Routine history taking begins with a set of standard questions that will elicit basic information and, depending on the acuity of onset, the age of the patient and whether he/she presents to you in the office/consulting room or emergency department/casualty, you will need to elicit additional history. In every headache patient, our worry and the patients fear is that no serious life-threatening cause should be overlooked. It is therefore important to keep in mind the “red flags” and ask the right questions to be able to decide whether the patient could be having a serious secondary headache warranting further investigation. Any new onset headache or anything that is atypical for a particular type of primary headache should get you worried about the presence of a secondary headache and warrant imaging. “Red flags” that should caution you to be careful and investigate further are listed in .[5
The questions can flow in the following preset fashion:
Since how long have you been having headaches?
This will tell us about the onset and the duration of the headache. It is useful to divide this into two phases: (i) an immediate phase of increased frequency or severity for which the patient has now come for consultation and (ii) an earlier phase of lesser frequency or severity. This will help determine if this is definitely a NEW onset headache or something that has been there since before and has worsened now. You are sometimes surprised by patients who half-way through the history tell you, “Oh, I have always had these normal headaches since childhood!” This could mean an earlier mild migraine that has been there and that has now worsened. New onset headaches should always be taken seriously. The longer the time for which the headaches have been present, the greater the likelihood of the headache being a primary headache. If there is an acute onset, severe, first and worst headache, the common possibilities are sub-arachnoid hemorrhage, vascular dissection, cerebral venous thrombosis, reversible cerebral vasoconstriction syndrome, acute hypertensive crisis or a primary thunderclap headache. Rarely pituitary apoplexy, colloid cyst, sphenoid sinusitis or spontaneous intracranial hypotension may present with acute onset headache.
Where in the head does it pain and how does it radiate?
This will tell us about the location and the pattern of radiation. It could be unilateral to begin with and then become generalized, which is what would be seen with a migraine headache, or it could be holocranial, generalized as with tension-type headache or it could start periorbitally as with cluster headache. Migraine headaches are usually in the temporal region, over the vertex, in the occipital region and often radiate to the neck on the same side as the pain. They often alternate sides but can rarely remain side-locked. Side-locked headaches warrant investigation to rule out an underlying structural cause. Cluster headache is classically side-locked and is mostly periorbital to start with and may then spread to becoming hemicranial. Because of an overlapping nerve supply, periorbital headaches can have many causes.
Patients with headache who also complain of neck, shoulder or arm pain should be investigated to rule out cervicogenic headache, although 75% of migraine patients can have associated neck pain.[6
] Due to an overlapping nerve supply and referral and convergence patterns, pain can also be referred to distant locations. Supratentorial structures are innervated by the ophthalmic division of the fifth cranial nerve and the posterior fossa structures are supplied by C2 and C3. Therefore, pain from the upper cervical spine or posterior fossa can be referred anteriorly to the front of the head.
Facial pain has many underlying causes, of which trigeminal neuralgia is the most common. When a patient presents with facial pain, you need to consider the neuralgias, facial pain syndromes involving the cranial nerves, the trigemino-autonomic cephalgias (TACs), rhinologic conditions, dental disorders, temporomandibular problems and idiopathic facial pain. In addition to the questions listed, it is very important to ask for cutaneous triggers for the facial pain as with trigeminal neuralgia
How often does the head pain?
This will tell you about the frequency and whether it is a monthly, weekly or daily headache. If it is a daily or near-daily headache, is it only once a day or more than once per day. Ask if it was less earlier and more frequent now, if the pain comes on at any particular time of the day, if it has a diurnal variation, if it is more at night than in the day, if it wakes up the patient from sleep or if it is present on awakening. Some headaches that are more likely to present with headache at night are hypnic headache syndrome, cluster headache, SUNCT syndrome or exploding head syndrome. With headache present on awakening in the morning, one has to suspect obstructive sleep apnea, poorly controlled hypertension, raised intracranial pressure or migraine. Ask for any fixed seasonal pattern, whether it comes on only during certain times of the year, with periods of spontaneous remission as with cluster headache, or whether there is a cyclic pattern as with cyclic migraine. A progressively worsening frequency or a headache that is unresponsive to treatment indicates a secondary cause.
