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Logo of annaldermaThis ArticleThis JournalAboutInformation for AuthorsOnline SubmissionAnnals of Dermatology
Ann Dermatol. 2012 August; 24(3): 280–286.
Published online 2012 July 25. doi:  10.5021/ad.2012.24.3.280
PMCID: PMC3412236

An Open-Label, Split-Face Trial Evaluating Efficacy and Safty of Photopneumatic Therapy for the Treatment of Acne

Eun Ju Lee, M.D., Hee Kyeong Lim, M.D., Min Kyung Shin, M.D., Dong-Hye Suh, M.D.,1 Sang-Jun Lee, M.D.,1 and Nack In Kim, M.D.corresponding author



Acne vulgaris is the most common skin disease worldwide, with many available treatment modalities, including oral and topical medications and laser therapy. Recently, a novel device (Isolaz, Pleasanton, CA, USA) that combines vacuum pressure and a broadband light source (400 nm to 1,200 nm) was developed for the treatment of acne.


To determine the clinical efficacy and safety of photopneumatic therapy for the treatment of acne vulgaris of the face.


Twenty adults with mild to moderate facial acne vulgaris received 4 successive treatments on one side of the face with a combined photopneumatic device (intense pulsed light: fluence=5.8 J/cm2; negative pressure=iMP mode) at 2 week intervals. Acne lesions on the opposite side of the face were not treated. Lesion counts were performed at baseline, prior to each treatment session, and at 3 months after the final treatment session.


Significant lesion improvements and reduced numbers of acne lesions were observed on the treated side of the faces. Most patients experienced global clinical improvement. No severe side effects occurred during the study, with only a few patients experiencing transient erythema, purpura and/or exacerbation of pre-existing acne.


Photopneumatic therapy is a safe and effective treatment for mild to moderate acne vulgaris.

Keywords: Acne vulgaris, Intense pulsed light

Articles from Annals of Dermatology are provided here courtesy of Korean Dermatological Association and Korean Society for Investigative Dermatology