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Published online Sep 12, 2012. doi: 10.1371/journal.pone.0045006
Table 3
The effect of L-carnosine on the viability of yeast strains with deletions in the TOR, Sch9 and PKA nutrient sensing pathways.
Viability (%)
Strainno L-carnosine+10 mM L-carnosine
Wild-type99.33 (0.33)84.85 (1.89)
tor1Δ99.87 (0.20)94.20 (1.30)
rpl31Δ100 (0.00)99.33 (0.67)
gpa2Δ100 (0.00)97.99 (0.22)
tpk1Δ100 (0.00)91.67 (2.25)
gpr1Δ100 (0.00)97.42 (1.21)
sch9Δ100 (0.00)96.44 (0.33)
hxk2Δ100 (0.00)98.22 (1.07)
Yeast cells were grown in shake-flasks at 30°C in YP medium supplemented with 2% glucose, with or without 10 mM L-carnosine. Viability (%; determined by trypan blue dye exclusion) was determined in triplicate. The standard error of the mean (SEM) is given in parentheses.
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