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From:
Published online 2012 August 8. doi: 10.1186/1741-7015-10-86

Table 4

Overview of selected studies on carbohydrate antigen 125 levels during normal pregnancy.

Author/year of publicationStudy designLaboratory techniqueNumber of patientsCut-off value
(U/mL)
Trimester 1 Trimester 2Trimester 3Conclusion
1Niloff 1984 [12]cross-sectional125I-labeled OC125N = 101<65>65 in 16%< 65<65T1: 16% above cut-off value
2Haga 1986 [13]cross-sectionalCentocore Inc., Malvern, PA, USAT1 n = 29; T2 n = 21; T3 n = 21<3585 ± 101
(mean ± SD)
18 to 550 (range)
20 ± 10
10 to 54
25 ± 27
<8 to 140
Raised above cut-off value, percentage not stated
3Jacobs 1988 [14]cross-sectionalAbbott Laboratories, Chicago, IL, USAT1 n = 11; T2 n = 7; T3 n = 8<3553.6 (median)
15.6 to 268.3 (range)
18.5
12.0 to 25.1
19.2
16.8 to 43.8
35% above cut-off value
4Kobayashi 1989 [15]both cross-sectional and longitudinalORIS Industry, Censaclay, Francen = 122<3571.7 ± 71.1
(mean ± SD)
19.1 ± 7.028.1 ±14.1Raised above cut-off value, percentage not stated
5Touitou 1989 [16]cross-sectionalIRMA, CIS-Bio International, Gif-Sur-Yvette, FranceT1 n = 32; T2 n = 32; T3 n= 36<3523.7± 13.9
(mean ± SD)
14.8 ± 8.022.1 ± 17.18% above cut-off value
6Kenemans 1992 [17]cross-sectionalEnzymun CA 125 (Boehringer, Mannheim, Germany)T1 n = 26; T2 n = 20; T3 n = 145<3524.4 ± 13.3
(mean ± SD)
54.6 (maximum range)
38.1 ± 47.4
166.6
74.7 ± 273.3
2,419.7
T1: 19% above cut-off value
T2: 15% above cut-off value
T3: 20% above cut-off value
7Schlageter 1998 [7]longitudinalELSA-CA 125 (CIS Bio International-Bio International, Gif-Sur-Yvette, Francen = 12<4018.7 ± 14.0
(mean ± SD)
6.1 to 41.5 (range)
19.9 ± 12.5
6.5 to 54.3
22.3 ± 13.1
6.1 to 51.3
Raised above cut-off value, percentage not stated
8Spitzer 1998 [18]longitudinalCentocore Inc., Diagnostic division, Malvern, PA, USAn = 20<3533.1 (median)
3.7 to 251.2
(range)
<35<35Raised above cut-off value, percentage not stated
9Bon 2001 [10]cross-sectionalEnzymun-Test CA 125 (Boehringer, Mannheim, Germany)T1 n = 127; T2 n = 192; T3 n = 47Not stated23 (median)
4 to 108 (range)
14
1 to 73
21
8 to 144
Raised above cut-off value, percentage not stated
10Ercan 2012 [11]longitudinalModular Analytics E 170 Module (Roche diagnostics, Basel, Switserlandn = 30<3519.0 (median)
4.9 to 61 (range)
15.6
4.7 to 32.1
19.6
9.8 to 41.2
4.4% above cut-off value

CA, carbohydrate antigen; ELISA, enzyme-linked immunosorbent assay; IRMA, immunoradiometric assay; SD: standard deviation; T, trimester;