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Bioinorg Chem Appl. 2012; 2012: 126451.
Published online Jul 31, 2012. doi:  10.1155/2012/126451
PMCID: PMC3415175
Binding Studies of a New Water-Soluble Iron(III) Schiff Base Complex to DNA Using Multispectroscopic Methods
Nahid Shahabadi,* Zeinab Ghasemian, and Saba Hadidi
Department of Inorganic Chemistry, Faculty of Chemistry, Razi University, Kermanshah 74155, Iran
*Nahid Shahabadi: nahidshahabadi/at/yahoo.com
Academic Editor: Giovanni Natile
Received April 4, 2012; Accepted June 11, 2012.
Abstract
A novel iron(III) complex [Fe(SF)](ClO4)3.2H2O; in which SF = N,N0-bis{5-[(triphenylphosphonium chloride)-methyl] salicylidene}-o-phenylenediamine) has been synthesized and characterized using different physicochemical methods. The binding of this complex with calf thymus (CT) DNA was investigated by circular dichroism, absorption studies, emission spectroscopy, voltammetric studies, and viscosity measurements. The results showed that this complex can bind to DNA via external and groove binding modes.
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