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Adv Orthop. 2012; 2012: 834208.
Published online Jul 26, 2012. doi:  10.1155/2012/834208
PMCID: PMC3412089
Recent Findings on the Role of Gelatinases (Matrix Metalloproteinase-2 and -9) in Osteoarthritis
Olimpio Galasso, * Filippo Familiari, Marco De Gori, and Giorgio Gasparini
Department of Orthopaedic and Trauma Surgery, School of Medicine, University Magna Græcia of Catanzaro, Europa Avenue, 88100 Catanzaro, Italy
*Olimpio Galasso: galasso/at/
Academic Editor: Zoe Dailiana
Received December 18, 2011; Accepted May 27, 2012.
Several studies dealing with the pathomechanisms of OA refer to MMP-1, -3, -7, -8, and -13 whereas a smaller number of investigations have pointed out the pathogenic role of gelatinases in OA. These gelatinases are best known for their involvement in pulmonary, myocardial, and neoplastic disease but they are emerging as important proteases implicated in the OA progression. This paper highlights the role of the gelatinases as emerging factors in OA pathogenesis through the regulation of subchondral bone resorption and microvascular invasion. The most significant new findings over the last year that add to our knowledge of the activity of these proteins in OA have been reported.
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