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Logo of bmrBone Marrow Research
Bone Marrow Res. 2012; 2012: 270425.
Published online 2012 July 30. doi:  10.1155/2012/270425
PMCID: PMC3413998

Hematopoietic Stem Cell Development, Niches, and Signaling Pathways


Hematopoietic stem cells (HSCs) play a key role in hematopoietic system that functions mainly in homeostasis and immune response. HSCs transplantation has been applied for the treatment of several diseases. However, HSCs persist in the small quantity within the body, mostly in the quiescent state. Understanding the basic knowledge of HSCs is useful for stem cell biology research and therapeutic medicine development. Thus, this paper emphasizes on HSC origin, source, development, the niche, and signaling pathways which support HSC maintenance and balance between self-renewal and proliferation which will be useful for the advancement of HSC expansion and transplantation in the future.

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