How long does each attack last? Is it short-lasting or long-lasting?
It is important to ascertain if it is a short-lasting headache or long-lasting headache. An arbitrary duration of 4 hours is considered as the cut-off between short-lasting and long-lasting headache. The trigemino-autonomic cephalgias (TACs) such as cluster headache and chronic paroxysmal hemicrania (CPH) are examples of short-lasting headaches that usually last for under 4 hours. Primary stabbing headaches are very brief and can last from 10 secs to a minute. Likewise, trigeminal neuralgia attacks are lightening stabs of pain that are of also very brief duration, usually a few seconds, as are headaches due to the SUNCT syndrome, which is another example of a TAC. Migraine headaches on the other hand are of longer duration and last anywhere from 4 to 72 h.
How severe is the pain?
This will tell us about the severity. S everity of the pain can be subjectively gauged on the verbal rating scale from 0 to 10, where 0 refers to no pain and 10 is the worst pain. Cluster headache and moderate to severe migraine are usually described as a 9/10 or 10/10 severity pain as compared with tension-type headache, which is usually a 3–5/10 severity pain. It is necessary to emphasise here that severity of the head pain does not tell us whether we are dealing with a primary or secondary headache. The pain of migraine or cluster headache can be just as severe and disabling as that due to a sub-arachnoid hemorrhage.
What type of pain is it? What is the Nature of the pain?
Although not always a useful pointer, most headaches that are pulsatile or throbbing or hammering in nature are usually due to migraine. The other strikingly different short-lasting pains are the ice pick pains. Tension-type headache is a dull featureless pain with no accompaniments. Ask if the headache builds up gradually as with migraine or does it peak rapidly as with the TACs.
What factors can precipitate or worsen the headache. Are there any triggering or relieving factors?
This will tell you if there are any trigger factors – environmental, dietary, hormonal. Because a common disorder like migraine is influenced by so many trigger factors that vary across regions and cultures, it is essential to be aware of these when taking the history.
Ask if there is any link with the menstrual cycle which would suggest the possibility of migraine, a seasonal link suggestive of cluster headache or if movement or activity worsens the headache. Relieving factors are also important. If there is any increase or reduction with lying down, or postural worsening, it should suggest an alteration in cerebrospinal fluid dynamics.
Are there any accompaniments to the head pain?
Vomiting can be a feature of migraine or an intracranial disorder, but hypersensitivity phenomena such as photophobia, phonophobia or osmophobia are often seen only with migraine. These can rarely be present with subarachnoid hemorrhage or meningitis. Autonomic features such as lacrimation or rhinorrhea are usually seen with the TACs. Ask if the eye becomes small (ptosis) or if the eye becomes red or swollen. These are features of Horner's syndrome and indicate the possibility of TACs. Pulsating, throbbing temporal vessels are seen with migraine. A tender painful superficial temporal artery can occur with giant cell arteritis. Syncope in a headache patient can be seen with migraine or more rarely with a colloid cyst of the third ventricle. When a nonpainful stimulus can induce pain over the scalp region, it is termed cutaneous allodynia and is seen in many migraine patients and some cluster headache patients. The manifestations of allodynia are listed in .
Table 2 Cutaneous allodynia: The manifestations
Ask for associated neurological complaints such as seizures, syncope, double vision, etc. Ask about behavior during the attack. Irritability and confusion with the headache should suggest migraine and restlessness or pacing up and down is more with cluster headache. Ask for disability or limitation of activities during the headache, which usually happens with migraine. The extent of disability can be gauged using instruments[7
] such as MIDAS or HIT-6. The items on these Instruments of Disability Assessment are featured in .
