR. Risk of ovulatory infertility in relation to body weight. Fertil Steril. 1988;50:721–726. [PubMed]
2. Zaadstra BM, Seidell JC, Van Noord PAH, Tevelde ER, Habbema JDF, Vrieswijk B, Karbaat J. Fat and female fecundity: Prospective study of effect of body fat distribution on conception rates. Br Med J. 1993;306:484–487. [PMC free article] [PubMed]
3. Grodstein F, Goldman M, Cramer D. Body mass index and ovulatory infertility. Epidemiology. 1994;5:247–250. [PubMed]
4. Déchaud H, Ferron G, Anahory T, Arnal F, Humeau C, Hédon B. Obésité et assistance mé dicale á la procréation. Contracept Fertil Sex. 1998;26:564–567. [PubMed]
5. Clark AM, Thorley B, Tomlinson L, Galletley C, Norman RJ. Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment. Hum Reprod. 1998;13:1502–1505. [PubMed]
6. Brost BC, Goldenberg RL, Mercer BM, Iams JD, Meis PJ, Moawad AH, Newman RB, Miodovnik M, Caritis SN, Thurnau GR, Bottoms SF, Das A, McNellis D. The preterm prediction study: Association of cesarean delivery with increases in maternal weight and body mass index. Am J Obstet Gynecol. 1997;177:333–341. [PubMed]
7. Crosignani PG, Ragni G, Parazzini F, Wyssling H, Lombroso G, Perotti L. Anthropometric indicators and response to gonadotrophin for ovulation induction. Hum Reprod. 1994;9:420–423. [PubMed]
8. Zullo F, Di Carlo C, Pellicano M, Catizone C, Mastrantonio P, Nappi C. Superovulation with urinary human follicle-stimulating hormone: Correlations with body mass index and body fat distribution. Gynecol Endocrinol. 1996;10:17–21. [PubMed]
9. Lewis CG, Warnes GM, Wang X, Matthews CD. Failure of body mass index or body weight to influence markedly the response to ovarian stimulation in normal cycling women. Fertil Steril. 1990;53:1097–1099. [PubMed]
10. Veeck L. Atlas of the Human Oocyte and Early Conceptus (Vol. 2) Baltimore: Williams & Wilkins; 1991.
11. Van Steirteghem A, Nagy Z, Joris H, Liu J, Staessen C, Smitz J, Wisanto A, Devroey P. High fertilization and implantation rates after intracytoplasmic sperm injection. Hum Reprod. 1993;8:1061–1066. [PubMed]
12. Lashen H, Ledger W, Lopez Bernal A, Barlow D. Extremes of body mass do not adversely affect the outcome of superovulation and in-vitro fertilization. Hum Reprod. 1999;14:712–715. [PubMed]
13. Singh KB, Mahajan DK, Wortsman J. Effect of obesity on the clinical and hormonal characteristics of the polycystic ovary syndrome. J Reprod Med. 1994;39:805–808. [PubMed]
14. Galtier-Dereure F, Pujol P, Dewailly D, Bringer J. Choice of stimulation in polycystic ovarian syndrome: The influence of obesity. Hum Reprod. 1997;13(Suppl1):88–96. [PubMed]
15. Mukherjee T, Copperman AB, Lapinski R, Sandler B, Bustillo M, Grunfeld L. An elevated day three follicle-stimulating hormone: luteinizing hormone ratio (FSH/LH) in the presence of a normal day 3 FSH predicts a poor response to controlled ovarian hyperstimulation. Fertil Steril. 1996;65:588–593. [PubMed]
16. Shepard MK, Balmaceda JP, Lelia CG. Relationship of weight to successful induction of ovulation with clomiphene citrate. Fertil Steril. 1979;32:641–645. [PubMed]
17. Dickey RP, Taylor SN, Curole DN, Rye PH, Lu PY, Pyrzak R. Relationship of clomiphene dose and patient weight to successful treatment. Hum Reprod. 1997;12:449–453. [PubMed]
18. Wass P, Waldenström U, Rössner S, Hellberg D. An android body fat distribution in females impairs the pregnancy rate of in-vitro fertilization-embryo transfer. Hum Reprod. 1997;12:2057–2060. [PubMed]
19. Bray GA. Obesity and reproduction. Hum Reprod. 1997;12(Suppl.1):26–32. [PubMed]

Articles from Journal of Assisted Reproduction and Genetics are provided here courtesy of Springer Science+Business Media, LLC