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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
 
From:
Angew Chem Int Ed Engl. Author manuscript; available in PMC 2013 July 9.
Published in final edited form as:
Angew Chem Int Ed Engl. 2012 July 9; 51(28): 6908–6911.
Published online 2012 June 11. doi: 10.1002/anie.201201690

Table 1

Thermodynamic parameters of MO/RNA duplexes

MO oligomer[a]Tm (°C) linear[b]ΔG (kcal/mol) linear[b]Tm (°C) cyclic [b]ΔG (kcal/mol)cyclic[b]ΔTm (°C)[c]ΔΔG (kcal/mol)[c]
25-base78.3 ± 0.9−22.1 ± 2.375.2 ± 1.2−18.5 ± 0.73.1 ± 0.73.6 ± 0.9
23-base77.0 ± 2.0−20.4 ± 2.068.7 ± 1.3−15.9 ± 1.08.3 ± 0.94.5 ± 0.9
21-base74.2 ± 1.3−19.7 ± 1.160.2 ± 1.3−14.0 ± 0.414.0 ± 1.15.7 ± 0.7
[a]See Table S1 for sequence information.
[b]Average values of 3–12 experiments ± s.d.
[c]Absolute differences between linear MO/RNA and cyclic MO/RNA duplexes ± s.e.