Ask for any visual or sensory aura?
Ask for auras that may preceed or accompany the head pain of migraine. Visual auras are the most common. Auras occur in succession, and the same patient may have a visual aura, followed sequentially by sensory paresthesiae or speech difficulty. Conditions that can mimic a migraine aura include strokes, TIAs, seizure disorders, tumors, venous thrombosis, arteriovenous malformations and carotid dissections. The onset, progression and duration of the symptoms help to differentiate between a migraine aura and a TIA or a seizure. Difficulty in making a distinction between these entities occurs when the aura is not followed by a headache. A gradual onset and progression over a few minutes is characteristic of a migraine aura as compared with a sudden onset in a TIA or a seizure. The classical duration of a migraine aura is 20–30 minutes as compared with a significantly shorter duration for a seizure and a longer one for a TIA.
Ask if there is just one type or more than one type of headache?
This implies distinctive types of headache and not headache of different levels of severity. Migraine and cluster headache can coexist, cluster headache can be associated with trigeminal neuralgia (cluster–tic syndrome) or migraine patients may have acute sinusitis. Two types of headache can coexist and need to be treated separately. Therefore, it is important to recognize different headaches when they coexist. When there is more than one type of headache, it helps to have the details of each type of headache.
Ask if the headache is precipitated or significantly worsened by the Valsalva manouvre’? Ask if there is worsening with sexual intercourse? Ask if there is postural worsening?
Worsening with Valsalva manoeuvre or with coughing or laughing or sneezing suggests a need to rule out a posterior fossa or cranio-verteberal junctional anomaly such as a Chiari I malformation. If a secondary cause is ruled out, then one can diagnose a primary cough headache. When a headache worsens on exertion, one must keep in mind the possibility of cardiac cephalalgia, phaeochromocytoma, dissection or primary exertional headache. If a headache begins or worsens with sexual activity, suspect a sub-arachnoid hemorrhage or dissection or primary sexual headache. There are some headaches such as those due to spontaneous intracranial hypotension or postlumbar puncture that can worsen with change to the erect posture. Headaches due to raised intracranial pressure can worsen in the supine position. Ask for aggravation of the headache with physical activity as in migraine.
Ask about the personal history, habits and occupation?
Ask for details of personal habits that may worsen headaches. Consumption of alcohol can aggravate cluster headache during the active phase. Ask about excess caffeine consumption, such as with too much coffee or tea or caffeinated beverages. Ask about sleep pattern and sleep disturbances.
Ask for a family history of headaches?
Asking about a history of similar headaches in other family members may elicit “No” for an answer. Asking about “any” headache at all will tell you about the presence of headaches in other members of the family.
Ask about the impact of the headache on the patient's lifestyle?
This will tell you how disabling the headaches are and this will also help build a rapport. There are instruments such as MIDAS and HIT 6, but these will need monitoring of the headache using a headache diary.
Ask about medication overuse?
It is well established that overuse of/self-medication with analgesics containing caffeine and codeine, combination analgesics, ergotamine or triptans can result in chronic headache.[8
] Always remember to ask about the specific acute headache medication consumed, the number of tablets and number of days for which they have taken it. Some medications taken for other conditions can have headache as a side-effect, for e.g. the combined oral contraceptive or phosphodiesterase inhibitors can worsen migraine headache. Coronary vasodilators can be associated with severe headaches. A careful drug history is important. Many cardiovascular dilatory drugs such as the nitrates, antiarrhythmics, some of the agents for erectile dysfunction can cause headache as a side-effect.
Ask about the interictal status?
This will tell you the interictal state of health. It is important to know if there is a background headache or if the headache comes in recurrent attacks that are trigger-linked.
Ask about investigations that have been done so far? And the treatment that has been taken so far?
