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Published online 2012 September 12. doi: 10.1371/journal.pone.0045006

Figure 2

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L-Carnosine addition profoundly affects the metabolism of yeast cells grown on the fermentable carbon source, 2% glucose.

Yeast cells were cultured in shake-flasks at 30°C in 2×CBS medium supplemented with 2% glucose in the presence of 0–30 mM L-carnosine, as indicated, and the heat output rate measured by on-line flow microcalorimetry. Control cells exhibit a classic biphasic metabolic profile on glucose; on addition of L-carnosine the profile is altered and the delayed onset of a single, broad peak is observed.

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