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Logo of bmcsbBioMed Centralsearchsubmit a manuscriptregisterthis articleBMC Structural Biology
BMC Struct Biol. 2012; 12: 17.
Published online 2012 July 16. doi:  10.1186/1472-6807-12-17
PMCID: PMC3427135

Integrative structural modeling with small angle X-ray scattering profiles


Recent technological advances enabled high-throughput collection of Small Angle X-ray Scattering (SAXS) profiles of biological macromolecules. Thus, computational methods for integrating SAXS profiles into structural modeling are needed more than ever. Here, we review specifically the use of SAXS profiles for the structural modeling of proteins, nucleic acids, and their complexes. First, the approaches for computing theoretical SAXS profiles from structures are presented. Second, computational methods for predicting protein structures, dynamics of proteins in solution, and assembly structures are covered. Third, we discuss the use of SAXS profiles in integrative structure modeling approaches that depend simultaneously on several data types.

Keywords: Small Angle X-ray Scattering (SAXS), Protein structure prediction, Macromolecular assembly, Integrative modeling

Articles from BMC Structural Biology are provided here courtesy of BioMed Central