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Autoimmune Dis. 2012; 2012: 301274.
Published online Sep 2, 2012. doi:  10.1155/2012/301274
PMCID: PMC3437607
Neonatal Lupus Erythematosus
Kam Lun Hon 1 * and Alexander K. C. Leung 2
1Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, 6/F, Clinical Sciences Building, Shatin, Hong Kong
2Department of Pediatrics, Alberta Children's Hospital, The University of Calgary, Calgary, AB, Canada T2N 1N4
*Kam Lun Hon: ehon/at/
Academic Editor: Hiroshi Okamoto
Received June 4, 2012; Revised July 29, 2012; Accepted August 2, 2012.
Neonatal lupus erythematosus (NLE) refers to a clinical spectrum of cutaneous, cardiac, and systemic abnormalities observed in newborn infants whose mothers have autoantibodies against Ro/SSA and La/SSB. The condition is rare and usually benign and self-limited but sometimes may be associated with serious sequelae. We review the pathophysiology, clinical features, and management of infants with this condition. Neonates with NLE should be managed at a tertiary care center. Multidisciplinary team involvement may also be indicated. In mothers with anti-Ro/SSA and/or anti-La/SSB antibodies and infants with congenital heart block, the risk of recurrence in subsequent offspring is 17–25%. Therefore, careful monitoring of subsequent pregnancies with serial ultrasonography and echocardiography is essential.
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