While taking the history, one has to also plan for investigations based on the differential diagnosis and the tests that have already been done. If a patient tells you that he has had a recent scan done that is normal, it will reassure you and also tell you that you are dealing with a primary headache. Asking about the previous treatments will tell you about failed treatments and will help you plan the further line of treatment.
Ask if there is anything else that the patient wants to tell you? Ask if there are any other complaints or medical problems?
This query will bring out other medical illness that may be related or unrelated, for e.g. asthma, polycystic ovarian syndrome, hypothyroidism, hyperprolactinemia, previous head or neck trauma, drug allergies, history of hypertension and history of medications for other conditions. Some headache medications may be contraindicated with other medical conditions, e.g. betablockers in bronchial asthma. Ask for history of fever and weight loss, which should indicate a systemic infection or malignancy. A history of galactorrhea in a headache patient will warrant ruling out of a hyperprolactinemia secondary to a pituitary adenoma. Malarial fevers or viral fevers can sometimes be followed by intense headache. Ask the right questions to rule out immunocompromised states like HIV that can lead to opportunistic infections. Rarely, neurosarcoidosis or Lyme disease can present with headache. Ask to check if there is an occupational history that can aggravate headaches.
Specific settings needing additional history
Beyond the standard history, headache history-taking should NOT follow the same set pattern in all patients. You need to adapt and modify based on the setting and the suspected diagnosis. If the patient presents to the Emergency Department with a sudden onset headache, you may need to take a quick history and you may sometimes need to order tests. You may sometimes need to start treatment even before you diagnose. History taking in an emergency department is therefore different from history taking in an office setting; history in a child with headache will differ from the elderly patient beyond 50 years who presents with headache, where different causes will need to be suspected.
It will be beyond the scope of this review to discuss each condition that can present with headache, but the conditions to be considered in different settings are grouped in a tabular form, and this should help you ask the right questions in the right setting.
Thunderclap headache (TCH) refers to a sudden, severe headache that attains peak intensity at onset itself. TCH is defined in ICHD-21
as a severe headache reaching maximal intensity within seconds to a minute. The rapidity of onset and the severity are the characteristic features of TCH. The conditions that can present with TCH range from benign to life-threatening, and are listed in .[9
Table 4 Causes of thunderclap headache Chronic daily headache
Chronic daily headache or CDH is the umbrella term used to describe patients who present with headache on more than 15 days/month for more than 3 months. CDH is divided into two groups: Primary and secondary CDH. Secondary causes of CDH should always be ruled out before diagnosing primary CDH. The causes of CDH have been listed in .
Table 5 Chronic daily headache (CDH): The causes
The number of headache days, the duration of the headache, the number of days on which the headache fulfills the criteria for migraine, the response to ergots or triptans and the presence of medication overuse have all to be enquired about in order to make the diagnosis of chronic migraine.[10
New onset headache
When there has been no history of headaches in the past and the headache occurs on a daily basis for more than 3 months, it would be labeled as NDPH[11
] or New Daily Persistent Headache, but only after making sure that other secondary conditions have been ruled out. The causes that need to be ruled out before diagnosing NDPH will be covered in a separate article.
Indomethacin responsive headaches
Because there are some conditions that respond exquisitely to Indometacin, you need to be able to suspect and identify these headaches. CPH and Hemicrania Continua are exquisitely responsive to Indomethacin. Some of the other conditions that are responsive to Indomethacin are Valsalva-induced headaches, primary cough headache and primary stabbing headache.
Headaches originating in overlap specialities
There are many causes of headaches in areas with overlapping nerve supply and which are often in the realm of overlapping specialties such as Oto-rhinolaryngology and Ophthalmology. These headaches need to be referred to the right specialists. When you suspect a sinus infection, ask for history of purulent discharge, fever and tenderness over the sinuses. Ophthalmic conditions can be present with headache. Subacute angle closure glaucoma is often deceptive and one has to suspect the entity in the right setting and be alert on examination and refer appropriately. Some important Otorhinolaryngologic and Ophthalmic causes of headache are listed in .
