Even with the rarity of ATC, many prognostic factors have been reported. Reporting their clinical experiences in a single institution, Venkatesh et al. [1] found that young age at initial diagnosis and locally confined disease were associated with better prognosis. A review article found that better prognosis was associated with female sex, lesion size <6 cm, patient age <60 years, less extensive disease, and no distant metastases at initial presentation [10]. Multidisciplinary treatment and presence of intrathyroidal disease were also associated with better prognosis [7,13]. Because of the rarity of the disease, the treatment modalities applied in these reports were varied. Thyroid malignancy is typically detected by health screening; thus, in the future, increased early detection of ATC cases is expected.

Data processing and statistical analyses were performed by a statistician with the SPSS ver. 19.0 (SPSS Inc., Chicago, IL, USA). To evaluate clinicopathologic characteristics between patients surviving <6 months and ≥6 months, Fisher's exact test was used for the analysis of categorical data (such as lymph node metastasis) and Mann-Whitney U test was used for continuous variables. A P-value of <0.05 was considered statistically significant.

Treatment modalities for ATC include combination therapy with surgical resection for local control, external beam radiotherapy, and chemotherapy. The combination of surgery and radiotherapy is the most effective treatment modality in controlling local disease [16]. Radical resection of ATC is considered to be an important therapy in locally advanced disease [17]. One published report, based on a 30-year single-center experience, found that maximal debulking surgery combined with adjuvant chemotherapy was the best method in patients with ATC [18], while another study indicated that tumor debulking should be performed before adjuvant therapy. They reported a single center experience of eight patients who underwent potentially curative surgery, and estimated the 2- and 5-year survival rates as 75% and 50%, respectively [19]. The role of surgery as a treatment modality has been unclear; nevertheless, surgery should be considered in the treatment of ATC, especially when treating its relatively less aggressive forms. Multimodal treatment including surgery is ideal for prolonged locoregional control and patient survival [20].

Although many studies have been performed with various treatment approaches, the survival benefits of these modalities remain unclear [21]. Reported prognostic factors include patient age, tumor size, extent of disease, and treatment modality. However, these factors have been found under heterogeneous combinations of treatment modalities or palliative therapy. Two published reports have concerned Korean patients diagnosed with ATC. Chang et al. [6] reported difficulties in the treatment of ATC due to its poor prognosis. Kim et al. [22] stated that curative surgery and adjuvant radiotherapy should be applied in selected patients with tumor size <5 cm, age <55 years, and no distant metastasis at initial presentation. However, these previous studies included some palliative cases that underwent debulking or incomplete surgery (e.g., biopsy only).

We assessed the usefulness of surgery in patients who were expected to undergo curative surgery preoperatively. Analysis of 12 patients indicated that surgery should be actively considered when the tumor size is <5 cm and there is no evidence of distant metastasis on preoperative work up. Even with the small sample size, the median operation time was appreciably shorter compared to that in patients with lesions of ≥5 cm. Moreover, all patients with lesions of <5 cm underwent total thyroidectomy. The findings indicate that, in patients with lesions of <5 cm in size, total thyroidectomy is a convenient and simple option for an experienced surgeon.

In this study, three of the seven patients who survived ≥6 months showed focal residual differentiated thyroid cancer cells by pathologic review. Although the proportion of focal differentiated thyroid cancer cells was very small, this finding may suggest a relationship between relatively good survival and ATC originated from differentiated thyroid cancer. However, two of three patients showing focal differentiated thyroid cancer cells survived <6 months from initial surgery, and only one patient survived ≥6 months. Therefore, it is difficult to say that relatively good survival has a relationship with ATC derived from differentiated thyroid cancer.

The median survival from initial surgery of the seven patients who survived ≥6 months was 2,782 days (range, 865 to 3,153 days). Statistical data related to mortality were obtained from the National Statistics Office, and the last end point for mortality statistics was 31 December 2010. Six of the seven patients underwent surgery between 2002 and 2007; one patient underwent surgery in 1997 and died in 1999. Therefore, in spite of the dismal prognosis of ATC, good survival can be expected in patients with ATC who undergo curative surgery.

Three of the five patients surviving ≥6 months and five of the seven patients surviving <6 months underwent postoperative adjuvant radiotherapy treatment at median dosages of 5,420 and 6,030 cGy, respectively. The effectiveness of radiotherapy for local disease control cannot be discussed within the context of this study. Further large-scale, multicenter studies will be required to assess this topic among patients expected to undergo curative surgery. Even we couldn't find the role of radiotherapy as an adjuvant treatment modality, the remaining is the fact that prolonged survival was achieved in small group of patients underwent curative resection.

For unknown reasons, the incidence of well-differentiated thyroid cancer is increasing [10,23], while the incidence of ATC has decreased. Several possible explanations are offered for the decreasing incidence [10], such as aggressive resection of well-differentiated thyroid malignancy, which eliminates the potential of dedifferentiation [24], and improved iodine prophylaxis and socioeconomic status [25]. This trend leads to the expectation that future cases of ATC cancer should be detected at earlier stages than in past decades. The present attempt to find prognostic factors in patients with ATC with expected curative thyroidectomy preoperatively can offer one clue for the treatment of ATC.

This study had some limitations. Firstly, the sample size was very small. However, the demographic results echo those of other published studies, making it more likely that these data from a single center are valid. Secondly, there was a possibility of selection bias, because the authors limited the cases to patients who underwent thyroidectomy. To overcome these limitations, because of the rarity of the disease, a multicenter approach utilizing strict inclusion criteria would be required.