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Logo of bmcophtBioMed Centralsearchsubmit a manuscriptregisterthis articleBMC Ophthalmology
BMC Ophthalmol. 2012; 12: 8.
Published online May 15, 2012. doi:  10.1186/1471-2415-12-8
PMCID: PMC3444890
Retro-mode imaging and fundus autofluorescence with scanning laser ophthalmoscope of retinal dystrophies
Battaglia Parodi Maurizio,1 Iacono Pierluigi,corresponding author2 Kontadakis Stelios,1 Vergallo Stefano,3 Cascavilla Marialucia,1 Zucchiatti Ilaria,1 and Bandello Francesco1
1Department of Ophthalmology, Vita-Salute University, San Raffaele Scientific Institute, Milan, Italy
2G. B. Bietti Foundation, IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Rome, Italy
3Clinica Oculistica, Santa Maria della Misericordia Hospital, Udine, Italy
corresponding authorCorresponding author.
Battaglia Parodi Maurizio: maubp/at/; Iacono Pierluigi: pierluigi.iacono/at/; Kontadakis Stelios: kontadoskriti/at/; Vergallo Stefano: vergallo/at/; Cascavilla Marialucia: marialuciacascavilla/at/; Zucchiatti Ilaria: ilaria.zucchiatti/at/; Bandello Francesco: bandello.francesco/at/
Received March 16, 2011; Accepted March 19, 2012.
Retinal dystrophies display a considerably wide range of phenotypic variability, which can make diagnosis and clinical staging difficult. The aim of the study is to analyze the contribution of retro-mode imaging (RMI) and fundus autofluorescence (FAF) to the characterization of retinal dystrophies.
Eighteen consecutive patients affected by retinal dystrophies underwent a complete ophthalmological examination, including best corrected visual acuity with ETDRS charts, blue-light fundus autofluorescence, (BL-FAF), near-infrared fundus autofluorescence (NIR-FAF), and RMI. The primary outcome was the identification of abnormal patterns on RMI. The secondary outcome was the correlation with the findings on BL-FAF and NIR-FAF.
Overall, the main feature of RMI is represented by a pseudo-3D pattern of all the lesions at the posterior pole. More specifically, any accumulation of material within the retina appears as an area of elevation of different shape and size, displaying irregular and darker borders. No precise correlations between RMI, BL-AF, and NIR-AF imaging was found.
RMI and FAF appear to be useful tools for characterizing retinal dystrophies. Non-invasive diagnostic tools may yield additional information on the clinical setting and the monitoring of the patients.
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