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J Headache Pain. Apr 2005; 6(2): 81–87.
Published online Apr 8, 2005. doi:  10.1007/s10194-005-0156-3
PMCID: PMC3452313
Managing migraine headaches experienced by patients who self–report with menstrually related migraine: a prospective, placebo–controlled study with oral sumatriptan
A. J. Dowson,corresponding author1 H. Massiou,2 and S. K. Aurora3
1The King’s Headache Service, King’s College Hospital, Denmark Hill, London SE5 9RS, UK
2Department of Neurology, Hospital Lariboisiere, Paris, France
3Swedish Headache Center and Neurosciences Institute, Seattle, WA USA
A. J. Dowson, Phone: +44-1428-712546, Fax: +44-1428-712546, andydowson/at/
corresponding authorCorresponding author.
Received October 25, 2004; Accepted February 16, 2005.
The objective was to evaluate the efficacy and tolerability of oral sumatriptan (100 mg) in patients who self–reported with menstrually related migraine. A prospective, multicentre, randomised, double–blind, placebocontrolled, two–group crossover study was carried out in 20 UK primary and secondary care surgeries. Of 115 patients with a self–reported history of menstrually related migraine that entered the study, 93 patients completed it. Patients treated all migraine attacks for 2 months with sumatriptan (100 mg) and for 2 months with placebo. The primary endpoint was the proportion of patients reporting headache relief at 4 hours for the first treated attack. Only 11% of patients fulfilled the protocol definition of menstrually related migraine. Patients reported a variable pattern of migraine attacks occurring inside and outside the menstrual window. For the first attack, significantly more patients receiving sumatriptan than placebo reported headache relief for attacks occurring inside (67% vs. 33%, p=0.007) and outside (79% vs. 31%, p<0.001) the menstrual period. Sumatriptan was generally well tolerated. Oral sumatriptan (100 mg) is an effective and well tolerated acute treatment for patients who report menstrually related migraine.
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