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Logo of annaldermaThis ArticleThis JournalAboutInformation for AuthorsOnline SubmissionAnnals of Dermatology
 
Ann Dermatol. 2012 August; 24(3): 341–344.
Published online 2012 July 25. doi:  10.5021/ad.2012.24.3.341
PMCID: PMC3412244

Successful Treatment of Alopecia Areata with Topical Calcipotriol

Dong Ha Kim, M.D., Jin Woong Lee, M.D., In Su Kim, M.D., Sun Young Choi, M.D., Yun Young Lim, Ph.D., Hyeong Mi Kim, M.S., Beom Joon Kim, M.D., Ph.D.,corresponding author and Myeung Nam Kim, M.D., Ph.D.

Abstract

Alopecia areata (AA) is an inflammatory hair loss of unknown etiology. AA is chronic and relapsing, and no effective cure or preventive treatment has been established. Vitamin D was recently reported to be important in cutaneous immune modulation as well as calcium regulation and bone metabolism. It is well known that areata is common clinical finding in patients with vitamin D deficiency, vitamin D-resistant rickets, or vitamin D receptor (VDR) mutation. The biological actions of vitamin D3 derivatives include regulation of epidermal cell proliferation and differentiation and modulation of cytokine production. These effects might explain the efficacy of vitamin D3 derivatives for treating AA. In this study, we report a 7-year-old boy with reduced VDR expression in AA, recovery of whom was observed by topical application of calcipotriol, a strong vitamin D analog.

Keywords: Alopecia areata, Calcipotriol, Therapeutics, Vitamin D

Articles from Annals of Dermatology are provided here courtesy of Korean Dermatological Association and Korean Society for Investigative Dermatology