Table 6 Otorhinolaryngologic and ophthalmic causes of headache Headache in children
There are some headache conditions such as abdominal migraine and cyclic vomiting syndrome that are seen more often in children. Always ask for history of recurrent abdominal pain and recurrent intractable attacks of severe vomiting. Migraine headaches in children are of shorter duration, bifrontal in location, may not have all the accompaniments as seen in adults and are characteristically relieved by sleep. Ask about food habits in children – excessive chocolates, cheese, caffeinated drinks and monosodium glutamate containing fast food items are well known to worsen headaches. Even very young children can present with migraine.
Headaches in the elderly
There are also some conditions seen that you need to suspect in the elderly and ask the right questions. Comorbid conditions and medication for other illnesses can cause headaches in the elderly. Secondary headache disorders such as giant cell arteritis, neoplasms, metabolic abnormalities and glaucoma are some conditions to be considered in the elderly.
Specific entities needing additional history
ICHD2 (2004) has specific criteria that need to be fulfilled for the different headache conditions. It is worthwhile remembering the criteria for the common primary headache conditions that one comes across in practice, viz. migraine, cluster headache and tension-type headache. These common conditions and the additional questions that one must ask are discussed below.
The diagnosis of migraine needs recognition of the pattern of recurrent trigger-linked episodes of headache with accompaniments such as nausea, vomiting, photophobia and phonophobia. Migraine attacks usually follow a sequence of a prodrome, aura, headache and postdrome. Ask the right questions to establish the sequence or to make a phasic diagnosis of migraine. The premonitory symptoms of difficulty in concentration, feeling low and tired, neck pain, yawning, food cravings and other hypothalamic disturbances can sometimes give a clue to the diagnosis of migraine. You therefore have to ask questions to elicit and establish these characteristic features. There may or may not be a visual or sensory aura. When you suspect migraine with aura, you have to ask additional questions about the aura – the type of aura, the duration, the sequence. If an aura is present, you have to always differentiate between a seizure disorder and a transient ischemic episode. A useful question to ask in order not to miss migraine with aura would be, “Do you have a visual defect or any other neurological problem before or along with the headache? Ask about the prodrome after the headache. Ask if the patient feels tired or drained or fatigued.
There are many features in migraine patients that are not covered by the IHS criteria.[12
] Migraine headache is not always unilateral, not always throbbing and can present without nausea, vomiting, photophobia or phonophobia when it is called “Probable Migraine”. You should therefore not be surprised to see migraine presenting in an atypical incomplete manner that is not always described in textbooks.
In women, migraine more often starts at menarche, can worsen around the periods, in pregnancy, with contraceptive use, with use of hormones to treat infertility or polycystic ovarian disease and around menopause with hormone replacement therapy. Migraine decreases during the second and third trimester of pregnancy. There may be a positive family history. Migraine can less commonly present with onset at a later age when you have to make sure that you are not dealing with a late-life migraine accompaniment or a secondary headache.
Always ask about accompanying autonomic signs and symptoms in headache patients. Head pain associated with lacrimation, nasal stuffiness, conjunctival injection, facial swelling or Horner's syndrome on the same side as the head pain should alert you to the possibility of cluster headache or one of the TACs. The duration of the attacks in TACs is shorter than in migraine, they are more frequent, you can get more than one attack per day and they are generally side-locked. The TACs will be discussed in detail in another article. In all patients with migraine or cluster headache, ask for overlapping features. Cluster headache patients can present with aura, photophobia, phonophobia, nausea or vomiting and migraine patients can have associated autonomic features. With intractable TACs, ask to rule out obstructive sleep apnea and look for atypical patterns that should raise suspicions of an underlying secondary cause.
Tension-type headaches are “featureless headaches” without accompaniments and are not so common in headache patients who decide to consult. They are more common in the general population than in patients seen in the clinic.