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Ann Thorac Med. 2012 Jul-Sep; 7(3): 171.
PMCID: PMC3425054

Serum hepcidin and chronic obstructive pulmonary disease


The recent report on serum hepcidin and COPD is very interesting.[1] Duru et al. concluded that “serum hepcidin level may be a useful marker in COPD.”[1] As Duru et al. proposed, a further confirmation is required. An important point is there is no complete assessment on hepatitis profile (such as hepatitis B, hepatitis C, etc.) needed. Also, some genetic disorders can also alter the hepcidin level that has to be ruled out. Thalassemia[2] as well as some other rare genetic mutations[3] should be ruled out. It is still very inconclusive to conclude for any usefulness of hepcidin as a new biomarker for COPD.


1. Duru S, Bilgin E, Ardiç S. Hepcidin: A useful marker in chronic obstructive pulmonary disease. Ann Thorac Med. 2012;7:31–5. [PMC free article] [PubMed]
2. Origa R, Galanello R. Pathophysiology of beta thalassaemia. Pediatr Endocrinol Rev. 2011;8(Suppl 2):263–70. [PubMed]
3. Melis MA, Cau M, Congiu R, Sole G, Barella S, Cao A, et al. A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron. Haematologica. 2008;93:1473–9. [PubMed]

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