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From:
Published online Aug 8, 2012. doi: 10.1186/1741-7015-10-86
Table 3
Overview of selected studies on carbohydrate antigen 15-3 levels during normal pregnancy.
Author/year of publicationStudy designLaboratory techniqueNumber of patientsCut-off valueTrimester 1 Trimester 2Trimester 3Conclusion
1Touitou 1989 [6]cross-sectionalIRMA, CIS-Bio International, Gif-Sur-Yvette, FranceT1 n = 32; T2 n = 32; T3 n = 36<2511.1 ± 4.2
mean ± SD
14.2 ± 5.117.0 ± 5.0None above cut-off value
2Schlageter 1998 [7]longitudinalELSA-CA 15-3 (CIS-Bio International), Gif-Sur-Yvette, Francen = 12<309.3 ± 4.0
(mean ± SD)
5 to 15 (range)
14.1 ± 4.1
10 to 22.8
16.5 ± 4.1
8.8 to 24.2
None above cut-off value
3Botsis 1999 [8]cross-sectionalEIA, Tumor markers CA 153, Abbott AXSYM system, Abbott Park, Il, USAT1 n = 20; T2 n = 29; T3 n = 26<3318.0 (median)
14 to 30 (range)
20
1.0 to 34
22
12 to 41
5%, 10% and 20% above cut-off value, in the 3 trimesters respectively
4Cheli 1999 [9]cross-sectionalBayer Immuno 1 CA 15-3 assay, Tarrytown, New York, USA)T1 n = 32; T2 n = 5; T3 n = 53<3516.76 (mean)-20.783.3% above cut-off value
5Bon 2001 [10]cross-sectionalEnzymun-Test CA 15-3 (Boehringer, Mannheim, Germany)T1 n = 127; T2 n = 192; T3 n = 47Not stated14.0 (median)
5.0 to 32 (range)
15.0
6.0 to 40
26.0
9 to 56
Raised above cut-off value, percentage not stated
6Ercan 2011 [11]longitudinalModular Analytics E 170 Module (Roche diagnostics), Basel, Switserland.n = 30<2517.5 (median)
7.6 to 39.3 (range)
19.7
10.4 to 39
18.3
7 to 38.6
16% above cut-off value
SD, standard deviation; T, trimester.
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